Conserved Protein Domain Family
CYP6-like
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cd11056: CYP6-like 
cytochrome P450 family 6 and similar cytochrome P450s
This family is composed of cytochrome P450s from insects and crustaceans, including the CYP6, CYP9 and CYP310 subfamilies, which are involved in the metabolism of insect hormones and xenobiotic detoxification. The CYP6-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410679
Aligned: 82 rows
Threshold Bit Score: 337.204
Created: 17-Sep-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        #   #      # 
Q27593     69 SKAPFVGFFff-qsPAAFVIDLELAKQILIKDFSn-fSNKGIFynekddpi-----sahlfnldGAQWRLLRNKLSSTFT 141 fruit fly
Q9V776     74 GSGPFCGFYal-lqPRALILDRELIRQIMIKDFWn-fNDRGLYcnqksdpl-----sgdlyalrGESWKEMRQKLDPSLE 146 fruit fly
AAK32957   63 GKHPFGGIFqf-tePVAMITDPEMIRNVLVRDFRh-fYDRGGYinrqhdpl-----sghmlnsgSERWSVLRHASSPIFS 135 African malaria mo...
Q9V979     69 GRAPFVGFYac-lkPFILALDLKLVHQIIFTDAGh-fTSRGLYsnpsgepl-----shnllqldGHKWRSLHAKSAEVFT 141 fruit fly
Q9VWR2     63 PGLKYVGFYrlfnePAILVRDQELLRQILVGRNFadcADNAVYvdhqrdvla----shnpfianGDRWRVLRADLVPLFT 138 fruit fly
EAT40838   64 PTAAWVGIYelfnkPAIVVRDLELVKEILVGSFQh--FNRNSFevdetidpl---vainpftqsGDLWKERRSQVVPVFS 138 yellow fever mosquito
ABZ81072   68 HTGDYVGIFlg-fkPTLMVQTPEIARRILVKDNAh-fNNRYCYssygvdplg----slnlftvkNPKWSNIRHELSPMFT 141 domestic silkworm
EDS44706   66 GLNPLVGMYhy-lrPIALITDLGFVKRILEVDFEc-fQGRGSYcdekvdsl-----sgrlynlvGDRWNKIHNIIAPMFG 138 southern house mos...
EDW11134   70 GKERAVGVFlt-rqPQILVLDPQLAHEILVTNFSd-fRDTVTSsyvthskdydkyvsrnpffsaGDEWKKHRVDAGAGLT 147 Drosophila mojavensis
Q9VJ71     62 GKDRLLGIYcf-frPVLLVRNVELAQTILQQSNG---HFSELKwdy----------------isGYRRFNLLEKLAPMFG 121 fruit fly

Feature 1                                                    #                                
Q27593    142 SgkmklMYPTVVSVANEFMTVMHekvpkns--vleirdLVARFTVDVIGTCAFGiqc----------nsLRDEKAEFLYF 209 fruit fly
Q9V776    147 GdrmslLYDCLYEEAEQLLLTVNstlmsqphstvhiqkIMRRYVLSSLAKCVFGlna---------eqrKTYPLEDFEQM 217 fruit fly
AAK32957  136 TgrlraFLPEMVQMIDQFQAYLDaklaaeg-emielkgVLERHNTDIAMRFLLGreg----------nnLLAPEGGLHEA 204 African malaria mo...
Q9V979    142 PanmqkLLVRLSQISSRIQRDLGekslqt----iniseLVGAYNTDVMASMAFGl--------------VGQDNVEFAKW 203 fruit fly
Q9VWR2    139 PsrvrqTLPHVARACQLLRDQVPlgrf-------eakdLATRYTLQVVASAIFGlda----------hcLGIHMRVAHEP 201 fruit fly
EAT40838  139 QtkirsCFPIIKNVADNFLEYVTktrktsp--dfeakdICARFTIDSVASCAFGida----------esFTNPNSEFRRV 206 yellow fever mosquito
ABZ81072  142 SlrlktICELMNVNAKELVLKIQrdyidnn-edvnlkeLFSMYTSDTVGYTVFGlrv----------saLNDPSSPLWFI 210 domestic silkworm
EDS44706  139 GnnlktMFSMLLTSGKHLRDQLGdkveagk--eieiknWLKQYIPDLMAKSYLGvd-----------iqLKTISRQEKFK 205 southern house mos...
EDW11134  148 PnklkqAYAIWEQTGEQLVSFIQscieergsniietrdLCYRYTAQAMGDFIWGidagsltgsaketssFQRISTEWVTH 227 Drosophila mojavensis
Q9VJ71    122 TkrlseMFGQVQKVGDHLIHHLLdrqgqgcpqevdiqqKLRVYSVNIIANLIYGl-------------dINNFEHEDHIL 188 fruit fly

