2HIX,4HTO,3GDE


Conserved Protein Domain Family
DNA_ligase_A_N
?
pfam04675: DNA_ligase_A_N 
Click on image for an interactive view with Cn3D
DNA ligase N terminus
This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I, and in Saccharomyces cerevisiae, this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation.
Links
?
Statistics
?
PSSM-Id: 461387
Aligned: 406 rows
Threshold Bit Score: 52.9609
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
2HIX_A         22 EFK-VIAEYFDKLEK--I-Ssr----------------------------lQLTALLADL----LsksD-----KTIIDK 60   Saccharolobus...
A0BMP6         17 TFR-WCSQVFDQIEKesRrKikislfqdalkqaqefkvkeefirftlcdvnSQSQLIEAAvpanV------------LYS 83   Paramecium te...
EFC36977       16 RFS-EFVALCKDIEEvsAhT-------------------------------EKSQVMKEF--------LsdfkgD--VYL 53  
EFA78161        7 SFF-SFYKLCKELENesShT-------------------------------GKSKIVALF--------VdkfdgD--LYL 44  
EGC32964        7 GSLySLSKLCEKLKEesThS-------------------------------GKTQIISSF--------CkvfngD--LYL 45  
XP_004359061   46 GSLkSMTGLCSVLEKesAhS-------------------------------GKMEVIQAF--------CeefkgD--LYL 84  
EGT55659      162 SFY-KFVKVCAVLKDtsNnT-------------------------------EKSAVITSL----Lq-kKgf-dgD--LKL 201 
XP_002646686  162 SFY-KFLKVCSVMKDisSsS-------------------------------EKSAVITSM----Lq-kKgf-dgD--LML 201 
XP_003113685  163 SFY-KFVKVCNVLKEisSkS-------------------------------EKSAAITSL----Lq-kKgf-dgD--LML 202 
Q95YE6          6 IFD-EVVDVFNKIRR--T-Snv----------------------------kSKQATFQKN----FeswKekcsdPSDMFV 49   Caenorhabditi...

2HIX_A         61 VVYIiqgkLWPDFL-GYpELGIGEKFLIKAISIATN-TDENsvenLyktIGDLGEV----ARRLKs---KQqstgilgfl 131  Saccharolobus...
A0BMP6         84 AIAQ--------------TYNLEFSLVERLYGEINS-------------MNNFEDVfnahKKS----------------- 119  Paramecium te...
EFC36977       54 LYKL----LFAKEn-QR-KFNLKDKKLVDVCASAFG-EDLDemidhmdsKGDVSET----LKKYLv---RSdha------ 113 
EFA78161       45 LAKL----LLVKEd-KR-VFRIKDKQMVKILAEVWN-EDLDemia-dldkGDVTET----AYKFYq---RQeni------ 103 
EGC32964       46 LAKL----LLCKEd-KR-VFRMRDKVMLKICAHIWD-ADLDdmia-dldnGDFTET----CKKFYieygKYp-------- 105 
XP_004359061   85 LAKL----FLVKEd-KR-VFRIKDKQMVKILAEIWD-ADLDdmta-dldkGDVTET----AKKFMi---KSgkf------ 143 
EGT55659      202 WLTF----LIRESd-ER-VYNVTDEQLIKNFARILD-TDEAkiqkyvdkSGDVALS----ISHAHe---KKvt------- 260 
XP_002646686  202 WLSF----LIRESd-KR-DYNVTDEKLVSYFVKILD-TDEAkilkyiskSNDVALS----IAHAHe---KKvt------- 260 
XP_003113685  203 WLTF----LIRESd-KR-NYNVSDETLIANFAKILD-MDQAkiqkyvnkSKDVAMS----ISHAHe---KKvt------- 261 
Q95YE6         50 IIRF----FVSDYErFR-KFDMGPTKLASFMAKTFHdVRADyvstIs---KDASTA----ARQLAe---KIseeyr---t 111  Caenorhabditi...

2HIX_A        132 gttsKESLTVDEVYSTLSKVAlttGEGSRdl----------kIRLLAGLLKK-ADPLEAKFLVRFVEGRLRVGIGDATVL 200  Saccharolobus...
A0BMP6        120 -------TSI-QFSSLFQKI-------QEifelsgggceeqkEVLVKDLLSLcSSAQEVKYLIRFLKKRMRIGLSTQSVS 184  Paramecium te...
EFC36977      114 --rdKGIVTLKQVDDFLEELT---QLSKKed----------qIRAFKKFVNDkLTGDELKFICRIICKDLKIRAGPKYLL 178 
EFA78161      104 --ptKSTLTLGQVDEFLDVLT---TISKFdd----------qVKAISKFLKK-CTAFDWRLVNRIIDSDLKINMGAKYFL 167 
EGC32964      106 ---eKSTLTLKQVDDFLDSLT---LSGKFde----------qVKIISSLLKK-CTPQDFRLICRIIDSDLKINTGAKFFL 168 
XP_004359061  144 --adQSTYTLKQVDEFLDKLT---TVSKFdd----------qVVVIKKFLKH-CTPNDWRLVNRMIDSDLKVNTGAKFFL 207 
EGT55659      261 --neKGKWSIQKVDRYLDKLS---KLEGEde----------vLNHLKFAAKR-MRHDELDVLIRLIRKELDTEASTATIL 324 
XP_002646686  261 --neKSNWSLQKVDRFLEKLE---TLKEDde----------iVKHLKFAAKR-FRHDELEVLIRLIRKELDTGATATVVL 324 
XP_003113685  262 --neKSNWSLQKVDRYLEKLE---KLEDEda----------iLSHLKFAAKR-FRHDELEVLIRLIRKELDTGADASVIL 325 
Q95YE6        112 endeSTVVTVSELNEILDFLAa--GPMDDgn----------kRDKMSKLVKR-CSEDELEWIFNVILKNVESALGAPSNR 178  Caenorhabditi...

2HIX_A        201 DAMA 204  Saccharolobus solfataricus
A0BMP6        185 QLLD 188  Paramecium tetraurelia
EFC36977      179 AALH 182 
EFA78161      168 EALH 171 
EGC32964      169 DALH 172 
XP_004359061  208 EALH 211 
EGT55659      325 KGVH 328 
XP_002646686  325 KGVH 328 
XP_003113685  326 KGVH 329 
Q95YE6        179 ILDW 182  Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap