4B3F


Conserved Protein Domain Family
TIGR00376

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TIGR00376: TIGR00376 
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DNA helicase, putative
The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273041
Aligned: 6 rows
Threshold Bit Score: 851.414
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4B3F_X        17 LERDAEVEERRSWQENISLKELQSRGVCLLKLQVSsQRTGLYGRLLVTFEpRRYGSAAALP-----SnsftsGDIVGLY- 90   human
P38935        19 LERDAEVEERRSWQENISLKELQSRGVCLLKLQVSsQRTGLYGRLLVTFEpRRYGSAAALPsnsftS-----GDIVGLYd 93   human
Q57568        27 IERRCEMDFHKNEIIKLG-KKRENVGRAILNLKGK-FLGESLGCTIVRFG-RKKPFKTEIS-----P-----GDVVLVS- 92   Methanocaldoco...
P34243        15 HEREQDIQTTSRLLTTLSIQQLVQNGLAINNIHLEnIRSGLIGKLYMELG-PNLAVNDKIQrgdikV-----GDIVLVRp 88   Saccharomyces ...
WP_010878885  14 VERDAQISAMMDEIRRLSGEKRERKGRAVLGLRGK-VVGEELGFKLVRYG-RRKAIETEIS-----V-----GDEVLIS- 80   Archaeoglobus ...
WP_010877242   1 MEREAEISAMMNEIRRLSPRQRERARRAVNGLNGK-ITGRELGFHLVKYG-RRDPIDTQIS-----V-----GDLVLIS- 67   Methanothermob...
4B3F_X        91 ------------------DAaNEGSQLATGILTRVTQKSVTVAFDEs----hDFQLSLDRensYRLLKLANDVTYRRLKK 148  human
P38935        94 ------------------AA-NEGSQLATGILTRVTQKSVTVAFDEs----hDFQLSLDRensYRLLKLANDVTYRRLKK 150  human
Q57568        93 ------------------KE-NPLQSDLYANVIYVGKNFIDVAFDVd-----VPKWVYKEr--VRVDLYVNDITFKRMKE 146  Methanocaldoco...
P34243        89 aktkvntktkpkvkkvseDS-NGEQAECSGVVYKMSDTQITIALEEsqdviaTTFYSYSK---LYILKTTNVVTYNRMES 164  Saccharomyces ...
WP_010878885  81 ------------------RG-DPLKSDLRGVVVEKGSRYLTVSLES------VPEWALRD---VRIDLYASDLTFKRWIE 132  Archaeoglobus ...
WP_010877242  68 ------------------RG-NPLRSDLTGTVAMKGKRFLVVALEH------VPGWALKN---VRIDLYANDVTFQRMID 119  Methanothermob...
4B3F_X       149 ALIALKKYHSgpasSLIEVLFGRSAPSP--ASEIHPLTFFN----TCLDTSQKEAVLFALSQkELAIIHGPPGTGKTTTV 222  human
P38935       151 ALIALKKYHSgpasSLIEVLFGRSAPSP--ASEIHPLTFFN----TCLDTSQKEAVLFALSQkELAIIHGPPGTGKTTTV 224  human
Q57568       147 ALREFARKRD----KLAYIILGIEHPEKp-lREDIKLEFYD----KNLNESQKLAVKKAVLSrDLYLIHGPPGTGKTRTI 217  Methanocaldoco...
P34243       165 TMRKLSEISS----PIQDKIIQYLVNERpfIPNTNSFQNIKsflnPNLNDSQKTAINFAINN-DLTIIHGPPGTGKTFTL 239  Saccharomyces ...
WP_010878885 133 NLENLTENGK----RALKFALGLEEPSK---TECEDFKPFD----SSLNRAQLKAVGCAVSTdDFFLIHGPFGTGKTRTV 201  Archaeoglobus ...
WP_010877242 120 NLKSPTRNVL----RVLGFLCGTEKPSD--GVDVVDFQAVD----PELNESQRDAIRMALGSeDFFLIHGPFGTGKTRTL 189  Methanothermob...
4B3F_X       223 VEIILQAVKQGL--KVLCCAPSNIAVDNLVERLALc--KQRILRLGHPARLLESIQQHSLDAVLArsdSAQIVADIRKDI 298  human
P38935       225 VEIILQAVKQGL--KVLCCAPSNIAVDNLVERLALc--KQRILRLGHPARLLESIQQHSLDAVLArsdSAQIVADIRKDI 300  human
Q57568       218 TEVIVQEVKFNKh-KVLATADSNIAADNILEYLIKkypDLKVVRVGHPTRISKDLIQHSLPYLIEnheKYQEILALREKI 296  Methanocaldoco...
P34243       240 IELIQQLLIKNPeeRILICGPSNISVDTILERLTPlvpNNLLLRIGHPARLLDSNKRHSLDILSK---KNTIVKDISQEI 316  Saccharomyces ...
WP_010878885 202 VEVVRQLVKRGE--RVLVTAESNTAVDNLVELLS----DMKIVRLGHPSRVEKRLKEHTLASLVLnhpDYKRIEEIKGKI 275  Archaeoglobus ...
WP_010877242 190 HELIRQEVMRGS--RVLVTAESNAAVDNLLEGIAG---HVKCVRLGHPQRVSRENLRETLAYKIEnhpEYSKVREYQEKI 264  Methanothermob...
