Conserved Protein Domain Family
SLC6sbd_PROT

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cd11500: SLC6sbd_PROT 
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain
PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Statistics
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PSSM-Id: 271390
Aligned: 6 rows
Threshold Bit Score: 901.811
Created: 20-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted, located in a predicted putative extracellular loop
  • Citation:PMID 7651355

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_055043     37 RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSlGPLAVWkisPLFK 116 human
XP_002126622  25 REQWGGQIEFLLSCIGYCVGLGNVWRFPYLAYENGGGAFLIPYIIMLCLCGIPLFMMELSFGQFAGlGPITAWrsvPIFK 104 Ciona intestinalis
Q99884        37 RGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSlGPLAVWkisPLFK 116 human
EEN54284      35 RDQWSAKVEYLLSMIGYCVGLGNIWRFPYLCYRNGGGAFLIPYFIMMVLAGIPMFFIELALGQYAGlGTLPVWdclPILK 114 Florida lancelet
EEN67217       5 RGQWGAKLDFMLSMLGYCVGLGNVWRFPYLCYRNGGGAFLIPYLLFLTFAGIPLFMMEMSFGQYGSlGPLTIWracPIFK 84  Florida lancelet
ACN11372      64 REQWGGKYEFLLSCIGYCVGLGNVWRFPYLCYRNGGGVFLIPYFIMLFFTGVPLFLMELSLGQYGAaGPITVWkccPLLK 143 Atlantic salmon
Feature 1                                                                                        
NP_055043    117 GAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLtsDLPWEHCGNWWNTELClehrvs--------------------kdgn 176 human
XP_002126622 105 GIGFGMVTVSFLVCIYYNVIIAWSLFYLFASFqsVLPWTLCDQWWNKESYcppqnislnasmetttqsptttagmttsim 184 Ciona intestinalis
Q99884       117 GAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLtsDLPWEHCGNWWNTELClehrvs--------------------kdgn 176 human
EEN54284     115 GIGYSMIIISSWTSIYYNMIIAWALYYLFASFtsVLPWHHCGHWWNTPSCvetv------------------------ev 170 Florida lancelet
EEN67217      85 GIGYGMVVVSGLVCIYYNVIIAWTLHFLFSSFtsALPWASCDNAWNTENCtlaa------------------------nh 140 Florida lancelet
ACN11372     144 GIGIGMLCVSMLVCLYYNVILAWTFYYLGSSFqsPLPWSCDAPANAYLCG------------------------------ 193 Atlantic salmon
Feature 1             #                                                                          
NP_055043    177 gALPLNLTc--tVSPSEEYWsrYVLHIqgSQGIGSPGeIRWNLCLCLLLAWVIVFLCilKGVKSSGKVVYFTATFPYLIL 254 human
XP_002126622 185 nATQVNKTr--lVSTTEEYWkyRVLRIdqSSGIGDPGiVLWDLVLCLLLAWIIVFAClfKGVKSTGKVVYFTATFPYIIL 262 Ciona intestinalis
Q99884       177 gALPLNLTc--tVSPSEEYWsrYVLHIqgSQGIGSPGeIRWNLCLCLLLAWVIVFLCilKGVKSSGKVVYFTATFPYLIL 254 human
EEN54284     171 aNMTANMTnftrVSPSEEYWhhRVQQY--SSSISETGkVSWELSLCLLLAWVLVFFClfKGVKSTGKVVYFTATFPYIML 248 Florida lancelet
EEN67217     141 sALDENVTr---ISPTQEYWnnRVLGI--SAGIEETGtIQWELALCLLGAWVVVFFClfKGIKSSGKVVYFTATFPYMML 215 Florida lancelet
ACN11372     194 -NATVNSSsgraLSPSEVFWneRVLGVvnSKGLHDPGpVRWPLALCLLAAWVIIFFCmlKGIRSSGKVVYVTATFPYFVL 272 Atlantic salmon
Feature 1                                                                                        
NP_055043    255 LMLLVRGVTLPGAWKGIQFYLTPQfhhLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFhqNIYRDTFIVTLGNAITS 334 human
XP_002126622 263 IILLVRGCTLEGALDGIIFYVKPDwerLKDSTVWTAAATQIFYSLGVSFGGLLTFASYNKFnnNIYRDTLIVSLGNCATS 342 Ciona intestinalis
