6H67


Conserved Protein Domain Family
RNA_pol_I_A49

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pfam06870: RNA_pol_I_A49 
A49-like RNA polymerase I associated factor
Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures. Deletion analysis of the fusion yeast homolog indicate that only the C-terminal two thirds are required for function. Transcript analysis has demonstrated that A49 is maximizing transcription of ribosomal DNA.
Statistics
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PSSM-Id: 462024
Aligned: 104 rows
Threshold Bit Score: 193.209
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6H67_M        33 PSDTTFDLYK------KKksEKDEFVLHGEN-ERLEYEGYTDSSSQASN----------------QYVVGLFNPEKKSIQ 89  Saccharomyces c...
EGT52755      43 LDKLVFERHGki---gPK--KAPIFTVNEAIsERVVEVGTEVNCIEDGF----------------DFVVAIVDNETGNAN 101
Q95X83        43 LKNLTFERHGkg---gRK--KAPIFSVKGDIsEHVVEVGADVNCLDEGF----------------DFAVALVDKRTGEAT 101 Caenorhabditis ...
1_pfamImport   1 LQNLKFERHGka---gRK--KAPIMSVKGEIcEKVMEIGTDVNCLDEGF----------------DFAVAVVDTETGEAT 59 
XP_424416     31 PDAVRFSLYRssevanPR--KRRRRILVSET-ERLSYVGNNFGSGAMKCns------------lcRYFLGVLNKDTGQME 95 
XP_005061362  87 PDSLRFTVYRsqdtahPR--KKHRRILVSET-ERLCYVGHNFGSEVMKCns------------lcRYFVGVLDKNSGQME 151
XP_007498064  32 SENVNFSLYKskdttnPR--KKFRRILAAET-DRLSYVGNNFGTGALKCnn------------lcRYFVGVLNKNSGQME 96 
XP_004048088  36 PGNMRFTLYEnkdstnPR--KRNQRILAAET-DRLSYVGNNFGTGALKCnt------------lcRHFVGILNKTSGQME 100
EGV92192      51 PGNMRFTLYNsndlvnPR--LKNQRILAAET-DRLSYVGNNFGTGALKCnt------------lcRHFVGILNKTSGKGE 115
ELK12997      36 PGNIRFTLYKsndstnPR--KRSQRILVSAA--------------VARCstlqalgdpltggcgrEHFVGILNKTSGQME 99 
6H67_M        90 LYKAPVLVSKVVS--------KSSKNLRGPKI--------KSkSDTRpsaLRNALGEAFGTKKAKKAIADLERNRIDsDK 153 Saccharomyces c...
EGT52755     102 YHPARLYSFESKCtedfekllNDRKSLADNFEadf---siGAeKWAE---KRRQLTSNFGSSKKIKMDVAAQRRTINqET 175
Q95X83       102 YRPARFYSFESKFsedi-ekifSDKKESSSEEyknd-fsiGAeKWAE---KRRQLTSNFGSSKKIKMDEAAQRRTINqET 176 Caenorhabditis ...
1_pfamImport  60 YRPARFYSFESKYaedlekliGTNKKDTKNAEdyaedfsiGSdKWAE---KRRQLTSNFGSSKKIKMDEAAQRRTINqET 136
XP_424416     96 VYNAEIFNMQPLL--------SDNVIPDDTRd-------yQNkSYRE---KVDLCIEAFGTSKQKRALNSRRMNAVGnDI 157
XP_005061362 152 VYNAEIFNMQPLL--------SDNPLPDDTKd-------yQTkSYRE---KMDLCIEAFGTSKQKRALSSRRMNAVGtDI 213
XP_007498064  97 IYDAELFNMQPVF--------SDDLKDSETTLg------nQTkSYRD---QVDFCIEAFGTTKQKRALSSRRMNKVGsET 159
XP_004048088 101 VYDAELFNMQPLF--------SDVSVESELALe------sQTkTYRE---KMDSCIEAFGTTKQKRALNTRRMNRVGnES 163
EGV92192     116 VYDAELFNMQPLF--------AEDAIEQEPPPe------nQAkTFRE---KLDSCIEAFGSTKQKRSLNSRRMNKVGsES 178
ELK12997     100 VYDAELFNMQPLF--------SDDSVESESSLe------sQVkTFRE---KMDSCIEAFGTTKQKRALNSRRMNKVGsES 162
6H67_M       154 LTDSAIDIVDSVRTASKDlpt-------raQLDEITS-NDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEA 225 Saccharomyces c...
EGT52755     176 LDEMRKTAFASKSNIKKEdheefk-leditMMNKAAS---SILPPA-VQTELSRDIYPISLFLEELEIDAIESIATELMD 250
Q95X83       177 LDEMRKTAFASNSNVKTEdgaadvklenitMMNKAES---SILPPA-VQTELSRDIYPISLFLEDIEIDAIESIATELME 252 Caenorhabditis ...
