Conserved Protein Domain Family
AIB

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pfam15334: AIB (this model, PSSM-Id:405920 is obsolete and has been replaced by 464654)
Aurora kinase A and ninein interacting protein
AIB is a family of eukaryotic proteins necessary for the adequate functioning of Aurora-A, a protein involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and aspects of tumorigenesis. AIB is likely to act as a regulator of Aurora-A activity.
Statistics
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PSSM-Id: 405920
Aligned: 15 rows
Threshold Bit Score: 352.969
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008527278  26 QTHLIKPSTKMPTLFPGERKVKISFTQrRTPPAGVRQTSIASFFTLQPGKTN-SDQRSVSSHVQSQTNK--ESKKDTTQQ 102 Przewalski's horse
XP_013854517  28 QTHLIKSSTKMLTLFPGERKTKISFTQrSHPPAGTRQTSIASFFTLQPGKTNgGDQKNVSSHIESQANK--ESKEDAVQL 105 pig
A4IFU8        28 QTQLIKSSTKMLTLLPGERKAKISFTQrSCPSAGTRQTSIASFLTSQQGKTNgADQRSVSSHTESQTNK--ESKEDATQL 105 cattle
ELK02118       2 QTRLMMSGTKILTPFPGERKAKFSCTQrRNLPASVRQTSITSFFTLQPGKTNgADQRSISSHIESQTNR--ESKKDATQL 79  black flying fox
XP_017202071  26 QTHLIKPSTKILTLLPEERKTNIYLTQrRTPHACVKQTSIASFFTLQPGKTNgGDQRSVPSPAERQINK--EPKNDASPL 103 rabbit
XP_005317680  27 QTHLIKPGTRMLTLFPGERKPSISFTQrKSPSVEVRQTSIASFFTSQPGMTDgGNQRSVSSHIESHINKesESKTDTTQP 106 thirteen-lined ...
XP_003471365  26 QTHLIEPSTKMLTLLPRERTPTVSLTQ-RISSAG-KQTSIASFFTLWPGMKDvGNQRSISSHTQSQINK--ESEKDTTQL 101 domestic guinea...
EHB08869      55 QTHLIKPGTKMLTLLPRERKP-VSFTQrRIPSAGIKQTSIAS-FTLKTGMTDvGNQSSVSSHTESQINK--ESKTDTTQL 130 naked mole-rat
D3ZUC4        26 QTHLLKLGTKMLTLLPGERKPSIPFTQrR----ATRQTSITSFVTSQPGMANgGNQKNASSLKENQINR--ECKSR-SQL 98  Norway rat
XP_007491393  27 QTRLSNPITRMLPPVGGERETIVGFTQrRIQPAGTRQTVIASFFTSKSGKASdGGQGRPSPGPASQRRK--EQKRDVMWL 104 gray short-tail...
XP_008527278 103 -GHPTQGLVDDCMAPP--LATSTPADIQEA-GLCPQSLQ-PSAHHRTGTPFLTVLS-----LfqPDT-SVCAGESkDSLA 171 Przewalski's horse
XP_013854517 106 -DHLIQGLEDDCMAPP--LATSTPADIQEAtRLSPKSLR-TNCHHETGIPCLTVLS-----LfqPDT-LVHAKEGkASLA 175 pig
A4IFU8       106 -EHLTQGLRADFMAPP--LATSTPADIQEA-RLSPQSLK-ASCQHGIGTPYLTVPC-----LfrPDT-SVCAGASkASLA 174 cattle
ELK02118      80 -DHLIQVLEDDCVAPP--LATSTPADIQEA-GLSPQSLQ-ASGHHRMGTPFLTVLS-----LsqSDT-LVCAEESqDSLA 148 black flying fox
XP_017202071 104 rGHLIQGSGDGCMTLP--FATSTPADIPET-GLSPQLLQ-TSGHHKMGNLLLTELS-----LlqPDT-LVCAGQSeASLA 173 rabbit
XP_005317680 107 -DHLIQDLRDNDITPP--LATSTPADIQET-ALSPLSLQ-TSGHHSLGTPFLTLLP-----LpqPAT-LVSAGENdASLA 175 thirteen-lined ...
XP_003471365 102 -DSLIQNSENDCIASS--LATSTPEDIQET-GFSDKSHK-TSGHHSVRTPFLTMPS-----LpqPNT-LACAEDNkAPLA 170 domestic guinea...
EHB08869     131 -DCLIRDSEDDCIAPP--LAMSTPEDIQET-GLSPWSHK-TSGHYNVRSPFLT--------MpqPNS-LVCAGDSkASLA 196 naked mole-rat
D3ZUC4        99 -DCLDQGLEDDCLVSP--LATSTPADIREA-GHSPQSSQ-ISGCQSLETTSLTMMS-----FpqPVV-LMGTGESkAPLA 167 Norway rat
XP_007491393 105 -DPPPLTPGDHCVRYPetTAASITKEPQEL-ICPPPSSKeVSDCCREARP--AVLSnqdqkLplPKSeIV----DsAEVG 176 gray short-tail...
