Conserved Protein Domain Family
DUF4589
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pfam15252: DUF4589 (this model, PSSM-Id:405849 is obsolete and has been replaced by 464592)
Domain of unknown function (DUF4589)
This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.
Links
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Statistics
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PSSM-Id: 405849
Aligned: 20 rows
Threshold Bit Score: 171.177
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004758430  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVgGPFDLGHLDFMTADILSDSW-----------EFCSFLDA 118 domestic ferret
XP_001928647  52 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGAgGPFDLGHLDFMTADILSDSW-----------EFCSFLDV 118 pig
XP_014589486  55 KVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVgGPFDLGHLDFMTADILSDSW-----------EFCSFLDV 121 horse
XP_004855554  52 EVVTQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVgGPFDLGHLDFMTADILSDSW-----------EFCSFLDV 118 naked mole-rat
XP_003755027  60 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSEKGGGsGPFDLTHLDFMTSDILSDSW-----------EFCSFLDI 126 Tasmanian devil
3_pfamImport   1 EVVHDIDTLTGDLQLEEDglTDSSKTDTLNSSSSS----------LEKMKLFPEDFIFRPPalvdpvhvnplGVLTVLKK 70 
XP_015221844  65 EVVHQIDSLTCDLQLEEEm-TDSSKTDTLNSSSSSTTTT--TASSIEKVKLHSEGQIIKALpa-------ppAILTVLKK 134 spotted gar
XP_005857150  53 EVVDQIDTLTSDLQLEDEm-TDSSKTDTLNSSSSS---T--TASSLEKIKVQANAPLIKPPah-------psAILTVLRK 119 Brandt's bat
XP_014353355   1 -------------------mTDSSKTDTLNSSSSS---T--TASSLEKAKLHSDTLIIKPPin-------cpAVLTVLRK 49  coelacanth
CAG09598       1 -VVHDIDTLTCDLQLEEDglTDSSKTDTLNSSSSSTTTTTnTASSLEKIKLFPDDCISKLMpippl-pvqpsAVLTVLKK 78  spotted green p...

XP_004758430 119 S---TPSDSVDGPELTRP----------------GAGPDYRLMN--GGTPi-----PNGPR-------VETPDSSSEea- 164 domestic ferret
XP_001928647 119 S---TPSDSVDGPESVRP----------------GTGTDYRLMN--GGMPi-----PNGPR-------VETPDSSSEea- 164 pig
XP_014589486 122 S---TPSDSVDGPESARP----------------GAGPDYRLMN--GGLPi-----PNGPR-------VETPDSSSEea- 167 horse
XP_004855554 119 S---TPSDSVDGPESSRP----------------GVGPDYRLMN--GGTPi-----PNGPR-------VETPDSSSEea- 164 naked mole-rat
XP_003755027 127 S---TPSDSGEGPEPARQ----------------PPTPDYRLMN--GGVLi-----PNGPR-------VETPDSSSEea- 172 Tasmanian devil
3_pfamImport  71 PhppLPPPRLTPPRAEDHniknlphptfvlsgniSKGAGSLMRNg-GAFPm----kPNRDLfstmpcfISSDGGIPEsgl 145
XP_015221844 135 PnppPPPPRLTPVRCDDLnktlp-------sgnpLKTNGTLLRNgaLALPgiqkkvPNGDVc-------cISKNIPEkv- 199 spotted gar
XP_005857150 120 PnppPPPPRLTPVKSEDPqrvap-------avnpVKTNGTLLRNg--GLPgapnkiPNGDIc-------cTPGSNSDka- 182 Brandt's bat
XP_014353355  50 PnppPPPPRLTPVRCEDPsktvl-------plnpVKASETLLRNg--VLPgppnkiPNGDAc-------cVPTTYPEkv- 112 coelacanth
CAG09598      79 ShppLPPPRLTPLRGEDHnvknlphptlvlsgtvSKASGSLMRNg-GVFPl----kPKRDLfsstpcfISNDGGIPEsgl 153 spotted green p...

