Conserved Protein Domain Family
CANIN

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pfam14816: CANIN 
Coiled-coil and Nse Interacting (CANIN) domain
This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.
Statistics
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PSSM-Id: 464331
Aligned: 14 rows
Threshold Bit Score: 466.459
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN65055      569 VPVPGDVNFRFSLDDLLAEQnktvgREPRRLRDVTDELMADVrqggfarvladmEReeheGSDSDreGKLENPRHKKFVR 648 
XP_005801683  664 SSSTKPGVYKNNLDQMLKEI-----NSTKKAKEIEAQLLSACnedl-----lrlAEyeaaEENQE----EIANEHQEFLQ 729 
XP_005156665  458 AVKTKATSYRNTLEQMLQEK-----EQYQRSKELERQLLESCeedl-----mnlDE----DENSEskGEDISLEHREILQ 523 
Q8IX21        657 TGHVHPGTYTNTLERLVKEM-----EDTQRLDELQKQLQEDIrqgr-----gikSPirigEEDSTddEDGLLEEHKEFLK 726  human
XP_005048591  458 TPVISKVSYVNSLDHLLKEK-----EESRRLEEIEKILQEDIere------dnaSDg---ENEDNasGDDLLEEHRAFIK 523 
XP_421726     675 PPVGTQVSYVNSLEHLLKEK-----EQSKRLDELEKRLREDIqrke-----idsSDg---EDENAveNGDLSEEHRAFIK 741 
XP_017379417  318 FPSGGSGSYFNNLDYLLQEK-----REQALEQEQERLLLQEC------------LHlnslDTDED--EMPLTPEHRMLVE 378 
ELV11543      159 LTSGGSGSYVNSLDYLLQEK-----REQALEQEREELLLQDC------------LSlsslDLHED--EAPLSPEHRMLVE 219 
EGW06450       72 VSYGGSECYVNNLDYLLQEK-----REQALEQEWKQLLQQEH------------PNlepsECDEDyrEAVLTPEHRMLVE 134 
XP_012666502  185 STSGGSESYVNSLDYLLQEK-----REQALQQEREKLLLQNC------------SNlaslDPDED--EVLLTPEHRMLVE 245 
EEN65055      649 DRNLKKMEIPDMHPGETVFnskdmgkLFD-FPGSltLASCGLVPpldQDDPLHLLLASPDCLE-DMLTSGTLQDMYAYDV 726 
XP_005801683  730 HFSLMSAAIREIPPGEIVFnlerfgqVFHqDSLQ--LRQCHVSP---QGASQKTLIWSSPAQLrLHLNVGLFEEAYCNSP 804 
XP_005156665  524 RFSVTSCAIRDIHPGEEIFtpakfgqLFNhQTLD--LRKISVTP---HNRSQQILLQARSEHVlSLISAGLLRKAYFSFP 598 
Q8IX21        727 KFSVTIDAIPDHHPGEEIFnflnsgkIFNqYTLD--LRDSGFIG---QSAVEKLILKSGKTDQiFLTTQGFLTSAYHYVQ 801  human
XP_005048591  524 RCSVVSYVIPDKHPGEDLFdlsaagnIFTqHDLD--LRNFHFIP---QNRVEYLLLNSGLTQQlFLVVNGVLSSAYCATL 598 
XP_421726     742 RFSVVAHAIPDYHPGEDVFdlsisgkIFNqHDLD--LRNFHFIP---QSPIEKLLVSSDVTQQlFLAVHGFLST-YSCSV 815 
XP_017379417  379 KYSVSLQTIPPVHPGETVF-------LTRrHPLPciLDSSHLKP---RSHLEGLFLSSSPAQQlSFLRSGLLSTLYLHMP 448 
ELV11543      220 RFSVSLQVIPSVHPGETVF-------LPRrHPLPciLDCSNLKP---HSRLEELFLSASPSQQlSFLRSGLLSNLYLHTS 289 
EGW06450      135 KFSISLQVISPVHPGETVF-------LPRrQPLPciLDSSSLKP---HSQLEELFLRSPLPQQlSFLHKGLLSNLYLHAS 204 
XP_012666502  246 RFSVSLQAIPLVHPGKIVF-------LPRhHPLPciLDSSHLKP---RNSLEELFLSSPLAQQlSFLHNGLLSTLYLHVP 315 
EEN65055      727 -CPEPLQRWLFFLMSISRDqhVVNSAYKTLTCVLMSDw--ILEEEED-SPVWLPSLADVTRALLNYGAQLQDLYPLTSAR 802 
XP_005801683  805 -CPAQVTCFLFKMMSVHSEriISNKILRALCDIACSAayqIVNNDNQkFEVWVPSLADVTLVFMNMGAAFVTLFPFESLQ 883 
XP_005156665  599 -CQPEVTRWLFQMTSVHPNpiISSRIMQSLHTIALSAaqhIVEHKSQsFTVWVPSIRDITQVFLNMGASFISLFPLDVLQ 677 
Q8IX21        802 -CPVPVLKWLFRMMSVHTDciVSVQILSTLMEITIRN----DTFSDSpVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQ 876  human
XP_005048591  599 -CPIPILKWLFQMMSIHPDhcVSTQILSRLMELTLKN----SSINDQqFKPWIPSIADISAVFVNMGIEFRSLFPLQHFQ 673 
