Conserved Protein Domain Family
Barttin

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pfam15462: Barttin 
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.
Statistics
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PSSM-Id: 464731
Aligned: 13 rows
Threshold Bit Score: 317.917
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005607080  27 SHDRPQVYGTFYAMGSIMVIGGVIWSMCQCYPKIAFVPADADLQGILSPK-APGLVGNGLAAELK--SA--QPPYTRLWE 101
NP_001075690  27 SHDRPQVYGTFYAMGGVMVIGGVVWSMCQCYPKITFVPADSDFQGIMSPK-ALGLLDNGLAVEMK--SP--QAPYVRLWE 101
Q8WZ55        27 SHDRPQVYGTFYAMGSVMVIGGIIWSMCQCYPKITFVPADSDFQGILSPK-AMGLLENGLAAEMKspSP--QPPYVRLWE 103 human
XP_007624965  27 SHDQPQVYGTFYAMGSIMVIGGVIWSMCQCYPKITFVPADTDFQGILSPK-ALSLLESSLS-EVK--SP--QPPYVRLWE 100
XP_021582544  27 SHDRPQVYGTFYAMGSVMVMGGVIWSMCQCYPKIAFVPADSDFQGILSPK-PLGLLENGLAPEVK--SP--QAPYVRLWE 101
EHA99015      27 SHDRPQVYGTFYAMGSVMVVGGVIWSMCQCYPKVTFVPADSDFQGILSAK-A--LLENGLAAEMK--SP--QPPYTRLWE 99 
ELW67986     351 SHDRPQVYGTFYAMGGVMVIGGVIWSMCQCYPKITFVPADSDFQGILPPK-ALGLLESGLHAEMK--ST--QPPYVRLWE 425
ELK06192      27 SHDRPQIYGTFYAMGSVMVIGGIIWSMCQCYPKITFIPADSDFQGILSPRkSLGLLESGLIAE-K--SP--QPPYIRLRE 101
XP_005620308  27 SHDRPQVYGTFYAMGCVMVIGGVVWSMCQCYPKITFIPADSDFQGILSPK-ALGFLENGLAAEMK--SP--EPPYVRLWE 101
XP_008107597  27 SVEKPQIYITFCTLGVLTILIGVVWSMCQCYPKVQIVSAYSESEKFLIKKpGVLCMKNEIPEKSS--S---QTPYTSLKE 101 green anole
XP_003411210  27 SHDRPQVYGTFYAMGGAMVIGGVLWSMCQCYPKIAFVPADSEFQDTLSPK-ALGLLENKLGTEMK--SPspQPPYVRLWE 103 African savanna...
XP_013851847  27 SHDRPQVYGTFYAMGGIMVIGGVIWSMCQCYPKIAFIPADSDFQGILSPK-ALGLLENGLAAEMK--SP--QPPYARLWE 101 pig
XP_003793199  27 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPK-ALGLLENGLATEKKssq----apYVRLFE 101 small-eared galago
XP_005607080 102 EAAYDQSLPDFSHIQMKIMGCSEDPRPLL-----------------------APK--QGQPQLGASDAGEG-GPRDTQAW 155
NP_001075690 102 EAAYDQSLPDFSRIQMKVMSYSEDPRPLL-----------------------ASE--PAQLKPASSDDRGGlGPRDAQSW 156
Q8WZ55       104 EAAYDQSLPDFSHIQMKVMSYSEDHRSLL-----------------------APE--MGQPKLGTSDGGEG-GPGDVQAW 157 human
XP_007624965 101 EAAYDQSLPDFTHIQMKVLGYSEDPRPLL-----------------------AP-----EPKTGVSSGGEG-EPHTAQAW 151
XP_021582544 102 EAAYDQSLPDFSHIQMKVLGHSEDPRPLL-----------------------AP-----ETQPRTSDGEAG-GPQDAQAW 152
EHA99015     100 EAAYDQSLPDFSHIQMKALGYSEDSRMLL-----------------------AS-----EPGPRPRDTGEG-GPCDAQAW 150
ELW67986     426 EAAYDQSLPDFSHVEMRVMGCAEDPRPLL-----------------------APG--QGQPRLEGSDGGEG-GPRGAQAW 479
ELK06192     102 EAAYDQSLPDFGHIQMKVMGYGEDPHPLL-----------------------APE--LGQQQPEASDRGES-GPHDAQAW 155
XP_005620308 102 EAAYDQSLPDFSHIQMKVMGYHEDPRPLL-----------------------ASGpgQPQPQPGAGDGGEG-GPRDAQAW 157
XP_008107597 102 SEAYEKSLPSYEQVQKTVAGSEEHLGVLP-----------------------VP-----VPQIRTG--------AGVQPL 145 green anole
XP_003411210 104 DAAYDQSLPNFSHIQMKVMGYREDPRPLL-----------------------APE--PGQLQLGASDGGGG-SPVNSQAW 157 African savanna...