Feature 1                                                                                     
Q27593    210 GKRSLVDKRHgtllngfmrs--ypklarklgmVRTAPHIQEFYSRIVTETVAvre----kehIKRNDFMDMLIELKnqke 283 fruit fly
Q9V776    218 TELALNSHKHgylmnlmmir--fpnfcrmlrmRRTPKQAEEYFIKLLTSIVEqre----tsgKPQKDYLQLLIDVKalef 291 fruit fly
AAK32957  205 VMRGGFLLPSvwklflmtsy---rsvarklrlKVCSRELTETVERVAAEAINsklhehrpeaSRRVDLIDQLLKAPgfdg 281 African malaria mo...
Q9V979    204 TRNYWADFRMwqaylalef----pliarllqyKSYAEPATAYFQKVALSQLQlh-------rRRDRQPLQTFLQLYsnae 272 fruit fly
Q9VWR2    202 SRWLEWLAPLfqpsvwslletmsllhtprlgrLIGHRYVPLPLQHWFRELVEa--------rSGGDNLLQWLAESKrg-- 271 fruit fly
EAT40838  207 GFELFNPSSImatvrsllalf-apklasllriPFVPSYVDRWFRKLVNEVIRqrk----egeVKRQDLFQAMYDTLtqqg 281 yellow fever mosquito
ABZ81072  211 TNHMVKWDFWrgfeftaiff--vpalarflrlKFFSQPATEYIMRLFRTVVDerkk---tnqNTDKDLVNHLLKLKenlk 285 domestic silkworm
EDS44706  206 GFLMNYMSKLari----------------lriSEFKPEVSKHFLKLISAETEsrs----knnIRKDDFLDMLIQQLdpne 265 southern house mos...
EDW11134  228 AFLGMTRLNRttiapiv---------rrlfrmRFFTQAADDFYLKLTRDAAKlrqs---gsgGERSDYLAHLLQLQekg- 294 Drosophila mojavensis
Q9VJ71    189 TSYLSHSQASiqsf--------------tlgrLPQKSSYTYRLRDLIKQSVElre----dhgLIRKDILQLLVRFRngne 250 fruit fly

Feature 1                                 ##  ##  ##  #                                       
Q27593    284 mtlen------gdvvrgltMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVeevie-qhdqnFTYECT 356 fruit fly
Q9V776    292 ityqye----adkelgahlQNELAAHADVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVkkaie-rhdghITHEGI 366 fruit fly
AAK32957  282 ---------------ksslTLSEIAAQVFLFVAAYETNAITTFYCLYELAQRPELQQRARACVceale--khggITYEAI 344 African malaria mo...
Q9V979    273 ---------------kpltDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEInkale-ehggqVTPECL 336 fruit fly
Q9VWR2    272 -----------------lgKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELdevaqrhagnlIDPVAL 334 fruit fly
EAT40838  282 t--------------vdvkNDEIVGHSVTFLTEGFETSSTLMCYFLYELASNQHIQDRVLNEIdcvlk-eydgkLTDEAV 346 yellow fever mosquito
ABZ81072  286 lg-----------adiklaDEIMMAQAAVFILGSIETSSSTLSYCLHELAYHPEEQQKLFEEVddaiketgkeiLDYENL 354 domestic silkworm
EDS44706  266 sk------------egqlsFNELAAQAFGFYYAGLETCPALLTWTLYELSNAQVMQKKARQHVktala-kfngeICFDSI 332 southern house mos...
EDW11134  295 -----------------asLDDMVGHALTVLMDGFETSSAVLYHMLYTLGAYPEQQEKLRSEVlaald--vdkrISYEQL 355 Drosophila mojavensis
Q9VJ71    251 vsgdkwqlepindadkllsIKRLAKVAEDLLKVSLDAVASTVTFTLLEILQEPLIVEKLRAEIkelsn--engqLKFEEL 328 fruit fly

