3VYY,1WHQ


Conserved Protein Domain Family
DSRM_DHX9_rpt1

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cd19854: DSRM_DHX9_rpt1 
first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins
DHX9 (EC 3.6.4.13; also known as ATP-dependent RNA helicase A, DExH-box helicase 9 (DDX9), Leukophysin (LKP), nuclear DNA helicase II (NDH II), NDH2, or RNA helicase A) is a multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation, and RNA-mediated gene silencing. It contains two double-stranded RNA binding motifs (DSRMs) at the N-terminal region. This model corresponds to the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Statistics
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PSSM-Id: 380683
Aligned: 33 rows
Threshold Bit Score: 80.7787
Created: 23-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##  ##  #  #                   #                   ###  #             
3VYY_A          3 DVKNFLYAWCGKRKm-tPSYEIRAvgn-knrQKFMCEVQVEGy-nYTGMGNStNKKDAQSNAARDFVNYLVR 71   human
CBY43644      118 DIKGYLHIWCNQRRv-tPEFDYKElgn-rhkKLFSCSIQISGl-dFVAIKEArSKKEAQNEATWEYCNKLAE 186  Oikopleura dioica
CBY21964       38 EPKAWLYAWLGFRHi-rPTYSWQTmge-rpsQSFKCILSAEGf-kEKGTGTAqSKKEAQSQAAWNFIDWLLG 106  Oikopleura dioica
CBY14617      210 EIKGFLNIWCNQRRl-kPEYEFIErgk-ppkGTFICKLKIESf-dYIAECEArTKREAQADVAWDYALKLVS 278  Oikopleura dioica
XP_002164293    4 LAKGFLFHWVGKQMkliPHFYAVPdg----pHRFNYQAKIDGi-nYIAFGGGpSKKEGEAAAARDLLNYLVN 70   Hydra vulgaris
KPM10941        6 QTKAALNIWCSKKKl-kIEYLFVNeeeslrtHSFECEVRINTfdqVVGVGRGtNKKTASNEAALDSLRFLLK 76   Sarcoptes scabiei
XP_015791255    4 REKEELKSGLIKANl-pPAVYATNqmg--nqKRFMCRITVKNl-dYVGIGTAsNKEQAESTAARDLIAHLRY 71   two-spotted spider mite
XP_016660038    3 NPKAYLHEWCAKNNl-eLQFETKQagsnckpRLFICEVTVTGh-nYIGVGNStNKKLAQANASKDYLLYLTK 72   pea aphid
XP_022169398   26 KPYEMFMKWCSENNl-kPQYKITDik---qdENVKFEIRVPNy-tYIGVGNAkTEETARQNALKDILLYLAD 92   green peach aphid
XP_022202590  960 NPTAELKDWCMKNGl-tVKYEWLVln----rNEFLYQVKVPPh-eYIGTGNG-SNSVAKQRACQDFINHLPK 1024 brown planthopper

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