4HTI,2QT7


Conserved Protein Domain Family
Receptor_IA-2
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pfam11548: Receptor_IA-2 
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Protein-tyrosine phosphatase receptor IA-2
IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism.
Links
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Statistics
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PSSM-Id: 463293
Aligned: 25 rows
Threshold Bit Score: 125.039
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4HTI_A          9 EARGYIVTDRDPLRPEEGRRLVEDVARLLQVPsSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLK 88   human
NP_001121431  485 EEYGYIVTNQKPLSLLSGAQLLETLAQRVHLStASFINISVVGSALTFRIRQNNQNLSLTDVADRAVALKSDLETETGVK 564 
Q60673        469 EEYGYIVTDQKPLSLVAGVRLLEILAEHVHMSsGSFINISVVGPAVTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQ 548  house mouse
XP_006636860  418 EEYGYIVTDQKPLSLFDGVRLLETLAERIHLTtSSFINISVVGPALTYRIRQNNHNLSAEDVADKAVAEKTFLESETGLK 497 
CAG09262      316 EEYGYIFTNKSPLSLYDGVKLLGLLADRIHLAtSSFINISVVGPALTFRIRQNEHNMTAAEVAAKAVSEKHFLESETGLK 395 
XP_015210361  568 EEYGYVVTDSEALTTDQGLHLMEVLARQVKLQmADFDDVDVLGPAVTFKVRSNPQNISTADVANIAVKQKISLEKEAGVK 647 
XP_023191229  488 DVFGYVITDTDRLQTDEGLHLMEILAHRANIQmTDFAELLVVGPAVTFKVSRNSQNVSTADVANVAVKQKADLEKETKLT 567 
XP_022534986  487 DLYGYIITDTDALPTDQGLHLMELVAHRAKIQmTDFLELSVVGPAVTFQVRPNSKNVTTTDVANVAVHQKTALEKEASIT 566 
EFN65526      493 LDYVYIIFEQEFHTWLEGGHVIAKVEELLGLPsGTLTDIRVGRAEVTFKVNQNDKNYNATDVANNIDTIRGKLQDALGIR 572 
2QT7_A          2 EEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSsGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQ 81  

4HTI_A         89 ILQTGVGSK 97   human
NP_001121431  565 IIQTGVGQR 573 
Q60673        549 ILQTGVGQR 557  house mouse
XP_006636860  498 ILQTGVGER 506 
CAG09262      396 IVQSGVGER 404 
XP_015210361  648 ILQAGHGDK 656 
XP_023191229  568 ILEAGVADG 576 
XP_022534986  567 IVEAGVTDR 575 
EFN65526      573 VIRAGIGNK 581 
2QT7_A         82 ILQTGVGQR 90
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