Feature 1                                   #        # #                               #      
Q27593    357 KD-----------------LKYLNQVLDETLRLYTIvPNLDRMAAKryvvp------ghpnFVIEAGQSVIIPSSAIHhD 413 fruit fly
Q9V776    367 KS-----------------LSFMGQVINETLRMHPItPYILRRTLNdyavp------dhpkYILVKELFLIIPTHAIHhD 423 fruit fly
AAK32957  345 AQ-----------------MPYLDQCINETLRKHPLaINLIRVVTEdypvp------dstgIVLPKGLNIIVPVYAIHyD 401 African malaria mo...
Q9V979    337 RE-----------------LRYTKQVLNETLRLHTPhPFLLRRATKefev-------pgsvFVIAKGNNVLIPTAAIHmD 392 fruit fly
Q9VWR2    335 GE-----------------LRYSEAALLEALRLHPAmQALQKRCTKtftlpdq-ksgasseLKVHLGTVLVLPVQAIHlD 396 fruit fly
EAT40838  347 NK-----------------LTYMERAMYETLRMHSPvFTLTKVCTKeyelppqytddvgkrITMKPGMSAIIPVHAIHlD 409 yellow fever mosquito
ABZ81072  355 QE-----------------LKYLSACILETLRKYPPvPHIDRVCNKtykl--------ndeLTIEEDIPVFVNVLAIHrN 409 domestic silkworm
EDS44706  333 SAmtyldqivngkgfdmisDVRLTLSFAESLRKYPPiPVLIRETTKnyqi-------pnttTTLEAGTPIYIPVYAIHhD 405 southern house mos...
EDW11134  356 NA-----------------LPYLDQCVYESMRMTSViGFLLKICTRptkidl----gndriLNVEPGVTVAIPAYHFHhD 414 Drosophila mojavensis
Q9VJ71    329 NG-----------------LRYMDMCLKETLRKYPPlPIIERVCRKsysl-------pnskFTIDEGKTLMVPLLAMHrD 384 fruit fly

Feature 1                                        ###   #####  ##                              
Q27593    414 PSIYpEPFEFRPERF-SPEEsag-----rpSVAWLPFGDGpRNCIGLRFGQMQARIGLALLIRNFKFstc-skTPNPLVY 486 fruit fly
Q9V776    424 PDIYpDPEEFKPDRW-SGPRdsl-----qeQGTWFGFGVGaRSCIGIQFAQLQLRLALALLLSEYEFsl---nTRKPLIN 494 fruit fly
AAK32957  402 PQHYpEPERFDPDRF-TPEGcrq-----raPYTFLPFGAGpKICIGYRQGKLQLRTMLAVLLSSYEFat--caKSTPGAL 473 African malaria mo...
Q9V979    393 PGIYeNPQRFYPERF-EEQArrs-----rpAAAFLPFGDGlRGCIAARFAEQQLLVGLVALLRQHRYaps-aeTSIPVEY 465 fruit fly
Q9VWR2    397 PALYpAPNQFRPERF-LNQPp--------mGCRFLGFGAGpRMCPGMRLGLLQTKAALTTLLQDHCVqla-deDQCRVEV 466 fruit fly
EAT40838  410 PEIYpDPCRFEPDRF-LDENrkg-----rhRYAFLGFGEGpRICLGMKFGLTQSKIGIATLLSKYRVvgs-dkQELPLEI 482 yellow fever mosquito
ABZ81072  410 EKYYpEPDQWRPERM-IGVTdnd-----nlQYTFLPFGDGpRFCIGKRYGLLQMRAAIAQMIHKYKFeaaephSTPSDPY 483 domestic silkworm
EDS44706  406 PELYpTPEKFNPERF-SMNAkr-------ePYTWIPFGEGpRACLGKQLSIMQAKIVLAYLLINFRFsig-kkCSMPLQV 476 southern house mos...
EDW11134  415 EAYFpQPDEFRPERF-DNGAise----ltkRGCLLAFGDGpRICLGMRVGLLSVKMALLRILSQYKIe-----QTKKLSL 484 Drosophila mojavensis
Q9VJ71    385 EKYFsEPMKYKPLRFlQTANdvgqcedktkSNVFIGFGIGgSQCVGQNFAKLVIKVALIKLLQNFHLeld-anQVKTLKV 463 fruit fly

Feature 1                     
Q27593    487 Dpk--sFVLGVKDGIY 500 fruit fly
Q9V776    495 LedgiaLTLMPLGVIE 510 fruit fly
AAK32957  474 Sna--hTVIKPQGDLW 487 African malaria mosquito
Q9V979    466 Dnr--rLLLMPKSDIK 479 fruit fly
Q9VWR2    467 Spl--tFLTASRNGIW 480 fruit fly
EAT40838  483 Srk--sFLLASKNGIW 496 yellow fever mosquito
ABZ81072  484 S-----VILSPKSGGR 494 domestic silkworm
EDS44706  477 Dvt--sFVLTPKNLWL 490 southern house mosquito
EDW11134  485 Ssd--sGLGMYLNGDV 498 Drosophila mojavensis
Q9VJ71    464 Shr-paPFIHTKDGLK 478 fruit fly

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