Conserved Protein Domain Family
PRK11907
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PRK11907: PRK11907 
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Links
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Statistics
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PSSM-Id: 237019
Aligned: 11 rows
Threshold Bit Score: 1415
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
116627097   2 KTDRYVTQSAVVLGLFALLTVPQVVGHADEATAPVPTTSTETvtdsgativsgqETSGTAVQGGTETVSATPTPVATNAS 81 
76786868    1 MSKHYFSKSVFALTVLTATATSGLAVQAEDIVTTPSSTATKV------------ESTTPTSTIAEEKSNVTSTPTAITDA 68 
22538078    1 MSKHYFSKSVFALTVLTATATSGLAVQAEDIVTTPSSTSTKV------------ESTTPTSTIAEEKSNVTSTPTAITDA 68 
25011967    1 MSKHYFSKSVFALTVLTATATSGLAVQAEDIVTTPSSTSTKV------------ESTTPTSTIAEEKSNVTSTPTAITDA 68 
125717119   1 -----MSKSSLQKTVALLSAAA--LAATVNAVQADENTPAVT------------ANLAPVESSAAEAKPTTAASPTEATA 61 
146321945   1 -MNFRFSKCAVALTLALLAASNPKLAQAEEILNTTPASSTEA------------SQAVPVESDTTEEADNTESPVPATTE 67 
146319749   1 -MNFRFSKCAVALTLALLAASNPKLAQAEEILNTTPASSTEA------------SQAVPVESDTTEEADNTESPVPATTE 67 
222152431   1 MRKHYVSKSAIFLAMLVATGSAQFVKAETPTTTTSPATSLTDasas----ttptTNTTSTVTPALDPNTNFTVDSSATTS 76 
253752737   1 -MNFRFSKCAVALTLALLAASNPKLAQAEEILNTTPASSTEA------------SQAVPVESDTTEEADNTESPVPATTE 67 
253756496   1 -MNFRFSKCAVALTLALLAASNPKLAQAEEILNTTPASSTEA------------SQAVPVESDTTEEADNTESPVPATTE 67 
253754563   1 -MNFRFSKCAVALTLALLAASNPKLAQAEEILNTTPASSTEA------------SQAVPVESDTTEEADNTESPVPATTE 67 

116627097  82 VEASSSSSTAQASQEASAILTNAnqvtpavpvqpeTVTEPAHEGQAVDMQILSTTDIHTNLVNYDYYQDKPSQAVGLSKT 161
76786868   69 STATSTNTTTNNQNPQPVATEAT------------TSDLKPIEGEKVDLRIMSTTDLHTNLVNYDYYQDKESQKIGLAKT 136
22538078   69 STATSTNTTTNNQNPQPVATEAT------------TSDLKPIEGEKVDLRIMSTTDLHTNLVNYDYYQDKESQKIGLAKT 136
25011967   69 STATSTNTTTNNQNPQPVATEAT------------TSDLKPIEGEKVDLRIMSTTDLHTNLVNYDYYQDKESQKIGLAKT 136
125717119  62 TTESTDPSSAISPENAIGDTDALmamar---nvaaTEDTKPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 138