XP_013851847 102 EAAYDQSLPDFSHIPMKVMGYSEDPRPLLasepgqlqrgasdggeggprdxqA--------------------------W 155 pig
XP_003793199 102 EAAYDQSLPDFSHIQMKVMGYSEDPRPLL-----------------------GPQ--LGQLSLGSSDGGEG-SPQDIQAW 155 small-eared galago
XP_005607080 156 MDAAVVIHRGSDEDGGERSPTQSR------PGPPACPQGSAPLASFPDDLDTGSSEG-----------GSPRPSPP-EGE 217
NP_001075690 157 VEAAVVVHRGSDEKEGGRTPSQSR------PGPPACPQGPAPLASFQDDLEVGSSEG-----------SSPRPSPA-NGE 218
Q8WZ55       158 MEAAVVIHKGSDESEGERRLTQSW------PGPLACPQGPAPLASFQDDLDMDSSEG-----------SSPNASPH-DRE 219 human
XP_007624965 152 MEAAVVVHRGLDEKEGERPGTQSS------P--PACSQGSAPLASFQDDLDMGSSEG-----------SSPHPSPP-NRE 211
XP_021582544 153 VEAAVVVHRGLDENEEERHRTQNR------PGSPACPQGPAPLASFQDDLDLGSSEG-----------SSPNPSPP-AGK 214
EHA99015     151 VEAAVVVHRGVDQSEGERTRTQSS------PSLTGYHQGPAPLASFQDDLDMGSSEG-----------SSPAPSPP-GRA 212
ELW67986     480 MEATVVVHRGSDENEGERSPARSR------LGSPGCSQGPAPLASLQDDLDLGSSDG-----------SSPNPSPP-DGE 541
ELK06192     156 MEAAVVVHRGSDEDEGERIPPQSR------PGPPACPHGPAPLASFQDDLDVDSSEG-----------DIPNPSPC-EAE 217
XP_005620308 158 MEATVVIHRGSDEDEGGSQPTPSR------PGLQACPQGPAPLASFRDDLDMDSSEG-----------GSPNPSPP-EGE 219
XP_008107597 146 VQAKAEVHRNSENDRGTYKYPESQkgatklHSQSKMSKSQAPLASLQEEMDASSMES-----------ASNSPFLQrWKS 214 green anole
XP_003411210 158 VESAVVVHRSSDEDKGERIPAESSp----gP--PACPPGPAPLASFQEDLDVGSSKG-----------SSPSPSPP-NGE 219 African savanna...
XP_013851847 156 LEAAVVIHRGSDQDEGERRPSQGR------PSPQTCPQGPAPLASFQDDLDVGSSEGsxpnlsppqevELPLPPPe---- 225 pig
XP_003793199 156 TEAAVVVHRGSDENEGERDPTQSR------PGPPTCPQGPAPLASFQEDLDMGSSED-----------SSPNPSPP-DRE 217 small-eared galago
XP_005607080 218 QP-------PACRCRLDPFHDFALIDA-PTSED 242
NP_001075690 219 EPppppgepWACRSPPDRFHDFALIDEvPTSED 251
Q8WZ55       220 EAcspqqepQGCRCPLDRFQDFALIDA-PTLED 251 human
XP_007624965 212 EPhpq--vpWASMGPLDRFSDFALIDDtPTSED 242
XP_021582544 215 EPhplaqkhQACRGTRDHFYDFALIDD-ASvse 246
EHA99015     213 APwppqqepRASRSPLDDSHDFALIDD-PSTpe 244
ELW67986     542 EPrpppqepWACRCPLDHFHDFALIDA-PT-ED 572
ELK06192     218 EPgpqprepWAGRCWLDRFHDFALIDD-PTLED 249
XP_005620308 220 GPhppprepWACRCQLDRFHDFALIDA-PTPED 251
XP_008107597 215 APntvfpteNQLRYQLPCYEDFALIDS-VTTEG 246 green anole
XP_003411210 220 EPrlpppdpWACRCQLDRFHDFALIDS-ATSGD 251 African savanna elephant
XP_013851847 226 --------pWACRCQLDRFHDFALIDA-PTLED 249 pig
XP_003793199 218 EPrpptqepKAYWCQLDRYSDFALIDA-PTAED 249 small-eared galago
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