2G8L,2FFJ,1XFI,5F13


Conserved Protein Domain Family
ARMT1-like_dom

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pfam01937: ARMT1-like_dom 
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Damage-control phosphatase ARMT1-like domain
This domain is widely distributed in all domains of life and occur in stand-alone form and as C-terminal fusions to pantothenate kinase (PanK) in plants and animals. They are metal-dependent phosphatases involved in metabolic damage-control processes termed "damage pre-emption" or "housecleaning". S.cerevisiae Damage-control phosphatase YMR027W and the human orthologue Damage-control phosphatase ARMT1 (also known as C6orf211) are involved in response to DNA damage, a damage pre-emption function. Crystal structure of Damage-control phosphatase At2g17340 from Arabidopsis revealed a novel protein fold and several conserved residues coordinating a metal ion (probably Mg2+), which exhibits a high degree of conservation, suggesting that the metal-binding site is central for the function.
Statistics
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PSSM-Id: 396496
Aligned: 79 rows
Threshold Bit Score: 152.035
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G8L_B            15 VQYECLTCXANQCQRIVEXATQDxDIRRRAXILAAK--LLAKEYNENAIPAIa---GSLIFLELYKFLG------NDDPF 83  Pyrococcus ...
EAT15316           3 TSHRCLPCFVEQTLSVLRMTDASpQQTETILRQALS--LLSQIDFDATPPQT----ARLLHALIREKLD------NPDPY 70 
jgi:Tpet_0749      6 ADERCLICSLRQAENLLKKTITSpEKRWVIFREVFR--IMSEMKWGMKPLEV----NGEVHRFIMEYIK------ERDPF 73 
jgi:Tmel_1536      3 ATSKCLTCHVEQAQRIIDKFVTSeQEKWLILNEVLK--ELATVDFGVMPIDI----AEILYKKLEILLK------KEDLY 70 
Q3A0G8            14 IAPECFPCVVNHALSAARFAGLN-EEQAKGIVEVAEagLKESENSAILVQHV-------VRRVADAIIKakgapsSFDIY 85  Pelobacter ...
Q3B4E9            39 IPPACYPCLFQQLHSLVKITGMHeADGKRLFEHSMR--QLLETGGEGIVVQHvvrsATDLAAALMDMGGmg--edEYDPY 114 Pelodictyon...
jgi:Cpha266_1577  13 IPAACYPCIFEQLHSLAMVTGLE-GDGEKLLFEHSMlhLLATHGEGLVVQHI-------IRSATDRAIAlsgkvgDYDPY 84 
WP_012509471       3 IPAGCYSCIFEQLQSLVKVTGLD-GKSAKMLFEHSMrqLLDTHGEGLVVQHI-------IRSATDRAIAlsgkgaDYDPF 74  Pelodictyon...
Q649E9             3 TYLDCIPCFFNQALRAGRIATGDeTKLKKLLDEIGL--MLRDIPLESSPPET----GMLIYEKVREITG------VFDPY 70  uncultured ...
Q30PE6             3 IDEACVTCIINQSVKVANAIGADeLLSKKLTSTVEE--MSKSFSFSDAPPEI----ASYVYEKMAQIAN------KIDLY 70  Sulfurimona...
2G8L_B            84 IEYKLKSEEXARKVADIIKRKlk---ldFELAVKLAIIGNVIDFSVGFs-PEDLEEEVEKXLKDKL---YIDD-SKELFE 155 Pyrococcus ...
EAT15316          71 ADEKSRYQTLALQLYPKLEQQvkentdpLLTALKLSIAGNSIDHGVYH---AMDEARALQAIDSALhlpLVGD-IERLRH 146
jgi:Tpet_0749     74 KEEKRRSNDMAMKLVEMFRPEilnspdpVYSAAKLAVSGNLIDLGIPGwsVDEVFEKLHEAYERPF---DRED-FEDFRN 149
jgi:Tmel_1536     71 KLEKEKSNKIALSLYNDFKLKvmdssdpLYEAAKLAVAGNLIDFGALNnsPEEMFEKINELWAQPF---SIDD-FEYFKK 146
Q3A0G8            86 AEIKQTSNLLSLDYVESLQKKmensispLETGLQIAAAGNIIDFGAKDhaSLNLEKELRSLENVPF---TRYD-LAAFKT 161 Pelobacter ...
Q3B4E9           115 RAIKQRSNDLALTYAGEFRRKileapdqLAYGVLIAAAGNIIDFGAKQhgSLDVEAELRSLDLHEF---GRFD-FQEFSS 190 Pelodictyon...
jgi:Cpha266_1577  85 GAIKKQSNDIARQFAGEFRNKirrssepLRVAVKIAAAGNIIDFGAKRhgSLDVEKELCTIDERAF---GCFD-FAEFST 160
WP_012509471      75 GAIKKQSNVTALQFVDEFRNKirnspepLQDAVKIAAAGNIIDFGAKQhgSLDIEKELSTISERSF---GCFD-FAELSR 150 Pelodictyon...
