4NAD


Conserved Protein Domain Family
CREPT
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pfam16566: CREPT 
Cell-cycle alteration and expression-elevated protein in tumour
CREPT (Cell-cycle alteration and expression-elevated protein in tumour) is a family of eukaryotic transcriptional regulators that ptromote the binding of RNA-polymerase to the CYCLIN D1, CCDN1, promoter and other genes involved in the cell-cycle. It promotes the formation of a chromatin loop in the CYCLIN D1 gene, and is preferentially expressed in a range of different human tumours.
Links
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Statistics
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PSSM-Id: 465181
Aligned: 25 rows
Threshold Bit Score: 165.487
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4NAD_A         6 EELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARM 85 
XP_002108989 171 EELVRCLSDLEQSASGDVVIRKKISELPKEFEDVGSVDSIQSKAEAEKLLKKVDEAVLLLADYNGRLTAELEDRAQGLRK 250
CTP80865     211 EDVISLLKKLEDPPSADAETRQLIASFPETIANPALLKPIRNESQAMELLKKIKEAEPVVKEYCKRLAAEMEDRRFLQQL 290
A8WLG6       166 QDVLVSLKRLQNPPSTERDIRIQLSKYPDNISCPEKLQSVQNSEEAKALLTQNEEALPMLEDYVKRLKEETKERESLETN 245 Caenorhabditis ...
XP_003384644 187 lKLMTSVDG-EKSAIQDMALRQRIANFPSHLYDVDILSKLKSKEACQELLEEVKEPLEILSQYTKKMEDELKERQEIEQL 265
XP_002427101 186 EEIIKALMDLENSASSDVAVREAIASLPPEVSDVSLLIKLQDRAAAENLSKQVNAAAQLVSEYNARLSAELEDRKKVTAL 265
1_pfamImport   1 DELIKALLELENSASVDVAVREKISKLPPEVSEVKLLAKLEDKETALKLAERVNAALELLTEYNNRLGMEMDERRKVQQM 80 
EFN78446     190 EELIKALMDLENTASSDAGVRERIASLPPEVSEVSLLANLADRAAADQLSVAVNEAAALLADYNGRLQAEMEDRRRLLTM 269
XP_028029177 201 EELIKALLELESSASSDEAVRERIASLPPEVSEVQLLSKLEDKESALSLSAVVNSAVELLAEYNLRLTEELEKRRKVAGM 280
EDS39626     234 EELIRVIQELENSASSDAAVRERIANLPPEVSELSALAKLEDKEAAMRLAVKVNDAIKILNDYNARLASEMDDRKKLTTM 313

4NAD_A        86 LVEYTQNQKDVLSEKEKKLEEYKQKLARVTQVRKELKSHIQSLPDLS-LLPNVTGGLAPLPSAGDLFS 152
XP_002108989 251 LDELITIHQAELEKTEKELEKCKTKLATTAKVKKELKIHIESLPDLS-LLPDVTGGLAPLPAANDLFS 317
CTP80865     291 LPEYFGFLKASAVRNDEMLRSVREKVEKLEQEKTSVKEHFDSLPDLA-DLP--SSALPPLPSLGELFK 355
A8WLG6       246 LNMLIQNVRMSIEHHEKLCRDVKRKEDRIKADLLEVEKTFESLPDLTaEMPN-----APLPTLEALFQ 308 Caenorhabditis briggsae
XP_003384644 266 LESFLWLHQCLLYKARERQKDYRQKMEQCQHVKVTLNSHIASLPDLA--APN-SDSLAPLPSIGDLFS 330
XP_002427101 266 LRDFTESQNELLSHAKQRLEEYQEKLQKIHQVRQEVRSHLQNLPDLT-QLPDVTGGLAPLPSAGDLFS 332
1_pfamImport  81 LHDYTISQKQLLQQAEARLEEYKEKLIKVEQVRHEVMSHLNNLPDMK-QLPDVTSGLAPLPSAGDLFT 147
EFN78446     270 LRDYTLAQRQLLQQAQSTLEDYKEKLKKVCAVRTEVKSHISNLPDLT-QLPDVTGGLAPLPSAGDLFS 336
XP_028029177 281 LRDFAQAQRDLAKQAETRLEEYNVKLQKIYAVKAEVKHHIENLPDVS-RLPDVTGGLAPLPSAGDLFS 347
EDS39626     314 LKDFQREQQELLAQAEQRLEEYTSKLSKIKEVQREVRNHMNNLPDLT-ALPDVTGGLAPLPSAGDLFN 380
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