2HUP


Conserved Protein Domain Family
Rab19
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cd01864: Rab19 
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Rab GTPase family 19 (Rab19)
Rab19 subfamily. Rab19 proteins are associated with Golgi stacks. Similarity analysis indicated that Rab41 is closely related to Rab19. However, the function of these Rabs is not yet characterized. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation.
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Statistics
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PSSM-Id: 133267
Aligned: 9 rows
Threshold Bit Score: 309.364
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:The active conformation of Rab is stabilized by interations between the gamma phosphate of GTP and two critically conserved residues, Thr in switch I and Gly in switch II
  • Structure:2HUP: Human Rab43 in complex with GDP; contacts at 4.0A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #######         ##    ##                                             
2HUP_A     27 DFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEi--------------------------------- 73  human
NP_502576   8 DYLFKIVLVGDMGVGKTCVVQRFRNGTFVDRQGTTIGVDFTMKTLVv--------------------------------- 54  Caenorhabditis ele...
AAH97569   13 DFLFKLILIGDAGVGKTCVVQRFRSGVFAERQGSTIGVDFTMKTLEi--------------------------------- 59  African clawed frog
CAF95873   13 DFLFKIILVGDSNVGKTCVVQSFKSGIFMEKQQNTIGVDFTVRTIDi--------------------------------- 59  Tetraodon nigrovir...
CAG12094   13 DFLFKIILIGDSNVGKTCVVQNFKSGTFSAKQQNTIGVDFSVRTVEi--------------------------------- 59  Tetraodon nigrovir...
EAL24028   15 DYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLDidgkkvknssasiitfasiqihgqtqkmspqiwt 94  human
NP_940892  16 DFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEi--------------------------------- 62  human
AAI08533   13 DFLFKIILIGDSNVGKTCVVHRFQSGIFMDNQQNTIGVDFTVRSLNi--------------------------------- 59  African clawed frog
BAA21712   19 DFLFKIVLIGDCGTGKTCIVDRFKTGNYIERHGNTIGVDFSMKTIAv--------------------------------- 65  fruit fly

Feature 1                                #                                                    
2HUP_A     74 --------------qGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIVQLL 139 human
NP_502576  55 --------------dGKRVKLQIWDTGGQERFRTITQSYYRSANGIVLCYDITCKQSFGSLQRWIDDVSKFAAPNVVKLL 120 Caenorhabditis ele...
AAH97569   60 --------------qGKRVKLQIWDTAGQERFRTITQSYYRSANGAIIAYDITKRKSFASVPRWIEDVKKYAGSNIVQLL 125 African clawed frog
CAF95873   60 --------------dGKKVKMQVWDTAGQERFRTITQSYYRSAHGAMVAYDITRRSTFESVSHWIREVEHYGASSVVLIL 125 Tetraodon nigrovir...
CAG12094   60 --------------eGKKVKIQVWDTAGQERFRTITQSYYRSAHGAIIAYDITRHATFDSVSHWIKEVELYGASNVVLVL 125 Tetraodon nigrovir...
EAL24028   95 ksshylwepliwtllPVLLQMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGAANVVIML 174 human
NP_940892  63 --------------qGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIVQLL 128 human
AAI08533   60 --------------nGKKVKVQVWDTAGQERFRTITQSYYRSAHGAIIAYDITRRQSFESVPHWIYEAGKYGAANLMLML 125 African clawed frog
BAA21712   66 --------------eGKQIKLQIWDTAGQERFRTITQSYYRSANGVLIVYDITKRSSFSNLQKWIEEVRRYTASNVLIIL 131 fruit fly

Feature 1       ## #                            ###                                           
2HUP_A    140 IGNKSDLSELREVSLAEAQSLAEHYdi-lCAIETSAKd---------------------------SSNVEEAFLRVATEL 191 human
NP_502576 121 IGTKCDLEDQRAIEAEEAEMLQRANgm-fAMLETSAKg---------------------------NVNVDNAFLELATIL 172 Caenorhabditis ele...
AAH97569  126 IGNKSDLHESREVQLREAETLARHFdi-pCAIETSAKd---------------------------SSNVEEAFEKMATEL 177 African clawed frog
CAF95873  126 IGNKSDLQAQRQVLFEDACTLAESNgv-lAVLETSAKe---------------------------AQNVEAAFTLMAREL 177 Tetraodon nigrovir...
CAG12094  126 IGNKCDLEQEREVTFEDACNLAKNKem-lAALETSAKvirvhpsqgsvganqswcltfsswcpqeSQNVDEAFMMMAREL 204 Tetraodon nigrovir...
EAL24028  175 IGNKCDLWEKRHVLFEDACTLAEKYgl-lAVLETSAKe---------------------------SKNIEEVFVLMAKEL 226 human
NP_940892 129 IGNKSDLSELREVSLAEAQSLAEHYdi-lCAIETSAKd---------------------------SSNVEEAFLRVATEL 180 human
AAI08533  126 MGNKSDLAEKRQILFEEACTLAEKHgl-lAVLETSAKe---------------------------SHNVDEVFLLMAKEL 177 African clawed frog
BAA21712  132 VGNKCDLEEQREVDFEEARQMCQYIpeilFVMETSAKe---------------------------NMNVEDAFRCLANEL 184 fruit fly

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