Q99884       255 LMLLVRGVTLPGAWKGIQFYLTPQfhhLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFhqNIYRDTFIVTLGNAITS 334 human
EEN54284     249 IILLIRGAILPGAIDGVLFYVTPDfnrLTEYQVWYDAASQIFYSLAIAFGAVLTMASYNKFnnNIQRDAIMIPLINCGSS 328 Florida lancelet
EEN67217     216 IVLFLRGVTLEGAGKGLVYYLTPDfsrLADSQVWYDAASQIFYSLGIAFGGTQVMASYNKFnnNTHRDSVFIALSNCCTS 295 Florida lancelet
ACN11372     273 IVLIIRGATLEGSLQGVAFYLTPDwgrLASAQVWNDAASQVFYSLGIGVGGLLSMASYNKFdnNVIRDCLVITIGNCSTS 352 Atlantic salmon
Feature 1                                                                                        
NP_055043    335 ILAGFAIFSVLGYMSQeLGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414 human
XP_002126622 343 VFAGFVIFSVIGHMAFkVGQNVEDVIDQGPGLAFIAYPQAVALLPVPQLWSILFFFMLLTLGLDSQFAMLETVVTGFIDE 422 Ciona intestinalis
Q99884       335 ILAGFAIFSVLGYMSQeLGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDE 414 human
EEN54284     329 VFAGFAVFCFIGFMAHeLKVEVKDVVASGPGLVFIVYPEALTLLPISPVWAVCLFGMILTLGLDSMFMTVETITTALVDE 408 Florida lancelet
EEN67217     296 VFAGVVVFSILGHMAHkLDMDVKDVVANGPGLVFVAYPEALTLLPVAPLWSVLFFFMIFTVGLDTQFVMLETCITGICDE 375 Florida lancelet
ACN11372     353 FFAGFAIFSILGHMAWrKGVPVGEVADTGPGLAFVAYPEALALLPGSVFWSILFFLMLFMLGVDTLFGNMEGITTAVLDE 432 Atlantic salmon
Feature 1                                                                                        
NP_055043    415 FPYYlr--pKKAVFSGLICVAMYLMGLILTTdgGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCR-----DIH 487 human
XP_002126622 423 FPTLlr--kRKMHFTLFIAVVAFLLGILLVTegGMYWFNLYNFYSAYYGLLALSLVMCLAINWGYGFFFTYRwrfntDIK 500 Ciona intestinalis
Q99884       415 FPYYlr--pKKAVFSGLICVAMYLMGLILTTdgGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCR-----DIH 487 human
EEN54284     409 FPKLls--kYKTWMLFGFCVGMYLLGLTQCTqaGIYWLTLMDWYAAGFCLFVTAFFQAIGISWIYGIKRFSA-----NIK 481 Florida lancelet
EEN67217     376 FPHImg--kYKTWVLLVVSVVMYFLGLTCVTnaGMYWLNLMDWYSAGFSLMVLAFFMCVAISWVYGFQRFCK-----NVQ 448 Florida lancelet
ACN11372     433 FPQLranmkQKSLFLGLLCFGFYLMGLLLITdgGIYWFTLIDSFATSFGLIIITLFMCIGISFFYGVNQFCQ-----DII 507 Atlantic salmon
Feature 1                                                                                        
NP_055043    488 MMLGfk------pGLYFRACWLFLSPATLLALMVYSIVKYQPSeyg--syrFPPWAELLGILMGLLSCLMIPAGMLVAVL 559 human
XP_002126622 501 LMLGfe------pNWYFKGAWMFVTPAALIFLIIYDAINSSPItys--dykYPKWANDLGICMSVSCVAVIPIYAAWRVI 572 Ciona intestinalis
Q99884       488 MMLGfk------pGLYFRACWLFLSPATLLALMVYSIVKYQPSeyg--syrFPPWAELLGILMGLLSCLMIPAGMLVAVL 559 human
EEN54284     482 AMIGhe------pNIYFKVCWMFISPALMMFILIFSLVTYTPVkyn--gieYPSWAVNLGLLMAFSSIVMIPLVAILTIW 553 Florida lancelet
EEN67217     449 EMIGyq------pNYYFKICWAVISPMVLLFIVVFSMVVHVPAyyg--pyqYPNWAICIGWFMAMLSIVMVPLFVVLAIL 520 Florida lancelet
ACN11372     508 DMIClcppwcskvLLYFKACWVFCTPFLLLFILTYIFIEMYNTplqygayvYPRWGKALGVCMGATCCLQIPIWAIVAIS 587 Atlantic salmon
Feature 1                              
NP_055043    560 reegslwerLQQASRPAMDWGP 581 human
XP_002126622 573 lalm-rgedLKQLVLPSKRWKP 593 Ciona intestinalis
Q99884       560 reegslwerLQQASRPAMDWGP 581 human
EEN54284     554 rqegtllerVRAACRPAARWGP 575 Florida lancelet
EEN67217     521 kakgsfmerLRYACESSDDWGP 542 Florida lancelet
ACN11372     588 kesgtlkarFKKSIRPLNSWRG 609 Atlantic salmon

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