1WZ3,4NAW,3W1S


Conserved Protein Domain Family
APG12
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pfam04110: APG12 
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Ubiquitin-like autophagy protein Apg12
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy. Covalent attachment of Apg12-Apg5 is essential for autophagy.
Links
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Statistics
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PSSM-Id: 397985
Aligned: 6 rows
Threshold Bit Score: 130.994
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WZ3_A  13 KIVVHLRATGGAPILKQSKFKVSGSDKFANVIDFLRRQLH---SDSLFVYVNSAFSPNPDESVIDLYNNFG---FDGKLV 86  thale cress
Q10931  28 KVTVRLRNIADAPVLKNKKMVVNPTDTVASFILKLRKLLNiqaNNSLFLYIDNTFAPSPDTTFETLSRCYSvkiTDKEIL 107 Caenorhabditis elegans
4NAW_I   5 KIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKlvaSEQLFIYVNQSFAPSPDQEVGTLYECFG---SDGKLV 81  human
Q9VTU1  25 KICILLNATGNVPIIKKRTWTVDPNKTVGWIQTFIHKFLKldaSEQIFLYVNQTFAPAPDQIIKNLYECHG---TNGKLV 101 fruit fly
Q9US24  46 RVNLRFKAIGRTPLLRKTVFSINASQRFEKVTRFLKKELGlpmNSSLVLYVNSSFAPSPDEIVGNLYDNFA---IDSHLL 122 Schizosaccharomyces p...
3W1S_C   8 KIQIKFQPIGSIGQLKPSVCKISMSQSFAMVILFLKRRLKm---DHVYCYINNSFAPSPQQNIGELWMQFK---TNDELI 81  Saccharomyces cerevis...

1WZ3_A  87 -VNYACSMAWG 96  thale cress
Q10931 108 eLQYSITPAYG 118 Caenorhabditis elegans
4NAW_I  82 -LHYCKSQAWG 91  human
Q9VTU1 102 -LYYCKNQAWG 111 fruit fly
Q9US24 123 -INYCINVAFG 132 Schizosaccharomyces pombe 972h-
3W1S_C  82 -VSYCASVAFG 91  Saccharomyces cerevisiae S288C
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