Conserved Protein Domain Family
CUE_CUED2
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cd14367: CUE_CUED2 
CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity. All members in this subfamily contain a CUE domain.
Links
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Statistics
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PSSM-Id: 270550
Aligned: 19 rows
Threshold Bit Score: 57.6356
Created: 26-Oct-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9H467       145 LLPGVDVLLEVFPtCSVEQAQWVLAKARGDLEEAVQMLVEGK 186 human
EKC31082     120 PNEDIQLLLEMFPnACTLEITHCLGLTKGNLESAAQLVLERA 161 Pacific oyster
XP_002415726 154 DEDTFRTLCEMFPgVCSLEVRRCLRVAGGDSEEAAQLLLLEQ 195 black-legged tick
XP_003744112 143 DEIAFDALTEMFPhKNALRIRKCLMIANGEVDTAAQLLLQDD 184 western predatory mite
Q299A9       168 FFDEAEALQEMFPdAAYVEIKHCIAISKGDIDSATQILLHRQ 209 Drosophila pseudoobscura
EHJ70478     154 YPEQCRALHEMFPnTCAMEIKHCVSIACGDAERAAATLLHRR 195 monarch butterfly
XP_002429197 170 LRSEVQMLQEMFPrSSLMEVRHCLAVADGDVERAAQIVLHRQ 211 human body louse
GAA48701      55 CDTSLDALVKMFPqVCRKQLKQCLQVADGDLGKAVNLALDRA 96  Clonorchis sinensis
ELU02516     158 TQQEADHLREMFPgASSLEINQCLCVAKGSLDEAIQLILHRQ 199 Capitella sp. I Grassle & Grassle, 1976
EFN66144     146 SWHQVALLQEMFPaASTAEARHCLAVAGGDIAKAAQLALHRQ 187 Camponotus floridanus
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