3LQ9


Conserved Protein Domain Family
RTP801_C
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pfam07809: RTP801_C (this model, PSSM-Id:400249 is obsolete and has been replaced by 462274)
RTP801 C-terminal region
The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.
Links
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Statistics
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PSSM-Id: 400249
Aligned: 39 rows
Threshold Bit Score: 108.816
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LQ9_A        17 LAQAR-LGSRRPARLLXPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQG----KS-CH-SVGQLAL-DPSLVPTFQL 88 
XP_967998     39 LKKAK-RAHFACGEVLLPADLTRALAKDVLAKAETEPCGLKGCTIFINFESG----EE-RR-RLSVVNC-DPSTPTTFEL 110 red flour beetle
OWR50883      46 LRAAKgASDLATAEVLVPAELLARAARQALVLAEGEPCGARGAAVLVDVAGR----------RLAAFKI-DPNTVTTHEI 114 Danaus plexippu...
EFX84169      49 RLSNG-QQQRAPNEILLPAGILQSIARDILTASADEPCGIRGCMVFIDFEEPnnrnNNdRKqRIGAVKC-HPYTVNTFEL 126 common water flea
XP_001956516 133 LRAAK-SRHLTCTEVSLPCDLTPNVARDIVRVSEKEPCGIRGCTIYIEFEDEp---QN-SR-RIATIKV-DPDTVSTFEV 205 Drosophila anan...
XP_002024017 172 LRDAK-QRHLACTEVNLPADLTERIAAEIIRMSDREPCGERACTLFIEFESEp---NN-VR-RIASFKV-DPDTVSIFEL 244 Drosophila pers...
1_pfamImport   1 LRAAK-SRNLDCTEVLLPDDLLTKIAAEIYNLSEKEPCGLKGCAIFIGFEDEy---AN-MR-RIASLKM-DPNTLSTFEL 73 
Q7QGL3        13 LRIAK-RQHLACTEVLLPADLLPRISAEMFEQSEKEPCGIRGCTIYIEFEDEp---DN-TR-RIATMKT-DPNTVSTFEL 85  Anopheles gambi...
Q16ZV0       126 LRTAK-RRHLACTEVLLPADLLPRIASQMFELSEKEPCGIRGCTVYIEFEDEp---DN-SR-RIATMKT-DPTTVSTFEL 198 yellow fever mo...
XP_015795877   7 EEVLK-QTKVIQSESDLPANLTKKIAQDIIGMSETEPCGLQGCLLYISLEDE----NH-KPqTIGYVKLgEKTIVPTFVI 80  two-spotted spi...

3LQ9_A        89 TLVLRLDSRLWPKIQGLFssa-----------nspSQSL---TLSTGFRVIKKKLYS 131
XP_967998    111 YLTLRQNVNGWNHFLPQFlkk-----------mtrSGTV---MISSEYDLQKKKLYR 153 red flour beetle
OWR50883     115 HLHLEHDATNWTSLLPQFlkn-----------ltrGGTI---IISPQFTIEKKKLFR 157 Danaus plexippus plexippus
EFX84169     127 YLTLRPHTS-WTSKLPLFlqn-----------layRSTM---VISQDYSLVKRKLFR 168 common water flea
XP_001956516 206 YLTLRQDHRGWTSLLPQFmk-------------slARTI---TISPEYTITKNKLYS 246 Drosophila ananassae
XP_002024017 245 YLTLKQDKSGWTSLLPQFikn-----------ltrSNTI---NISPDFTLTKNKLYS 287 Drosophila persimilis
1_pfamImport  74 YLVIKQDGSGWHNILPQFlkn-----------lakSSTI---VISSNYELTKTKLY- 115
Q7QGL3        86 YLTLKQDRRGWTSILPQFlkn-----------larGSTI---MISPEFRLTKNKLYH 128 Anopheles gambiae str. PEST
Q16ZV0       199 YLTLRQDRSGWTSILATVsqvaiavegnfqtnypeGKTIschMGAVNGQHIDPALFS 255 yellow fever mosquito
XP_015795877  81 YLHLRRR---YSDWFKFIatrfl-------rhlfrDSSF---TIHDVYNLYKRKLFR 124 two-spotted spider mite
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