146321945  68 AENPSSSETAETSDPTSETTDTTtseart-vtpaaTETSQPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 146
146319749  68 AENPSSSETAETSDPTSETTDTTtseart-vtpaaTETSQPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 146
222152431  77 TTTPSPVEAAAISPVIATAQPTTnvtsaslapaanTMATTPVEGQTVDVRIISTTDLHSNLVNYDYYQDKASQTIGLAKA 156
253752737  68 AENPSSSETAETSDPTSETTDTTtseart-vtpaaTETSQPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 146
253756496  68 AENPSSSETAETSDPTSETTDTTtseart-vtpaaTETSQPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 146
253754563  68 AENPSSSETAETSDPTSETTDTTtseart-vtpaaTETSQPVEGQTVDVRILATTDLHTNLVNYDYYQDKPVETLGLAKT 146

116627097 162 AVLIKKARETNPNTVLVDSGDTIQGTPFGTYKALIDPVAQGETHPMYKAFEMLGYDAETLGNHEFNYGLEFLDRMVKTAR 241
76786868  137 AVLIEEAKKENPNTVLVDNGDVIQGTPLGTYKAIVKPVAENEEHPMYQAMNALGYDASTLGNHEFNYGLDYLKKIIATAN 216
22538078  137 AVLIEEAKKENPNTVLVDNGDVIQGTPLGTYKAIVKPVAENEEHPMYQAMNALGYDASTLGNHEFNYGLDYLKKIIATAN 216
25011967  137 AVLIEEAKKENPNTVLVDNGDVIQGTPLGTYKAIVKPVAENEEHPMYQAMNALGYDASTLGNHEFNYGLDYLKKIIATAN 216
125717119 139 AVLIEKAKKENPNVLLVDNGDTIQGTPLGTYKAIVDPVEKGEQHPMYAALQALGFEAGTLGNHEFNYGLDYLNRVIETAG 218
146321945 147 AVLIEEAKKENPNVVLVDNGDTIQGTPLGNYKSIVDPIEEGEQHPMYAALETLGFDVGTLGNHEFNYGLAYLEKVIRTAN 226
146319749 147 AVLIEEAKKENPNVVLVDNGDTIQGTPLGNYKSIVDPIEEGEQHPMYAALETLGFDVGTLGNHEFNYGLAYLEKVIRTAN 226
222152431 157 AVLIDQAKAENPNAVLVDNGDILQGTPLGTYEALIDPLQPGEVHPMYAALDKLGFDASTLGNHEFNYGLTFIENAIASAG 236
253752737 147 AVLIEEAKKENPNVVLVDNGDTIQGTPLGNYKSIVDPIEEGEQHPMYAALETLGFDVGTLGNHEFNYGLAYLEKVIRTAN 226
253756496 147 AVLIEEAKKENPNVVLVDNGDTIQGTPLGNYKSIVDPIEEGEQHPMYAALETLGFDVGTLGNHEFNYGLAYLEKVIRTAN 226
253754563 147 AVLIEEAKKENPNVVLVDNGDTIQGTPLGNYKSIVDPIEEGEQHPMYAALETLGFDVGTLGNHEFNYGLAYLEKVIRTAN 226

116627097 242 INIINANVRNAQTGDYYYNPYKIVNKTFTDTDGKQVTLKIGITGVLPTQILVWDKANLEGKVTVDDPMEAVKTIVPQMKA 321
76786868  217 LPILNANVLDFKTHQPVFKTYDIITKTFKDSTGRSVALNIGITGIVPPQILNWDKANLEGKVTVKDSVKAIEEIVPTMRA 296
22538078  217 LPILNANVLDFKTHQPVFKTYDIITKTFKDSTGRAVALNIGITGIVPPQILNWDKANLEGKVIVKDSVKAIEEIVPTMRA 296
