3K6S,1CK4,1AOX,3F74,2ADF,1M10,2X5N


Conserved Protein Domain Family
VWA
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smart00327: VWA 
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von Willebrand factor (vWF) type A domain
VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.
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Statistics
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PSSM-Id: 214621
Aligned: 217 rows
Threshold Bit Score: 37.8192
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3K6S_A     132 DIVFLIDGSGSIS-------------------SRNFATMMNFVRAVISQFQRp--------------STQFSLMQFSN-- 176  human
Q52359     213 AVAFVLDASGSMSgq---------------fsKGNVQSVLDRIAVLAAQFDD---------------DGEMDVWGFGE-- 260  Serratia marcescens
AAC71102   863 NLIFGIDYTASNKyqgeesfggrslhtihphvTNPYQQVISILGRTLAPFAG---------------QGRLGVYGFGDa- 926  Caenorhabditis e...
Q22422     330 DFAVAVDFTASNGnprtpgsl----hymatgiPNQYEIALRSVLTICQHYNS---------------SKTFEAYGFGAkl 390  Caenorhabditis e...
O75131     291 NFTVGVDFTGSNGdprspdsl----hyispngVNEYLTALWSVGLVIQDYDA---------------DKMFPAFGFGAqi 351  human
ADI24623  7475 NLIFGIDYTKSNFyqgertfdkrplhtidpaeMNPYQQVIQIVGKTLSSFDA---------------DGQIPAYGFGDee 7539 nematode
BAA06482    26 RVGLVLDITGSMRpl---------------ykNGTVQNVVERILAVADQFDD---------------NGLLDVWVYDN-- 73   Bacillus subtilis
NP_503069  338 DFAVAVDFTASNGppkssssl----hfmsadrPNQYELALRSVLSICQHYNSsktfeafgfgaklpnQSSVSAIFPLDlq 413  nematode
NP_628123  268 RVVLVLDASGSM----------------------SFLYSKGVVADVVERMAAvaaq--------lddDGEMQAWTFAS-- 315  Streptomyces coe...
NP_335420  483 AVALLVDTSFSMVm------------------ENRWLPMKRTALALHHLVCTrf------------rSDALQIIAFGR-- 530  Mycobacterium tu...

3K6S_A     177 -------KFQTHFTFE----------EFRRSSNPLSLLASVHQ------------LQGFTYTATAIQNVVHRlfhaSYGA 227  human
Q52359     261 -------KHKKYPNV--------------TLDNLDTYIQSIRGagkrsawenlpgLGGTNNEPPVMEEIVDY----FKDS 315  Serratia marcescens
AAC71102   927 -------KTGDWSVFNlkg----eggDCRSLDEVLNVYNTVTPtv---------aLSGPTNFAPLIYQAMEI----CQKS 982  Caenorhabditis e...
Q22422     391 p---nhqTVSAVFPLDlnrqsssvvgINGVMNAYRHALQNVT-------------LYGPTNFSPIIVEVANKaqkmMKTT 454  Caenorhabditis e...
O75131     352 p---pqwQVSHEFPMNfnp----snpYCNGIQGIVEAYRSCLPqi---------kLYGPTNFSPIINHVARFaaaaTQQQ 415  human
ADI24623  7540 ftdhgifNIAERYDLEk---------DCNGFEEVLRVYNEVTPti---------eMSGPTNFVPLIDRAIEIc---KEKH 7598 nematode
BAA06482    74 -------EFPRLKPVS----------EKDFPGYVDREILNNDRl----------hKFGRNDEPPVMKDVLRNml-rRNRA 125  Bacillus subtilis
NP_503069  414 ------rGTSEVVGI------------TGVMTAYRHALSNVQ-------------LYGPTNFAPIIENVARKaqnmIHDS 462  nematode
NP_628123  316 -------NPARLPDLPl--------gDLPKWLRLHVRVGEISLfrrgr--kkglhPEQVDMRAVGIQNEEQKviaeVRAF 378  Streptomyces coe...
NP_335420  531 -------YARTVTA------------------AELTGLAGV--------------YEQGTNLHHALALAGRH-----LRR 566  Mycobacterium tu...

3K6S_A     228 RRDA----AKILIVITDGKKEGds---------------------lDYKDVIPMADAAG--IIRYAIGVGlafqnRN--S 278  human
Q52359     316 KI------PVYVVFITDGGIS--------------------------KTRAIKDAIRRSanYPIFWKFVG-----LGgsS 358  Serratia marcescens
AAC71102   983 RD------YHILVIIADGQVTne----------------------rATRRAIVQACQHP--LSIIVVGVG-----D---G 1024 Caenorhabditis e...
Q22422     455 AR------YQILLIITDGIISD------------------------MYATINTVINASGlpLSIIIIGVG-----NE--D 497  Caenorhabditis e...
O75131     416 TASQ----YFVLLIITDGVITdl----------------------dETRQAIVNASRLP--MSIIIVGVG-----GA--D 460  human
ADI24623  7599 SY-------HILVIVADGQVTne----------------------kINQKAIAAASHYP--LSIIMVGVG-----DG--P 7640 nematode
BAA06482   126 RIl-----LSLFLSMTGAVKS-------------------------QSNRLIEASSDKP--VFWQFVGIG-----NG--N 166  Bacillus subtilis
NP_503069  463 AR------YQILLIITDGIISdm----------------------hATIRSIISASGLP--LSIIIIGVG-----NE--D 505  nematode
NP_628123  379 VRANpapvPTLVLFFSDGGVYrn----------------------aEIERELREAVEEP--VFWQFVGLG-----RS--N 427  Streptomyces coe...
NP_335420  567 HAGA----QPVVLVVTDGEPTAhledfdgdgtsvffdypphprtiaHTVRGFDDMARLG--AQVTIFRLG-----SDpgL 635  Mycobacterium tu...

3K6S_A     279 WKELNDIASKPSQEHIf-----KVEDFDALKDIQ 307  human
Q52359     359 YGILKNLDDFTDRRV-------DNTHFFAMDDFG 385  Serratia marcescens
AAC71102  1025 PWDMMRIFDESLPK--------RPWDNFHFVEFH 1050 Caenorhabditis elegans
Q22422     498 FERMHELDSDDALLqq-----dSRIAERDIVQFV 526  Caenorhabditis elegans
O75131     461 FSAMEFLDGDGGSLRSplgevaIRDIVQFVPFRQ 494  human
ADI24623  7641 WNMMGRFDDNIPK---------RLFDNFHFVDFH 7665 nematode
BAA06482   167 FDFLNKLDTLEGRVI-------DNTNFLHIEEID 193  Bacillus subtilis
NP_503069  506 FEKMHELDSDDALLqq-----dSRIAQRDIVQFV 534  nematode
NP_628123  428 YGVLERFDTLPGRRV-------DNVGFFAVDDIG 454  Streptomyces coelicolor A3(2)
NP_335420  636 ARFIDQVARRVQGRVVvp---dLDGLGAAVVGDY 666  Mycobacterium tuberculosis CDC1551
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