4NTF


Conserved Protein Domain Family
MAPEG
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pfam01124: MAPEG (this model, PSSM-Id:395893 is obsolete and has been replaced by 460074)
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MAPEG family
This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.
Links
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Statistics
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PSSM-Id: 395893
Aligned: 181 rows
Threshold Bit Score: 34.5732
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4NTF_A                           14 LATVTLVGVLLQAYFSLQVISARRafhvsppltSg-------------PP----EFERVFRAQVNCSEYFPLFLATLWVA 76  house mouse...
CAL74641                         47 LAVALRLDLFVIVWLLASIGNVARlrffsrqdiAgaat-------tvaSE----AVRRGNAILQNTLEQAALAIAVHLGL 115 Bradyrhizobium sp. ORS 278...
dbos:1099484000100_PB2503_07102   4 VLVPVFWQVGLSISVLLLLGVHRLyd-----vvNdrsllv---rsktdTSvypeRTKKVAANFSNQFELPVLFYLACGLY 75  Parvularcula bermudensis HTCC2503...
Q2KC27                            6 IFWPLLAHVALVYGLYALLGMRRAkm-----vrAgkiak----sdyreNRdepaESLAVKNSLANQFELPVLFYACCVLL 76  Rhizobium etli CFN 42...
Q8U5J1                            7 MFWPMIAHAFLVFILYALLLHRRKnh-----tlTsreav----tqyreRGeegqASYLVNRNIANQFELPVLFHAICLLL 77  Agrobacterium fabrum str. C58...
Q0AQG8                            5 LIYPLLVQVALTFVLLFATAFLRTgs-----iaAgkvkpa---dimlgQRawpkQVQQVSNAFHNQLETPVLFFVGVILA 76  Maricaulis maris MCS10...
Q89N58                           79 VLLPVFVQVGLTFALLIGMVFGRRka-----lvSgetkir---dialgEPnwpkSTTQIANCYRNQFELPLLFYALIALA 150 Bradyrhizobium japonicum...
Q7P1E4                            1 MIYPMFALVLLTIFVGVRLGAARFan-----arSgkvkgs--yyrlmqGDappdGELKLARNFSNLFETPVLFHVFGAIV 73  Chromobacterium violaceum...
Q21LU6                            3 MLYAMFGLVVFTYVFLLVNFIWRLka-----vkSravhik--ffrrldTQdapeHILLGTRHLANLFELPVLFYVVGVLA 75  Saccharophagus degradans 2-40...
Q4PEM1                           11 LLGPLVGLSLWTFAIEGLLYYRRTpa-----lkKynidfdpekvkqekATklpaFVQWPADNFNNLLEQPTQFYAAVLGL 85  Ustilago maydis...

4NTF_A                           77 GIF-FH-EGAAALCGLFYLFARLRYFQGYARS--AQLRLTPLYASARALWLLVAMAAL 130 house mouse
CAL74641                        116 AASlHDpVPLLTTLVVLFGLGRLLFWLSYAKG--AAGRAFGFALTFSPTAFALVIGLL 171 Bradyrhizobium sp....
dbos:1099484000100_PB2503_07102  76 LLfg--vSEAAGILPWIFVIARIAHTLIHTTInvVLIRFSAFAVSVLTVIALFVRLAG 131 Parvularcula bermu...
Q2KC27                           77 YVTea-dNLPAVGLAWLFVALRYAHAAVHVTSndLSYRSPLFAAGYLTLAAMWIWLAA 133 Rhizobium etli CFN 42
Q8U5J1                           78 YITda-dNVVTVVLAWLFVISRYAHSYVHVTSnrLRYRAPLFGIGFALLVCLWGWLAI 134 Agrobacterium fabr...
Q0AQG8                           77 VVTsv-gGPVLLALSWTWVALRIVHAFIHATSnhLRWRFYCFAAGVFVLLAFWITLAI 133 Maricaulis maris M...
Q89N58                          151 LPLrh-vDLFIVLMSWVFVVTRFAHAGVFVSSndLGRRSTIWLAGVLVLLVMWIYFAL 207 Bradyrhizobium jap...
Q7P1E4                           74 IAKnl-aAPLPLALAWSYVALRAVHTAIHLSYnhPIHRFLAFLASNILLLAMWVWLAV 130 Chromobacterium vi...
Q21LU6                           76 VCLql-eSPLMIAFAWLYVGCRVVHAIIHTTYnnVVHRMLIFQLGSFILLIIWLLLVA 132 Saccharophagus deg...
Q4PEM1                           86 TLLdv-kDPLTTRLAWGYVGLRVVHSLIHVSVnkVTARFAVWATSSVVLLGMTVKLAA 142 Ustilago maydis
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