25011967  217 LPILNANVLDFKTHQPVFKTYDIITKTFKDSTGRAVALNIGITGIVPPQILNWDKANLEGKVIVKDSVKAIEEIVPTMRA 296
125717119 219 MPLVNANVLDPATGKFIYQPYKIIEKTFTDTQGRLTTVKIGVTGIVPPQILNWDKANLEGKVVVRDSVEAIRDIIPEMRK 298
146321945 227 MPLVNANVLDPTTKDFLYTPYTIVKKTFTDTEGKKVTLNVGVTGIVPPQILNWDKAYLEGKVIVRDAVEAVRDIIPTMRE 306
146319749 227 MPLVNANVLDPTTKDFLYTPYTIVKKTFTDTEGKKVTLNVGVTGIVPPQILNWDKAYLEGKVIVRDAVEAVRDIIPTMRE 306
222152431 237 LPILNANVFDAATGEYLFQPYAIVTKSFTDANGQAVDLKIGITGIVPPQIMLWDKANLEGKVTVKDAVQAVTEIIPTIKN 316
253752737 227 MPLVNANVLDPTTKDFLYTPYTIVKKTFTDTEGKKVTLNVGVTGIVPPQILNWDKAYLEGKVIVRDAVEAVRDIIPTMRE 306
253756496 227 MPLVNANVLDPTTKDFLYTPYTIVKKTFTDTEGKKVTLNVGVTGIVPPQILNWDKAYLEGKVIVRDAVEAVRDIIPTMRE 306
253754563 227 MPLVNANVLDPTTKDFLYTPYTIVKKTFTDTEGKKVTLNVGVTGIVPPQILNWDKAYLEGKVIVRDAVEAVRDIIPTMRE 306

116627097 322 AGADFILVAAHSGIGDNEYTKNEENEGYQIAGIEGVDAVATGHSHADFP-NGDGTSFYAKYPGVDDVNGLINGKPVVMAG 400
76786868  297 KGADVILVLSHSGIGDDRYEEGEENVGYQIASIKGVDAVVTGHSHAEFP-SGNGTGFYEKYTGVDGINGKINGTPVTMAG 375
22538078  297 KGADVILVLSHSGIGDDRYEEGEENVGYQIASIKGVDAVVTGHSHAEFP-SGNGTGFYEKYTGVDGINGKINGTPVTMAG 375
25011967  297 KGADVILVLSHSGIGDDRYEEGEENVGYQIASIKGVDAVVTGHSHAEFP-SGNGTGFYEKYTGVDGINGKINGTPVTMAG 375
125717119 299 AGADITLVLSHSGIGDDKYEKGEENEGYQIASLPGVDAVVTGHSHAEFP-SGNGTGFYEKYPGVDGINGKINGTPVTMAG 377
146321945 307 NGADIVLVLSHSGIGDDQYEVGEENVGYQIASLSGVDAVITGHSHAEFPgTAEKPSFYAKYSGVDDTNGKINGTPVTMAG 386
146319749 307 NGADIVLVLSHSGIGDDQYEVGEENVGYQIASLSGVDAVITGHSHAEFPgTAEKPSFYAKYSGVDDTNGKINGTPVTMAG 386
222152431 317 AGADIVLVLAHTGIGDDVYETGEENVGYQIASLAGVDAVVTGHSHAEFP-SGQDTGFYESYNGVDGVSGLINGTPVTMAG 395
253752737 307 NGADIVLVLSHSGIGDDQYEVGEENVGYQIASLSGVDAVITGHSHAEFPgTAEKPSFYAKYSGVDDTNGKINGTPVTMAG 386
253756496 307 NGADIVLVLSHSGIGDDQYEVGEENVGYQIASLSGVDAVITGHSHAEFPgTAEKPSFYAKYSGVDDTNGKINGTPVTMAG 386
253754563 307 NGADIVLVLSHSGIGDDQYEVGEENVGYQIASLSGVDAVITGHSHAEFPgTAEKPSFYAKYSGVDDTNGKINGTPVTMAG 386

116627097 401 KFGDHLGIMDVKLTYTDGKWKVVNSK--AKLEKIDTKSDIADKALIDMAAHDHNGTINYVRKEVGETTAPITSYFAQVQD 478
76786868  376 KYGDHLGIIDLGLSYTNGKWQVSESS--AKIRKIDMNSTTADERIIALAKEAHDGTINYVRQQVGTTTAPITSYFALVKD 453
