3CA8


Conserved Protein Domain Family
YdcF-like
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cd06259: YdcF-like 
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YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.
Links
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Statistics
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PSSM-Id: 99750
Aligned: 448 rows
Threshold Bit Score: 58.4791
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:highly conserved residues within the family; YdcF has been shown to bind AdoMET
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3CA8_A        38 DCVILAGNAvm--------------------------------------------------ptIDAACKIARDq------ 61  Escherichia col...
Q8G346        77 TVFVVFGLGtqtvneqghnt---------------------------------vepltfsygsIFAAARFYHEcqss--g 121 Brucella suis
YP_001368679  68 TAFIVFGMGtqtvdgdgqk----------------------------------vveplafsygPILAAVAMNRqcve-kg 112 Ochrobactrum an...
Q9KLZ5         6 PIYVVLGKRlnanqltl--------------------------------------egksrvdgLISALQCHENt------ 41  Vibrio cholerae
ZP_01062703    5 HLLIVLGKRlnenklt-----------------------------------------negisrVDALVEYLAGplaeesn 43  Vibrio sp. MED222
Q7MF23         5 RLVIVLGKRlfknalt-----------------------------------------pegvsrVDALVDAMASgki---e 40  Vibrio vulnific...
ZP_01869925    8 QLIVVLGKRlnnnaltl--------------------------------------egmsrveeILRHVGSSDCs------ 43  Vibrio shilonii...
Q87JJ4         5 NVVIVLGKRlvnnqls-----------------------------------------aegisrVEALAAKIREmpm---- 39  Vibrio parahaem...
YP_001279675  86 TAYVVLGGGlteadhkpnrqksaiankgsdthvanrppsspaqkntpqlspnsivlnqyslnrMQTVIWHYKKk------ 159 Psychrobacter s...
YP_784623     42 SAAIVFYTPdeav----------------------------------------------ratyVRRAHDLYRAgq----- 70  Bordetella aviu...

Feature 1                                                                               #  #     
3CA8_A        62 -qIPLLISGGighsttflysaiaqhphyntirttgraEATILADIAHqfwh-----ipheKIWIEDQSTn-CGENARFSI 134 Escherichia col...
Q8G346       122 vsCTFITTGAdvag-------------------tgvsEAASTAAELEkagv------dsrAIIQDDRPHn-AWTTARNVA 175 Brucella suis
YP_001368679 113 frCKFIASGAdvag-------------------tgvsEAASIATQLEkagv------dpaSVLLDEKSRn-SWQNSRNVA 166 Ochrobactrum an...
Q9KLZ5        42 -aARVVFCGGitlg-------------------qtvsEAKRMHEYFEqrrqqlglsfpqiDVLLEQESTs-TVENIEHVA 100 Vibrio cholerae
ZP_01062703   44 qqTAVAFCGGvtqg-------------------qtvsEADMMHEYFRelenqleypfpigAVLLEQHSTn-TVENIQNLA 103 Vibrio sp. MED222
Q7MF23        41 pgSRIAFCGGitqg-------------------qtrsEAIAMFDYFQqrchannltfsaqNILLEERSTs-TVENIFEVS 100 Vibrio vulnific...
ZP_01869925   44 -sSIIAFCGGvtng-------------------qsvsEARLMFEAFEaglssm-dnsnigAVLLEEESTs-TVENIIHLS 101 Vibrio shilonii...
Q87JJ4        40 enTALVFCGGktqg-------------------qsisEADAMYAYFQtlntslakpfptsQTLLENRSLn-TFENMRNAA 99  Vibrio parahaem...
YP_001279675 160 -pLPIILTGV---------------------------EAPWMRDWLLnyg--------idNIITENASMn-TCENARFTA 202 Psychrobacter s...
YP_784623     71 -vGMIVCVGGarpg-------------------rnyfGSAVMADELErsgv------pagALHCGDRVSddSRSNIQAAW 124 Bordetella aviu...

Feature 1                              #   #  #                                                  
3CA8_A       135 ALLNqaver------vhtaIVVQDPTMQRRTMATFRRMTgdnp---------------------daprWLSYPGfvpqlg 187 Escherichia col...
Q8G346       176 ATLRelk----------paRVVVLQPAPMMGRTLLYLAHf---------------------------gIKPEPVatsylt 218 Brucella suis
YP_001368679 167 AILReir----------paKVVLLQAAPMMKRDLLYLAHf---------------------------gVKPEPVaagylt 209 Ochrobactrum an...
Q9KLZ5       101 QVLLesgvvqr--getlalTLVSNDYHLKRIFEIQQLMDeqgllrkliercaqsgvrleiardlkahlCVPYPHqnpqg- 177 Vibrio cholerae
ZP_01062703  104 SEMIesglftr--gqsvtvTFVSNDYHLQRIFEIQSLMDeqgllkvlvekcsalgvelqidpqreahvAVPYPHqteqg- 180 Vibrio sp. MED222
Q7MF23       101 RLLNqsgqcsa--gsvlkvTFVSNDYHLKRIFEIQQLMDeqgllrvlrercaqhgvhldihhdleahvSVPYPNvggea- 177 Vibrio vulnific...
ZP_01869925  102 EVLLesellqn--gakievKFVSNDYHLERMFTIQSLLDsqgllrylksecqraglnltissdikshfPVPYPHhcvng- 178 Vibrio shilonii...
Q87JJ4       100 KVLCesglfplpsqatvevILLSNVYHLERILEIQTLMDeqgllrviksqcasvgldlhisldiqkhiSVPYPHqgpqa- 178 Vibrio parahaem...
YP_001279675 203 KRLNls-----------dvYLITDAYHMTRTRRQFALNNiht-----------------------spiVAPLPMqkswlh 248 Psychrobacter s...
YP_784623    125 AVLNardf--------qdaVLVADRLHGFRLRYLAHMLTgqs------------------------prWAAAPDylswe- 171 Bordetella aviu...

Feature 1                                   #    
3CA8_A       188 nnadsvifinqlqglwpverylslLTGELPRL 219 Escherichia coli K12
Q8G346       219 vngsth------fstslsflamdlALNEEIGA 244 Brucella suis
YP_001368679 210 gshtnm------sspglyflmtdlALHEEIGV 235 Ochrobactrum anthropi ATCC 49188
Q9KLZ5       178 --------------------lrflWVDELTTY 189 Vibrio cholerae
ZP_01062703  181 --------------------qlflLMDALTTY 192 Vibrio sp. MED222
Q7MF23       178 --------------------qlflLIDELTTY 189 Vibrio vulnificus YJ016
ZP_01869925  179 --------------------qlflLLDELTTY 190 Vibrio shilonii AK1
Q87JJ4       179 --------------------eaflLLDELTTY 190 Vibrio parahaemolyticus
YP_001279675 249 pk--------------dnaqhsrrTLYELAAY 266 Psychrobacter sp. PRwf-1
YP_784623    172 -------------------qallrAYWELLAW 184 Bordetella avium 197N

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