4B3F_X       299 DQVFVK-NKKTQDKREKSNFRNEIKLLRKELKEReE-AAMLESLTSANVVLATNTGASADGPLKLLPes----------- 365  human
P38935       301 DQVFVK-NKKTQDKREKSNFRNEIKLLRKELKER-EeAAMLESLTSANVVLATNTGASADGPLKLLPes----------- 367  human
Q57568       297 KEIKEQrDKFLKPSPRWRRGMSDEQILKVAKRKK-S-YRGIPKEKIVSMAEWIIRNKKIKRIINNLDeitekimneilae 374  Methanocaldoco...
P34243       317 DKLIQE-NKKLKNYKQRKENWNEIKLLRKDLKKR-E-FKTIKDLIIQSRIVVTTLHGSSSRELCSLYrddp--------- 384  Saccharomyces ...
WP_010878885 276 EEIERRmERLTKPSPQLRRGLSDEEILRLARSNR-G-ARGVAAKKIRSMAEWIEARKALDQLYTEMKeeeerivkeiiee 353  Archaeoglobus ...
WP_010877242 265 DELIEErERHQKPTPQIRRGLSDTQILINATKRR-G-ARGISPNVMISMARWIETNQRIDDLHSKLQeaemriadrilre 342  Methanothermob...
4B3F_X       366 -------------------yFDVVVIDECAQALEASCWIPLLKAR----KCILAGDHKQLPPTTVSHK----AalAGLSL 418  human
P38935       368 -------------------yFDVVVIDECAQALEASCWIPLLKAR----KCILAGDHKQLPPTTVSHKa--aL--AGLSL 420  human
Q57568       375 advivatnsmagseilkgweFDVIVIDEGSQAMEPSCLIPIVKGR----KLIMAGDHKQLPPTVLS-E----N--EELKK 443  Methanocaldoco...
P34243       385 ----------------nfqlFDTLIIDEVSQAMEPQCWIPLIAHQnqfhKLVLAGDNKQLPPTIKTEDdknvI--HNLET 446  Saccharomyces ...
WP_010878885 354 sd---vvistnssaflleesFDTAVIDEASQATIPSVLIPINRAR----KFILAGDHRQLPPTVMK------A--EKLSE 418  Archaeoglobus ...
WP_010877242 343 sqvvlstnssaaleyidglrFDVAIVDEASQATIPSILIPLARAP----RFILAGDHRQLPPTILSRD----A--SELER 412  Methanothermob...
4B3F_X       419 SLMERLAEEYGARv-VRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATE------ETGVPLLLVDT 491  human
P38935       421 SLMERLAEEYGARv-VRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATE------ETGVPLLLVDT 493  human
Q57568       444 TLFERLIKKYPEF--SSILEIQYRMNEKIMEFPNKMFYNNKLKADESVKNITLLDLVKEEEIDevdrdiINEIPVQFINV 521  Methanocaldoco...
P34243       447 TLFDRIIKIFPKRdmVKFLNVQYRMNQKIMEFPSHSMYNGKLLADATVANRLLIDLPTVDATPsed-ddDTKIPLIWYDT 525  Saccharomyces ...
WP_010878885 419 TLFEKLIELYPEK--SQLLNVQYRMNEKLMEFPSREFYGGRIVAHESCTAIALSQIAKREAEKlre-ilGD-EPLVFIDT 494  Archaeoglobus ...
WP_010877242 413 TLFEELIKRHPGR--SRMLNCQYRMHPAIMEFPNREFYDGRIRAHPSLEDISIRDIIEDVPDSdicqklADPDPVLFIDT 490  Methanothermob...
4B3F_X       492 AGCGL-FELEEEDEQ-SKGNPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRqsl--vhRHPELEIKSVDGFQG 567  human
P38935       494 AGCGL-FELEEEDEQ-SKGNPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRqsl--vhRHPELEIKSVDGFQG 569  human
Q57568       522 EGIER----KDKESP-SYYNIEEAEKVLEIVKKLVKYKIPTN---VITPYDAQVRYLRrlf--eeHNIDIEVNTVDGFQG 591  Methanocaldoco...
P34243       526 QGDEFqETADEATILgSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKklihdelKLTDIEISTVDGFQG 605  Saccharomyces ...
WP_010878885 495 SKCKNrWEGKLADST-SRYNRLEAEIVTEIVTELLKMGLKKEQIGVITPYDDQVDLLR-------EKVDVEVSSVDGFQG 566  Archaeoglobus ...
WP_010877242 491 SGLDG-CERRLKGST-SIQNPLEADLAVIISRSLMRMGVKPEEIGIITPYDDQVDLIS-------SMIDVEVNSVDGFQG 561  Methanothermob...
4B3F_X       568 REKEAVILSFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVN--NHAFLKTLVEYFTQHGEVRTAFE 639  human
P38935       570 REKEAVILSFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVN--NHAFLKTLVEYFTQHGEVRTAFE 641  human
Q57568       592 RENEAIVISFVRTKN---FGFLKDLRRLNVAITRAKRKLILIGNENLLK--QDKVYNEMIKWAKS---VEEEHK 657  Methanocaldococcus j...
P34243       606 REKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQrcGNKYLKSWSEWCEENADVRYPNI 679  Saccharomyces cerevi...
WP_010878885 567 REKEVIIISFVRSNRKREIGFLDDLRRLNVSLTRARRKLIMVGDSETLS--VNGTYARLIDHVKRKGVYVELDK 638  Archaeoglobus fulgidus
WP_010877242 562 REKDVIIISMVRSNRNGSIGFLKDLRRLNVSLTRARRKLIIIGDSRTLS--AHPSYRRLTEFCRKRGFLDEAGL 633  Methanothermobacter ...
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