XP_004758430 165 ----fgA---GPVKGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEEDGEE-------VVAEEevgLSPEPPRP 223 domestic ferret
XP_001928647 165 ----faA---GPVKGQLPQRTPG-------TRERVRFSDKVLYHALCCDDEEGDGEEet----aAAAEEevgLSPEPPHA 226 pig
XP_014589486 168 ----fsA---GPAKGQLPQRTPG-------TRERVRFSDKVLYHALCCDDE-GDGEE-------EAAEEeadLSPEPPRT 225 horse
XP_004855554 165 ----fsA---GPTKG---QRTPG-------TRERVRFSDKVLYHALCCDDE--------------TEEEagsLPPELPHT 213 naked mole-rat
XP_003755027 173 ----fsScppDPPKGQQAHRTPG-------TRERVRFSDKVLYHALCCDDEEGEGEE-------EQEEDgaaPSPNPPQT 234 Tasmanian devil
3_pfamImport 146 vptlprP---MPLLRHEKNKCPKargresrERERVRFSETVQYHGYCPDCDLQYDVDdtelhlqAELNN---LRLSPVHC 219
XP_015221844 200 ----piP---PLLLRPDKDRCPQa------TRERVRFSEKVQYHGYCPDCDVRYDIKnrdvhlhTEPLH---TKLKPPHH 263 spotted gar
XP_005857150 183 ----svQ---PLMHRPEKDRCPQa-----gPRERVRFNEKVQYHGYCPDCETRYNIKnrevhlhSEPVQ---PPGKLPPQ 247 Brandt's bat
XP_014353355 113 ----ptK---PLIQRPDKERCFQt-----aPRERVRFSEKVQYHGYCPDCDVRYDMKnrdvhlhSESVC---TKAKPVHC 177 coelacanth
CAG09598     154 vptlprP---MPLLRHEKNKCPKgperesrERERVRFSEKVQYHGYCPDCDLQYDVDdaelqlhAELSD---LRLSPLHC 227 spotted green p...

XP_004758430 224 EAHVGPLKPS-------------------------PAPYKPRRSPLTGrrpsstlape----qtrrvtrnssTQTVSDKS 274 domestic ferret
XP_001928647 227 EAHAGPVKPS-------------------------PAPYKPRRSPLTGrrsgpttape----qtrrvtrnssTQTVSDKS 277 pig
XP_014589486 226 EAPAGPPKPA-------------------------PAPYKPRRSPLTShrsgptvape----qtrrvtrnssTQTVSDKS 276 horse
XP_004855554 214 EPHEGALKPS-------------------------APLYKTRRSPLTSrrsgptlape----qtrrvtknssTQTVSDKS 264 naked mole-rat
XP_003755027 235 EPHVAPLKPL-------------------------LATCKPRRSPLTSrngghiptltpgsgqtrrvtrntsTQTVSDKS 289 Tasmanian devil
3_pfamImport 220 CFSSSPPPFPhqlmlengglss--shsfpptaktpPPCVPPHPPTAKP------------------------QKTILRKS 273
XP_015221844 264 C---LPPPPPlppfenggig-----isishsfppvNPGSVPHPVAPKP------------------------QKTILRKS 311 spotted gar
XP_005857150 248 GPP-RPPPPHlppfplenggp---gishsnsypplRPATVPPPTAPKP------------------------QKTILRKS 299 Brandt's bat
XP_014353355 178 CPS-PPPPPPlpplengglg-----istsnnfppvRSATVPPQTAPKP------------------------QKTILRKS 227 coelacanth
CAG09598     228 cssssppppalphelmlengglpashsfppsgttpPPCVPPHPPS-KP------------------------QKTILRKS 282 spotted green p...

XP_004758430 275 TQTLL 279 domestic ferret
XP_001928647 278 TQTVL 282 pig
XP_014589486 277 TQTAL 281 horse
XP_004855554 265 TQTVL 269 naked mole-rat
XP_003755027 290 TQTVL 294 Tasmanian devil
3_pfamImport 274 TTTTV 278
XP_015221844 312 TTTTV 316 spotted gar
XP_005857150 300 TTTTV 304 Brandt's bat
XP_014353355 228 TTTTV 232 coelacanth
CAG09598     283 TTTTV 287 spotted green pufferfish
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