1_pfamImport 137 LDEMRKTAFASNSNVKTEeqgdvk-lenitMMNKATS---SILPAA-VQTELSRDIYPISLFLEDVEVEAVKSLAEEVME 211
XP_424416    158 VSTAVTKAAADVIDAKGVtaliq--dvaqdDEQNMS----IFLPPCHEDADKPENVYKFEDILSPAEYEALQGPAAAFMN 231
XP_005061362 214 VSTAVTKAAANVIDAKGVtalvq--dvaqdDVQNIS----AFLPPCHEDADSPEHVYKFEDILSPAEYEALRVPAAALAS 287
XP_007498064 160 LNIAVAKAAENIIDEKGVtal------lndAAQNDLQdESAYLPPCHTDGVKPEEIYKFEDLISPEEYKALQDPSEVLKN 233
XP_004048088 164 LNRAVAKAAETIIDTKGVtal------vsdAIHNDLQdDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRN 237
EGV92192     179 LNLTVTKAAENIIDTKGVnalvs--damqdDLQDDS----LYLPPCHADATKPEDVYRFEDILSQAEYDALESPSEAFRK 252
ELK12997     163 LNHAVAKAAENIIDTKGVtalvs--daihdDLQDDS----LFLPPCHADAAKPEDVYEFEDLLSSAEYEALQSPSEAFRN 236
6H67_M       226 -DKEKKLelfpyqNNSKYVAKKLDSLTQPSQ-----MTKLQLLYYLSLLLGVYENRR-VNN---KtkllerlNSPPEILV 295 Saccharomyces c...
EGT52755     251 kKKKEKIe--------aGIPECVVLIMHNEKtkeraAAYLLLATMIEILMKMGKHRQmFLKem-------ndMKMPDILR 315
Q95X83       253 kKKKEKLe--------aGIPECVTLIMYNEKtkqraAAYLLLSTMIEILTKMGKQRQlLRKdl-------seLKMPDILR 317 Caenorhabditis ...
1_pfamImport 212 kKKKQRVe--------dGVPECVALIMYNEKveqraVAYLLLATMVEILAKMGRTRQvLRKel-------neLKMPDVLR 276
XP_424416    232 iTPEEIAkkteekSHCSFVLEELKFLPA--Dek-srDRKARCLWFLDILIKFSFLKIiKKKhp-------mgPECPHIIS 301
XP_005061362 288 iTTEELAkkaeerSHCSFVLEELKFLPT--Dek-srDHKARCLWFLDTLIKFSRLKViKKKhp-------mgPECPHIIS 357
XP_007498064 234 vTSEEILkmieekSYCPFVIEALKSLPLNEEs---rDHKARCLWFLNILIKFRSQSViKKKnslG-------PEVPHIIN 303
XP_004048088 238 vTSEEILkmieenSHCTFVIEALKSLPSDVEs---rDRQARCIWFLDTLIKFRAHRVvKRKsa-------lgPGVPHIIN 307
EGV92192     253 vTSEDILkmieenRHCSFVIEMLKSLPS--Nee-srDRQARSIWFLDALIRFRAQKViKGKsa-------lgPGIPHIIN 322
ELK12997     237 vTSEEILkmieenSHCSFVIEALKSLPS--Nee-srDHQARCIWFLDTLIRFRAQKViKRKsa-------lgPGVPHIIN 306
6H67_M       296 DGILSRFTVIKPgqfgrs--kdrsyfIDPQNEDKILCYILAIIMHLDNFI-VEITPLAHELNLKPSKVVSLFRVLGAIVK 372 Saccharomyces c...
EGT52755     316 QKVHAQFFNDTTsekgysgrsaerirLNVTDYDRLVAHTLALALTLAPEHkVPLTPFQQALAYQPSKLEKLFQALGADLI 395
Q95X83       318 QKVQAQFFNDSTnekgytgrgaerirLNVTDYDRFIAHTLALALTLAPEHkVPITPFQQALSYQPSKLEKMFQALGADLI 397 Caenorhabditis ...
1_pfamImport 277 QKVLAQFFNESIseknyagrgaervrLNVTDYDRFVAHTLALALTLAPEHkVPITPFQQAFGYQPSKLEKMFQALGADLI 356
XP_424416    302 RKLMKNFTSLTYnngs------vqnlISASLKTKIAAYVIALALHIKNFQ-TDLTVLQNDLKLHESRMMDIARAMRLKVS 374
XP_005061362 358 RKLMKNFSSLTYndgs------iqnlISASMKAKITAYVIALALHINNFQ-TDLTVLQNDMKLSETRILDIAKALRLRVS 430
XP_007498064 304 TKLLKNFTSLTYnngs------lrnlISDSMKAKITAYVIALALHIDDFQ-TDLTMLQRDMKLSEKRIIEIAKAMRLKIS 376
XP_004048088 308 TKLLKHFTCLTYnngr------lrnlISDSMKAKITAYVIILALHIHDFQ-IDLTVLQRDLKLSEKRMMEIAKAMRLKIS 380
EGV92192     323 TKLLKNFTCLTYnngs------lrnlISSSMKAKITAFAIILALHINSFQ-IDLTLLQGDLKLSEKRMIEIAKAMRLKIS 395
ELK12997     307 TKLLKHFTCLTYnngs------lrniISNSMKAKITAYVIILALHINDFQ-IDLTVLQRDLKLSEKRMIEIAKAMRLKIS 379
6H67_M       373 GATVAQAEAFGIpkstaaSYKI---ATMKVPFKLP 404 Saccharomyces cerevisiae S288C
EGT52755     396 RLDIASAQNL----------RSlraAILLKP---P 417
Q95X83       398 RLDVASAQTL----------RSlraAILLKP---P 419 Caenorhabditis elegans
1_pfamImport 357 RLDVQSAQNL----------RSlraAILLKP---P 378
XP_424416    375 KAKGMPGLENDQ------NHKL---GTLSLPLPVQ 400
XP_005061362 431 KAKGGPGLEDEH------NHKL---GTLSLPLPSQ 456
XP_007498064 377 KKKLSLESGGEE------HHKI---GTLSIPLPAL 402
XP_004048088 381 KRRVSVAAGSEE------DHKL---GTLSLPLPPA 406
EGV92192     396 KRKVTLADGREE------DHRL---GTLSVPLPPP 421
ELK12997     380 KRSVSLAAGTEE------EHKL---GTLCIPLPPA 405
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