5J8J,5IKK


Conserved Protein Domain Family
Arb2

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pfam09757: Arb2 
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Arb2 domain
This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Functional studies show that the Arb2 domain is necessary for centromeric heterochromatin silencing suggesting a model where the Arb2 domain, through residues N562 and Y563, acts as an anchor that connects the HDAC activity of Clr3 to the SHREC complex. SHREC (Snf2/Hdac Repressive) complex in fission yeast drives transcriptional gene silencing in heterochromatin.
Statistics
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PSSM-Id: 401634
Aligned: 43 rows
Threshold Bit Score: 299.489
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J8J_A        10 LQKAIRQQQQHYLSDEFNFVTLPLVSMDLP---DNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDN 86  Saccharomyces c...
EED24551     492 FHDVIRQYQAKKLYDNYKLTSLWIYRASISksfENQVLASSNYDKAVPLVVIFHDPPDMMGIHHPITNKLEPHNCWMADV 571
EED55241     206 LHDVIRAYQSKRLYENYKLTSLYIYRTAISrsfENQVLATPNYYQRNPLLVIFHDPPEIMGLPHPVTNKLEAHNCWLADS 285
XP_016596934 502 LHDVLRVYQSNQLYESCKLTPLHIYRTAISksfDKQVLASTNYHQRVPLIVIFHDPPEIVGQAHPVTNKLEAHNVWMADS 581
EPS34986     423 LHDVLREYQAHQLYENFKLTPLYIYRNKISksfQNQVLASANYHERVPLIVIFHDPPELMGYPDPVTSKLEAHNCWMSDA 502
EME47335     494 MHNIVREWQAEIMFTEHRMFPLSIQRQELAreyENQVLATSNYLEPRPLLLILHDPPEVLASPDPRTGRVELHNTWLTDI 573
EON61769     505 MHDIIREWQSSVMWENYGMVPLLIHHTNLSksfENQVLATRNYADANPLLVIFHDPPDVQGVPDPRTNKLELHNTYLTDV 584
EKG19671     505 IHDIVRQADANDLWNQYRMTELFILRDKISrsfEKQVLATQNFSEERPLLVIFHEPPETTALTDARSKKISLHNIFVTDV 584
KEQ76823     395 LHDIVRDYQAAWLWENLGMSSLFIAHSKASrsfKNQVLATPNHAEARPLLVIFHDPPELTGDTDPRTRELQLHNTWLTDS 474
KEQ78941     465 IHDIVREYQAGWLWENLGMSDLFIAHSKTSrsfTNQVLATSNHSESRPLLVIFHDPPDLVGTPDPRTQRLELHNTWLTDS 544
5J8J_A        87 SLDFIKWGLDRKYGIIDVNIPLt-----------LFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDSYSGI 155 Saccharomyces c...
EED24551     572 VKDYIAWAHRRNYAIIDVNIPKhvtad--ssdigKFEEDDVDRPAQTEELAGYLWDNYIEPND-ATHIFFIGVGDAFYGV 648
EED55241     286 LKDYIGWAVGKGYAVMDVNIPKhvtv----epsgKYEDEEENRPTATEELAAYLWDNYIEPNE-ATEIFFLGIGNAFYGV 360
XP_016596934 582 LTEYVEWIVGKGYAVIDVNIPKhvsre---tapgRYEADDEDRPSATEELAGYLWDNYIDANQ-ATEIFLLGVGNAFFGV 657
EPS34986     503 QKDYIGWIISKGYAVIDVNIPKhvtqv---patgKYEEEDENRPTATEELANYLWDNYIDFFDK-REVFFLGVGSAFAGV 578
EME47335     574 VKTYVDWAVRQGFAVIDVNLPRhiaeydkdnrehKETDSIESRTREATQVLTYLWENHVELNE-ATHVFLMGTNIGHGAI 652
EON61769     585 TKTYVDWAVKQGFGVIDVNIPKhytqdd-dnadyAETESQESRKALTREVATFLWENYIEPEN-ATHIFLMGIGTAYFGV 662
EKG19671     585 TKTYVEWAVKHGFGVIDVNIPEhitdpn-dlpeyAEADSDEARGLLTRELITYLWENYISLGDN-THKFFIGVGAAYSGI 662
KEQ76823     475 VKQYLQWAVDQGFAVIDINIPKhltevd-dnheyAEEADAQQRIDETELLAKYLWENYIELSD-ASHMFLMGVGQAYSSL 552
KEQ78941     545 VKQYIRWAYDRGFAVIDVNVPKhltdle-ethehAEEIDGKKTIDETQLLAKYLWDNYIELSES-KHIFMLGIGKAYTSI 622
5J8J_A       156 VHLLGHR---DTRAVTKTVINFLGDk-QLKPLVPLVDETLSEWYFKNSLIFSNNSHQCWKENe-sRKPRKKFGRVLRCDT 230 Saccharomyces c...
EED24551     649 ANLLINRd--SIYQRVNSVISFVAEn-PVRAVASPTQTWLSRWYKDNSLVFVAHTHGVWHNEn-rRKPSKRYGRLLRSPK 724
EED55241     361 ANLLINRd--TLYKRVNGVVSFVAEn-PVRAIASHTQVWLSRWYKDNSLVFVSHTHGVWNTDenrRKPSKRYGHLIQSSR 437
XP_016596934 658 SNLLINRe--NLYKRVNGVISFVSEn-PVRAVTSHTQTWLSKWYRENSLVFVSNSHGIWATPd--RRSSKRYGQLVHSPK 732
EPS34986     579 VNLLINRe--NLYKRVSGIISFVAEn-PVRAVASSTQVWLSKWYRDNSLVFVSESHAVWKDQd--RKPSKRYGTLFKSSK 653
EME47335     653 LNFIKAHe-dQAQNLMTKVISFVQDv-SLISCKSPTNDLLPGWYYSTSMVFVANDHSYWATEy-aRKPKKRFGRVSRSEE 729
EON61769     663 LDLISSHertTESDKVDLVICFVADn-PLNTVKRPADDNITNWYYDHSLVFVASDHLAWDPAr-qRKIKKRYGNLVRSSR 740
EKG19671     663 LDLMGENd--DCTKETDHIFAFVGEn-SLQSIKKLTDDYIGHWYYDSSHVFVANNHAAWDPAr-qRKLRKKYGNVLRSQH 738
KEQ76823     553 IGFLKKNd--RCRERVDKIFGFISDscALPSYRATTDDFLDRWYKDKSKIFVAQNHYVWERHk-tKAPSRKWGSLQKSDG 629
KEQ78941     623 VNFLKENd--RCRERLTKVIGFISDecTLPSYKSTTDDFLDRWYRDASKIFVATGHYVWEKHk-fKPPGKKWGTLQRSDY 699
5J8J_A       231 DGLNNIIEERFEEATDFILDS 251 Saccharomyces cerevisiae S288C
EED24551     725 TGLNEMLLQHKTEVFTWIEQR 745
EED55241     438 SGLSEMLMHHKEEVFQWIEDR 458
XP_016596934 733 SDLNEMLDEHKEEVYKWISER 753
EPS34986     654 SSLGEMMTEHQQQVFEWLADR 674
EME47335     730 SSISDMLLEHRDEIFRTLLSE 750
EON61769     741 GRITDQLIEHREQVHEALLKC 761
EKG19671     739 SDLSEMLEEHRATVTEVLLSK 759
KEQ76823     630 NDMQEMLSHHVKEVTGILGVE 650
KEQ78941     700 NDMQEMLSHHCKEVTGILTVL 720
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