Class IA type III secretion system chaperone protein, similar to Pseudomonas syringae chaperone protein ShcA
This family includes type III secretion system (T3SS) chaperone proteins similar to Pseudomonas syringae ShcA and similar proteins. In P. syringae, which is a plant pathogen that can infect a wide range of species, the T3SS allows injection of the effector HopA1 (previously known as HopPsyA or HrmA), a protein that has unknown functions in the host cell but possesses close homologs that trigger the plant hypersensitive response in resistant strains. Chaperone ShcA binding to Hop1A shows that interactions in animal pathogens are preserved in the Gram-negative pathogens of plants.
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
Structure:4G6T: Pseudomonas syringae type III secretory system chaperone SchA binds the N terminus of effector protein HopA1; contacts at 4.0A - View structure with Cn3D
Jiyao W et al.(2023). "The conserved domain database in 2023.",