Q649E9            71 KELKMASTEKALALYPALKDKveksndkLLTAIRIAIAGNVIDFGVNR--NFNIEEEIDIVLKKDF---AIFD-YDKFKA 144 uncultured ...
Q30PE6            71 DEVKTLSTKKALSFVPLLKEKllksqnkLLTATKIAVAGNVIDLAAEV------EFDLKEELDKIFytdFAYDdFSLFEE 144 Sulfurimona...
2G8L_B           156 EVKRAENILYITDNVGEHYFDAILIEKIREisNA-EVYIAGKEGPIINDATVEDLKRAGLEKLGKVISTGTRIVGVPLKL 234 Pyrococcus ...
EAT15316         147 DIASAESILFLADNAGEIVLDRLLIEQLPLn----KTTVVVRGTAIINDALYAEAREAGLTQIVRVLDNGDNTPGTDLSL 222
jgi:Tpet_0749    150 AIMSASTLFYVADNAGEIVFDKFFIEVLKMenPSlEVVVAVRGKPIINDATIEDAKYIGLEEIATVISSGVDEPGVMLDK 229
jgi:Tmel_1536    147 DISNSNNLLYIVDNVGEAVFDMLFIETIKQhyNDlNISVALKGYPIINDATVEDALFIGLDKFANLINTGLSTPGTNLEK 226
Q3A0G8           162 SLKTASTLLYLCDNSGEIVFDMLFIKQLQReyPDlEIVAALRDKPIINDATLADAKTVGLDRLVTTISSGSIYPGTILAE 241 Pelobacter ...
Q3B4E9           191 RLATTRRLLYICDNAGEIVFDRLFIEILKRtyPElDVTCAVRERPVINDAVASDALYIGLDEVARVVSSGSVYPGTLTEE 270 Pelodictyon...
jgi:Cpha266_1577 161 RLKLAGKLLYICDNAGEIVFDRLFIEEILRtnPGlEVTCAVRALPVINDAVLADAHDAGLDEVAVVVSSGSVYPGTLLDE 240
WP_012509471     151 RLMLAGKLLYICDNAGEIVFDRLFIEEIRRsnPGlAVTCAVRAMPVINDAVLSDAYEAGLQEVAVVISSGSVYPGTLLDE 230 Pelodictyon...
Q649E9           145 QLDKTDEILYIGDNAGESVFDRILIEEMKK-----PVLYVVRAIPAINDVTYEDAIQAGIDKVATIISSGTSAPGTVLET 219 uncultured ...
Q30PE6           145 KLQSSKSVLIIGDNVGEHIFDYMFIETLQEfyPKiKFSYMVRGTPIINDVTMKEAKEAGFDELCELIDSGVNSPGFAYSR 224 Sulfurimona...
2G8L_B           235 V---SREFXEAFNKADVIIAKGQGNFETLSEINDSRIFFLLKAKCPAVARELkVPKGALV 291 Pyrococcus horikoshii
EAT15316         223 C---RPDVRKAFDSTDLILAKGQGNYETLSEIDAN-IVFLLKAKCPVVAEHIgCQLNDAL 278
jgi:Tpet_0749    230 A---SEEFRKAFFEFDVVISKGQGNFEGLYEEEKKNLFFLLTAKCDFVAEVLnVPLGGKV 286
jgi:Tmel_1536    227 A---NQVFRDAFFEYEIILAKGQGNFEGLSDIKKNNIYFALVAKCKVISDYIkVAQGSKI 283
Q3A0G8           242 T---TDEFQDIYAAADVILSKGQGNFETLLPLADKRIFFLLRIKCDYMAALSqVERDSLV 298 Pelobacter carbinolicus DSM 2380
Q3B4E9           271 T---SPLFRQLFRDADLIISKGQGNFETLHAEADRRMFFILRIKCDPVAVLSgVAKGALV 327 Pelodictyon luteolum DSM 273
jgi:Cpha266_1577 241 T---SEEFRMLFDNADVIISKGQGNFETLLDIADERLFFILRIKCDQMARLSsVAKGELV 297
WP_012509471     231 T---SDEFRRLFDNADVIISKGQGNFETLLDVADERLFFILRIKCDQMAKLSgVAKGELV 287 Pelodictyon phaeoclathratiforme
Q649E9           220 C---NAEFKKIYKNSKLVISKGQGNYEGLSDEKQPIIFFLLKAKCWVIANDIdVNEGDII 276 uncultured archaeon GZfos35B7
Q30PE6           225 AnsyAREIF---DNVDLVISKGMGNYECMSPSHRKNICFLLKVKCAVVAAHLqKEIGDII 281 Sulfurimonas denitrificans DSM ...
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