XP_008527278 172 CSFTQDLESSCLLGQKEGVKDSSWKKEWLHGPKKKNCQAVERHSKPPGGKGHQPLHKTK-----FE-KVSAKEHS----- 240 Przewalski's horse
XP_013854517 176 CSFTQDMKNPCLLDQKEGE-DSSWKRDWLHGSKKNNYQSVERDSKTPGRKRHQLLDKTN-----LE-NVSSKTNSqspv- 247 pig
A4IFU8       175 CSFAHDLESSCLLDQKEGE-DSSCEREWLQGSKKNNYQSVERHSKTTGHKGHQLLDKTN-----LE-NVSAKRSRqapv- 246 cattle
ELK02118     149 CSFTQDLESSCLLDQRERE-DSSWKREWLHGSKKKNCQGMERRSKPLG-KGHQPSAKTK-----LE-KLLAKENRqasap 220 black flying fox
XP_017202071 174 FSFSQDVGRSCLLDQKEGQKDSSM-REWLHGSKK-KSQGLERHSSPARGKCPQSLDKAK-----LErKVSAKENRqvp-- 244 rabbit
XP_005317680 176 FSFTQDLESSCLLDPKEGKKDSLRKTKWLLGSK--NYQDLERDIKVPGSKCHQLLDKTK-----LEkKMSAKENRqapvc 248 thirteen-lined ...
XP_003471365 171 FSFTQNLESSCLQDQKE---DSSRKKEWFNGSE--NYQDMARHVKPPVGKCHQILDKAK-----SErKVSAKENRrpsvy 240 domestic guinea...
EHB08869     197 FS--------CLLDQK----DSSRKKEWFYGSEK-NYQGMERHIRPPGGKCHQLLDKAK-----SErKVSVKENRqrsvh 258 naked mole-rat
D3ZUC4       168 SSFTQFLERSCLLDQRE----AKRKREGLCGSKT-DCPGMGSHIRPPGGKCHQPLDKAK-----VEkRATAKENRqapvh 237 Norway rat
XP_007491393 177 FTFTQNSEGLCVLAHEL----------------------------AEGGICYRPGQETKclverAErKVFTKENKqfsvl 228 gray short-tail...
XP_008527278 241 --------------R-DFWSEENTESVKQSPCPVPVFSWDSENNDKDSCSQLFTEDSQGQRVIAHNSRAPFRDVTNNRNQ 305 Przewalski's horse
XP_013854517 248 ----------lqtyK-EFWTGADT-AVKQSPCPPPVFSWDSEKNDKDSWSQLFTEDSQGQRVIAHNSRAPFRDVTNDQNQ 315 pig
A4IFU8       247 ----------lqtyK-DSRRGANMKAVKQSSCPIPGFSWDSERNDKDSWSQLFTEDSQGQRVIAHNSRAPFRDVTNDQNQ 315 cattle
ELK02118     221 ----------fqthR-DSWSGENTEAVKQSSCAVPVFSLDSEKNDRDSWSQLFTEDSQGQQVIAHNPRAPFQDVTNNWNR 289 black flying fox
XP_017202071 245 -----------qthR-ESWNGKNT-AVKRSPCPVSVFSWDSEKNDKDSWSQLFTEDSQGQQVIAHSSRAPFRNISNSCPR 311 rabbit
XP_005317680 249 ----------lqtsR-ESWSREKTESVKQSPCLLSGFSWESEKIDKDSLSQLFTEDSQGQRVIAHDTRVPFQDLTSAWNR 317 thirteen-lined ...
XP_003471365 241 ----------lqtsR-DFCSRENTEAVKQNPCLVSVFSWHSEKNDKESWSQLFTEDSQGQRVIAHNIRAPFQDVSNTWHL 309 domestic guinea...
EHB08869     259 ----------lqtfR-ESWSRENTESVKQNRCPVSVFSWDSEKNDKESWSQLFTEDSQGQRVIAHR-RAPFQDVSNTWHQ 326 naked mole-rat
D3ZUC4       238 ----------lqtyRfGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQ 307 Norway rat
XP_007491393 229 sqgyqkskagkgenR-ESWRGEDTE-LEQRPCSSQAFSWNSERCDTDLRSQLFTEDSQGQRVIAHSSRAPFQDIYNLLRK 306 gray short-tail...
XP_008527278 306 SLGWFPNSTWAQCQD----GPTQLNLQPDVLFTQDSEGN 340 Przewalski's horse
XP_013854517 316 GLGQLPNSPWAQGQD----RTTQLNLQPDLLFTQDSEgn 350 pig
A4IFU8       316 GYGRVPNSLWAQCQD----RTTQFNLQPDSLFTQDSEGN 350 cattle
ELK02118     290 GLGQFPDSPWAQYQD----RPIQLNLQPDLFFTQDSEAp 324 black flying fox
XP_017202071 312 GLEQFADSTQALSQV----GPTQFHLPPDLLFTQDSEGN 346 rabbit
XP_005317680 318 GPGQFPTSSPAQCQD----GTIQFNLEPDLLFTQDSEAQ 352 thirteen-lined ground squirrel
XP_003471365 310 GLGCFSARPRAECQA----EHSELNQQPDLLLTQDSEGN 344 domestic guinea pig
EHB08869     327 GLGHFPTSPRAESQA----GHTQLNLQPDLLLTQDSEGN 361 naked mole-rat
D3ZUC4       308 GSGQFPDSPQAQGQD----GPTLLHLQPHLLFTQDSEGN 342 Norway rat
XP_007491393 307 PL-HTSLSPQVQCQDrsvvGTSQSNSQPDMLFTQDSQGN 344 gray short-tailed opossum
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