22538078  376 KYGDHLGIIDLGLSYTNGKWQVSESS--AKIRKIDMNSTTADERIIALAKEAHDGTINYVRQQVGTTTAPITSYFALVKD 453
25011967  376 KYGDHLGIIDLGLSYTNGKWQVSESS--AKIRKIDMNSTTADERIIALAKEAHDGTINYVRQQVGTTTAPITSYFALVKD 453
125717119 378 KYGDHLGVIDLKLNYTDGKWKVTDSK--GSIRKVDTKSNVADQRVIDIAKESHQGTINYVRQQVGITTAPITSYFSLVKD 455
146321945 387 KYGDHLGVIDLNLVFKDGKWTTTSSK--AAIRKIDTKSSVADGRIIDLAKEAHNETIKYVRQQVGETTAPINSFFALVQD 464
146319749 387 KYGDHLGVIDLNLVFKDGKWTTTSSK--AAIRKIDTKSSVADGRIIDLAKEAHNETIKYVRQQVGETTAPINSFFALVQD 464
222152431 396 KYGDHIGIIDLNVSYTGGKWTVNRDKnhAEIRKIDTKSTIADADILALAQASHLGTIDYVRQTVGETTAPINSYFALVKD 475
253752737 387 KYGDHLGVIDLNLVFKDGKWTTTSSK--AAIRKIDTKSSVADGRIIDLAKEAHNETIKYVRQQVGETTAPINSFFALVQD 464
253756496 387 KYGDHLGVIDLNLVFKDGKWTTTSSK--AAIRKIDTKSSVADGRIIDLAKEAHNETIKYVRQQVGETTAPINSFFALVQD 464
253754563 387 KYGDHLGVIDLNLVFKDGKWTTTSSK--AAIRKIDTKSSVADGRIIDLAKEAHNETIKYVRQQVGETTAPINSFFALVQD 464

116627097 479 DPSIQIVNNAQLWYAKKQVAGTADENLPILSAAAPFKAGTRGDASYYTDIPAGPLAIKNVADLYLYDNVTALLKVTGAQI 558
76786868  454 DPSVQIVNNAQRWYVANELKGTPEANLPLLSAAAPFKAGTRGDATAYTDIPAGPVAIKNVADLYLYDNVTALLKVTGADL 533
22538078  454 DPSVQIVNNAQRWYVANELKGTPEANLPLLSAAAPFKAGTRGDATAYTDIPAGPVAIKNVADLYLYDNVTALLKVTGADL 533
25011967  454 DPSVQIVNNAQRWYVANELKGTPEANLPLLSAAAPFKAGTRGDATAYTDIPAGPVAIKNVADLYLYDNVTALLKVTGADL 533
125717119 456 DPSVQIVNNAQLWYAKQELAGTPEANLPILSAAAPFKAGTRGDATAYTDIPAGPIAIKNVADLYLYDNVTAILKVNGAQL 535
146321945 465 DPSVQIVNNAQIWYAKQQLAGTSEANLPILSAAAPFKAGTRGDASAYTDIPAGPIAIKNVADLYLYDNVVAILKVNGAQL 544
146319749 465 DPSVQIVNNAQIWYAKQQLAGTSEANLPILSAAAPFKAGTRGDASAYTDIPAGPIAIKNVADLYLYDNVVAILKVNGAQL 544
222152431 476 DPSVQIVNNAQLWYAKQQLAGTPEADLPLLSAAAPFKAGTRNDPTAYTDIPAGPIAIKNVADLYLYDNVTAILKLTGADI 555
253752737 465 DPSVQIVNNAQIWYAKQQLAGTSEANLPILSAAAPFKAGTRGDASAYTDIPAGPIAIKNVADLYLYDNVVAILKVNGAQL 544
253756496 465 DPSVQIVNNAQIWYAKQQLAGTSEANLPILSAAAPFKAGTRGDASAYTDIPAGPIAIKNVADLYLYDNVVAILKVNGAQL 544
253754563 465 DPSVQIVNNAQIWYAKQQLAGTSEANLPILSAAAPFKAGTRGDASAYTDIPAGPIAIKNVADLYLYDNVVAILKVNGAQL 544