XP_421726     816 -CPIPILKWLFQMMSVHPSycVSTQILDRLIEITLNN----ASISDEqSKPWIPSLADVTTVLVNMGIRLRSLFPLQHLQ 890 
XP_017379417  449 dCPVPLLQWLFQLLTWPPE--TSLGAFGLLWDLSVDE---LFLQSDEdMHLWCPSLQDIREAFHSLGAYSPALYPLGPFW 523 
ELV11543      290 hCPVPLLQWLFQLLTWPPE--TSLGAFGLLWDLSVDR---LFLQSDEdMHLWCPSLQEVTEAFYSLGAYSPSLYPLGPFQ 364 
EGW06450      205 dYPRPLLQWLFKLLTWPPE--TSSRAFSLLWDLSIDG---LFRQPDEdMRLWCPSLQEVKEVFRSLGAYNPALYPQGPFR 279 
XP_012666502  316 dCPVPLLQWLFQLLTWPPE--TSVVAFSLLWDLSVDG---LFCKSDRdMHLWCPSLQEIMEAFHSLGAHDPALCPQGLCQ 390 
EEN65055      803 PsfnkedVSLPIqDAEKENQNGnvpshtsgsreGFRGLPAVNLVYILQTLSKlnapprnCTL---RVYSERDLVHLVCML 879 
XP_005801683  884 PsftegdLLEDVyLKSESPTNNs----------EEISFPEHNCTNILKYLSY-------CMGlcpHAYSNDELLLLLTVV 946 
XP_005156665  678 PpftegdLLEDFkPEENSQDSAise------ikDDATLPVHNLESVLSYLSL-------CTAlcpKAYTDEELLLLLAVV 744 
Q8IX21        877 PdfnedyLVSETqTTSRGKESEdss-----ykpIFSTLPETNILNVVKFLGL-------CTSihpEGYQDREIMLLILML 944  human
XP_005048591  674 PpfnehdILSQVqETVSQKQPRgdv-----aspAFPSLLENNLINVIKFLVF-------CTSviqDGYTDQEIWLLLVLL 741 
XP_421726     891 PnfnerdILSQMqGTVSKEQLGgftn---saspAFSSLPESNLMNVIKFLDF-------CTTvvqDGYTDEEILLLLLLL 960 
XP_017379417  524 Hsg--rvPPGEAgLSENKHQDA-----------PQEVALDISLSHIYKFLSL-------CAQaqpGAYTDENLMGLIELL 583 
ELV11543      365 Hsg--rvLNSEAsLGWDGQREA-----------PQQVALGISLNYIYKFLTL-------CAFarpGAYTDGNLLGLIELL 424 
EGW06450      280 Hst--rvLESEAsLGWWEPHNS-----------TQEVALDIKLSYIYRFLIL-------CFLvqpRSYTDANILGLMELL 339 
XP_012666502  391 Hss--reLSSEAsLSGNEQQDT-----------PQEVALDISLSYIYKFLTL-------CAVaqpGAYTDGSLMDLIELL 450 
EEN65055      880 CRILLDVQLRgLAVQFEFQSCISEILDWFEDerWPKIVADLCSSLPHLSSHHHNLLTLARHMPC-TERGRYLQRRLSLCI 958 
XP_005801683  947 GRISLDTRLI-LQSNVAVSCLLYTIINNISD--WSSVLPRVCKALTDLTDDHHNMCLLVQLLPD-SKCGKELRRHLSMCF 1022
XP_005156665  745 CRIGLETHFQ-LLPTGSFSLLLQNVLKNITD--WDVQISKACQILTDLSEDHHNLRRIVSILPE-SSRGKLLKRHLSVSI 820 
Q8IX21        945 FKMSLEKQLK-QIPLVDFQSLLINLMKNIRD--WNTKVPELCLGINELSSHPHNLLWLVQLVPNwTSRGRQLRQCLSLVI 1021 human
XP_005048591  742 FKISLEKQLK-QHFVVDFQCLFVKLLMSIKD--WDTKMPELCLAVSELSNNHHNLLWLVQLVPSlTARGREVKRRLSLVI 818 
XP_421726     961 FKISLEKQLK-HVSLIDFQCLLTKLLMSIKD--WGTKMPELCLGVSGLSSQHHNLLWLVQLVPSwITRGREVRRRLSLVI 1037
XP_017379417  584 CRTGLDVGLC-LLPKIDLQQLLLLLLENIQE--WPGKLQELCCILSWVSDHHHNLLALVQFFPDvTSRSRQLRSQLSLVI 660 
ELV11543      425 CRAGLDVGLR-LLPKTDLQQLLLQLLENIQE--WPEKLPKLCRALSWVSDHHHNLLALVQFFLDvTTRSRQLRSQLSLEV 501 
EGW06450      340 CRAGLDVGLR-LLPKTDLQQLLLLLLENIQE--WPGKLQALCCTLSWVSDHHHNLLALVQFFLDvTPRARQLRSQLSLTV 416 
XP_012666502  451 CHTGLDVGLR-LLPKADLQQLLLLLLENIQE--WPEKLQQLCSTLSRVSDHHHNLLALVQFFLDvTSRSRQLRSQLSLVV 527 
EEN65055      959 VRKLLRQGRS 968 
XP_005801683 1023 ISKLLDGNCT 1032
XP_005156665  821 ISKLLNHTCT 830 
Q8IX21       1022 ISKLLDEKHE 1031 human
XP_005048591  819 IAKLLHKRHV 828 
XP_421726    1038 IAKLLNKKHT 1047
XP_017379417  661 IARMLGQQET 670 
ELV11543      502 IARMLGQQES 511 
EGW06450      417 IARMLGQQEA 426 
XP_012666502  528 IARMLGQQET 537 
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