Conserved Protein Domain Family
Fig1

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pfam12351: Fig1 
Ca2+ regulator and membrane fusion protein Fig1
During the mating process of yeast cells, two Ca2+ influx pathways become activated. The resulting elevation of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unmated cells. Fig1 is a regulator of the low affinity Ca2+ influx system (LACS), and is also required for efficient membrane fusion during yeast mating.
Statistics
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PSSM-Id: 372065
Aligned: 27 rows
Threshold Bit Score: 68.9138
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001728035   65 LTSSS---N--GTLAPMQVRLGYFGMCGDDG-D--T--RTClsaagHYDPDEPQDIIHLtellfpqvmNNSNARGAIPEL 134 
XP_002843268   77 TIANI---V--GGAH-LEVRVGYFGICIQRNgG--G--FLC-----NQNATILAESLG-----------------VESDP 124 
EEP81331       54 AIENI---V--GRAR-LEVRVGFFGICIQKDgG--S--FLC-----NANATALAGYTQ-----------------PEDDP 101 
Q0U808         77 AIANI---V--GNAQ-LGVRVGYFGICINRDgG--G--YIC-----SNNATALVDNLN-----------------VDQDP 124  Parastagonosp...
XP_002373515   76 ATANI---V--GGAE-MEVRVGYFGICVSPSgG--A--YIC-----NSNATALAEVVT-----------------VDQDP 123 
Q0CSC3        223 VVANI------SSTGNLAVRVGYFGLCMATNtGgdPvsWIC-----RGKAKKLVALVE-----------------GVQDP 274  Aspergillus t...
XP_010759250   62 LSAGI---N--RNATSLEIRTGYLGHCMKQNsg----lWIC-----ARNAEALANAIR-------------EQKASDADP 114 
EEH10556       84 LTTGA---R--NNADSFEIRTGYLSHCLKQAsG--L--WVC-----ARDIQPLAKVIS-------------DQKKSNIDP 136 
XP_002563772   55 AVHNV---SqaGQGTTLEVRAGYMGMCVTQRhT--G--RIC-----SSNVQVLANLIQAqkp----vnNGNASTRFIPDP 118 
EED45107       75 KVYNLsqpR--NTTI-QEVRAGYMGLCLTRSdG--A--QFC-----SSNAAALASMVKD---------QGLQGSNDTADP 133 
XP_001728035  135 QNMVLTGLDLQDQ-IFGKVLLTGSALFALGLVLMfplklv----kkklakLAPGTPLTKKqqfIRRACYSTIWAGLMIVF 209 
XP_002843268  125 LNLIWVASTFKDAvVFPYLIIVALIFAFLSFLLLatfpgwhe-elnqqgsDIEVKPFPSRp--VSQVALALIFVASVFIL 201 
EEP81331      102 LNLIWVASTFKDAvVFPYLIIVALIFAFICFLILgtfpgwhe-elnddgsEREVLPFPSRp--VSQVALALIFISAVFVL 178 
Q0U808        125 LNLVWVAATFKDAvVFPYLLIVAIILAFFTFVLLatfpgwheerdeqtgsDVDVKPFPSRp--VSQVALALIFISSIFVL 202  Parastagonosp...
XP_002373515  124 LNLIWVASTFKDAvVFPYLLIVAVILAFFCFILLatfpgwhe-eidstgsEREVKPFPSRp--VSQAALALIFVASVFVL 200 
Q0CSC3        275 LNILAIADNFRDEvIVSVVIIIAIVMTLVGVYGMstfprwqdnmdddtgsEMEGTPVPSTa--ASSLIMAFESLSVLFLI 352  Aspergillus t...
XP_010759250  115 LNLLYMSKAFKDQtVFSGLIFASIPFVFICFLLLstfpgwhe-dlnssgsEQEVRPFPSRi--VSQLATVLAGLALLLIF 191 
EEH10556      137 LNLIYMSKAFKDRmVFSGLIFASIPFLFVCFLLLatfptwqd-evdsngsEVQVKPFPSKv--VSRVTTVLVVLASLLAF 213 
XP_002563772  119 LNLIMMADEFKEKiVFNGLIYIVVALMFICFLLLstfpgwhe-evgddgdERQVKPFPSEa--ALLASLLAASASSGFGL 195 
EED45107      134 LNLIWIAKNFKETiVFDGLIFIAVAVAFICFLALatfpgwhe-evdedgsEREVKPFPSRr--VSQAALGMSTLGFIFAL 210 
XP_001728035  210 AACIGTTETAGALGHATAHIKGSSILMKEGVTLQVLQWMAFGFMFLfvLTMPIMLF 265 
XP_002843268  202 VSVLWQHTASVAASTIAQDLGNGSVKSGVGTSAMLLGWFGFAFFII--VSIGLLCM 255 
EEP81331      179 VSVLWQHTASVAASTVAQDLGNGSVKSGVGTSAMVLGWFGFCLLVV--VTVGLLVM 232 
Q0U808        203 VSVLWQHTASVAAATIAQDLGNGSVKSGVGTSAMVLGWFGFVLLII--VTIGLLVM 256  Parastagonospora nodorum SN15
XP_002373515  201 VSVLWQHTASVAASTIAQDMGNGSVKSGVGSSAMVLGWFGFGLMVV--TTIGLLVM 254 
Q0CSC3        353 TAILWQHVAAVAHSATAQAAFNSIVRGNVGSVAMGLGWGSIGLKLI--VALGLMLT 406  Aspergillus terreus NIH2624
XP_010759250  192 VSVFWQHISSAAGVTMGEELNYGAVEGHIGAVSMVLGWGGVFGTAL--VFVGLIIM 245 
EEH10556      214 VSIFWQHISSSASVTMNEELYYGVVRSHSGVVAMILGWGGVFAAFL--VVLGLVVM 267 
XP_002563772  196 ITILWQHVNSSATATMAEILTYGAVSGHVGGVAMTLGWLSIGLIVL--VCVGLWAL 249 
EED45107      211 ISILWQHINSSAAGTMSESLTYGAIESHVGTAAMVLGWAAVVCLGV--VALALLVM 264 
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