116627097 559 KEWLEMSAGQFNQIDPNSKEPQQLINSSYRSYNYDVIDGLTYKFDLTQPNKYDHEGKLVNPDASRVRDLAYQGQPIDLNQ 638
76786868  534 REWLEMSAGQFNQIDPNNKAPQNIINTEYRTYNFDVIDGLTYKFDITQPNKYNKDGKVVNSQASRVRDLMYNGKPVADKQ 613
22538078  534 REWLEMSAGQFNQIDPNNKAPQNIINTEYRTYNFDVIDGLTYKFDITQPNKYNKDGKVVNSQASRVRDLMYNGKPVADKQ 613
25011967  534 REWLEMSAGQFNQIDPNNKAPQNIINTEYRTYNFDVIDGLTYKFDITQPNKYNKDGKVVNSQASRVRDLMYNGKPVADKQ 613
125717119 536 KEWLEMSAGQFNTIDPNNNQPQNLVNTDYRTYNFDVIDGVTYEFDITQPNKYDREGKLANPNASRVRNLKYQGKEIDPNQ 615
146321945 545 KEWLEMSAGQFNQVDLSSTEPQNLVNTDFRTYNFDVIDGVTYQYDITQPNKYDRDGKIVNETASRVRNLQYNGQDVTADQ 624
146319749 545 KEWLEMSAGQFNQVDLSSTEPQNLVNTDFRTYNFDVIDGVTYQYDITQPNKYDRDGKIVNETASRVRNLQYNGQDVTADQ 624
222152431 556 KEWLEMSAGQFNTIDPNVAGPQNLVNTDYRTYNFDVIDGVTYEFDVTQPNKYDAKGNLLNPNASRVRNLKFQGKEIDPNQ 635
253752737 545 KEWLEMSAGQFNQVDLSSTEPQNLVNTDFRTYNFDVIDGVTYQYDITQPNKYDRDGKIVNETASRVRNLQYNGQDVTADQ 624
253756496 545 KEWLEMSAGQFNQVDLSSTEPQNLVNTDFRTYNFDVIDGVTYQYDITQPNKYDRDGKIVNETASRVRNLQYNGQDVTADQ 624
253754563 545 KEWLEMSAGQFNQVDLSSTEPQNLVNTDFRTYNFDVIDGVTYQYDITQPNKYDRDGKIVNETASRVRNLQYNGQDVTADQ 624

116627097 639 TFLVVTNNYRATGNFPGVKDAVEKRLLNLENRQAIIDYIVSEKTINPSADGNWSFLPNIANADIRFASSDNARAHLANQD 718
76786868  614 EFMIVTNNYRASGTFPGAKNATMNRLLNLENRQTIINYIISEKTINPTADNNWGFTESIKGLDLRFQTADKAKNLVTNSK 693
22538078  614 EFMIVTNNYRASGTFPGAKNATMNRLLNLENRQTIINYIISEKTINPTADNNWGFTESIKDLDLRFQTADKAKNLVTNSK 693
25011967  614 EFMIVTNNYRASGTFPGAKNATMNRLLNLENRQTIINYIISEKTINPTADNNWGFTESIKDLDLRFQTADKAKNLVTNSK 693
125717119 616 EFIVVTNNYRSNGNFPGVREASLNRLLNLENRQAIINYILAVKNINPSADQNWHFADTIKGLDLRFLTADKAKNLIGTDG 695
146321945 625 EFIVVTNNYRANGTFPGVREASINRLLNLENRQAIINYIIAEKVINPTADNNWTFTDSIKGLDLRFLTADRAKSLVTDQE 704
146319749 625 EFIVVTNNYRANGTFPGVREASINRLLNLENRQAIINYIIAEKVINPTADNNWTFTDSIKGLDLRFLTADRAKSLVTDQE 704
222152431 636 EFMVVTNNYRASGSFPGVKNATINRLLNLENRQAIINYIVSEKTINPSADNNWYFADTIQGLDLHFLSADTSKNLIGDKA 715
253752737 625 EFIVVTNNYRANGTFPGVREASINRLLNLENRQAIINYIIAEKVINPTADNNWTFTDSIKGLDLRFLTADRAKSLVTDQE 704
253756496 625 EFIVVTNNYRANGTFPGVREASINRLLNLENRQAIINYIIAEKVINPTADNNWTFTDSIKGLDLRFLTADRAKSLVTDQE 704
253754563 625 EFIVVTNNYRANGTFPGVREASINRLLNLENRQAIINYIIAEKVINPTADNNWTFTDSIKGLDLRFLTADRAKSLVTDQE 704

116627097 719 AISYVGASTQ-AGFAEYRLIVKEKANQVEDMANKESEKLSKDaetVDQTKRVTPKVIEGSSLvkpataiqlsnsqviilP 797
76786868  694 DIQYIASSTKdEGFGDYRFVYTEQEKIDLTEPSHQEKLSQIE---KQKIHHMVATAYTKAKA-----------------S 753
22538078  694 DIQYIASSTKdEGFGDYRFVYTEQEKVDLTEPSHQEKLSQIE---KQKIHHMVATAYTKAKA-----------------S 753
25011967  694 DIQYIASSTKdEGFGDYRFVYTEQEKVDLTEPSHQEKLSQIE---KQKIHHMVATAYTKAKA-----------------S 753
125717119 696 DIVYLAASAQ-EGFGEYKFVYVAPKTEPVPIEQPSSPTIAVEaanLQHSKVDFPVLTAVDPS------------------ 756
146321945 705 CIVYLQASTAsEGFGEFKFVYTESKVVTPDEQQSDQGNTGQDivlESGQRITLPAVNPPAPA-----------------P 767
146319749 705 CIVYLQASTAsEGFGEFKFVYTESKVVTPDEQQSDQGNTGQDivlESGQRITLPAVNPPAPA-----------------P 767
222152431 716 DISYTGPSTI-EGFGDFVFTYVKPELPVATPETPQETGSQLTenrRQEIHQLATRVYNQTKA------------------ 776
253752737 705 CIVYLQASTAsEGFGEFKFVYTESKVVTPDEQQSDQGNTGQDivlESGQRITLPAVNPPAPA-----------------P 767
253756496 705 CIVYLQASTAsEGFGEFKFVYTESKVVTPDEQQSDQGNTGQDivlESGQRITLPAVNPPAPA-----------------P 767
253754563 705 CIVYLQASTAsEGFGEFKFVYTESKVVTPDEQQSDQGNTGQDivlESGQRITLPAVNPPAPA-----------------P 767

116627097 798 QAQIQETQVSSSAETLPNTGSDESMSATLAGLVLVTLAGFFGIKKYE 844
76786868  754 PNIAGTVYTQQKEKTLPKTGQEKQSYLAFFGVAILGLVGSLLKKKQI 800
22538078  754 PNITGTVYTQQKEKTLPKTGQEKQSYLAFFGVAILGLVGSLLKKKQI 800
25011967  754 PNITGTVYTQQKEKTLPKTGQEKQSYLAFFGVAILGLVGSLLKKKQI 800
125717119 757 -TNKQASHRQAGAESLPVTG-EKTSSLGLLGLVMTGLAGIFTFKKRE 801
146321945 768 QHKLASPHSQASTKTLPATG-EATSMLSLLGLTLIGFVGAWTKKKEH 813
146319749 768 QHKLASPHSQASTKTLPATG-EATSMLSLLGLTLIGFVGAWTKKKEH 813
222152431 777 ------TSSSTTKAELPKAGSQESKGLFFMGLSLLGLAGLITKKEER 817
253752737 768 QHKLASPHSQASTKTLPATG-EATSMLSLLGLTLIGFVGAWTKKKEH 813
253756496 768 QHKLASPHSQASTKTLPATG-EATSMLSLLGLTLIGFVGAWTKKKEH 813
253754563 768 QHKLASPHSQASTKTLPATG-EATSMLSLLGLTLIGFVGAWTKKKEH 813
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