4N1D


Conserved Protein Domain Family
TGF_beta_NODAL

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cd13759: TGF_beta_NODAL 
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transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins
NODAL is essential for mesoderm formation and axial patterning during embryonic development.
Statistics
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PSSM-Id: 381637
Aligned: 17 rows
Threshold Bit Score: 187.128
Created: 16-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens BMP-3 (2QCQ) forms a homodimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # #   ## #         # ###                ##  ## ##  #     ##  # ##  #     
4N1D_A        13 SSCKRHPLYVDFnLIGWGSWIIYPKQYNAYRCEGECPNPVgeefHPTNHAYIQSLLKRYQPh-rVPSTCCVPTELSAISM 91  human
AAL99367     353 TPCKKVEFWVDFdHIGWGTWIIYPKRFNAFRCEGVCPTPVdqlyHPTSHAVMTSILNLHKPg-kAPMPCCIPTKLKALSM 431 Florida lancelet
NP_001072000 312 THCRKVSFEIDFeKIGWGSWIVYPKKYNAYRCEGQCRTPMrsdsKPTNHAYMQSIIATKRPdlhIPQPCCVPTKLKPLSI 391 Ciona intestinalis
NP_001091919 347 GPCRRIDMDVDFgRIGWDEWIIYPKQFNAYRCVGTCKGPLdsrdNPSNHAVMQDLVRLHQPerrTPEPCCVPTILRPLSM 426 purple urchin
ACB42422     291 VNCQLHNFEVDFnTIGWGQWIIHPKKYNAQFCFGVCPSPVdskyKPTNHAMLQTLMRLKRPn-vAPAPCCVPTRLNPLSM 369 bloodfluke planorb
NP_001161612 372 HPCRREGLTVDFdKIGWGSWIIHPKKFNAYQCVGSCPGPVdgdhNPNNHAIIQSMLNKSFPg-rVSGPCCVPTKLAPISM 450 Saccoglossus ko...
ELT90528      10 ESCQIKDLIVDFkVIGWSEWIVYPLSFNAYQCDGKCPLPVvqdyDPTNHAVLQSLMRIYDRd-sTTRPCCVPTKLKPLSM 88  Capitella teleta
XP_005991457 296 LLCQKVDFLVDFdHIGWGSWIVYPKRYNAYRCEGECPNPVgedfQPTNHAYMQGLLRYYHAd-hVPPLCCAPTKMSPLSM 374 coelacanth
XP_015277813 260 GLCHRVDFHVDFdRIGWGSWIVYPKQYNAFRCEGNCPVPLdegfQPTNSAYMQSLLKYFHPe-rVPASCCVPVRLRPLSL 338 Gekko japonicus
XP_013414870 271 SPCTKHDFYVDFsDIGWDQWIVFPKRFNAHFCYGQCRPHQshttPPSNHAIMQGLVSWVHPd-dVPMPCCVPTKLKPLSM 349 Lingula anatina
Feature 1                      ### #     #
4N1D_A        92 LYLDENekVVLKNYQDMVVEGCGCR 116 human
AAL99367     432 LYLEHGe-VVLRHHEDMIVDECGCQ 455 Florida lancelet
NP_001072000 392 LYYEDGe-VKQRDHEDMVVDECGCR 415 Ciona intestinalis
NP_001091919 427 LYFEEGa-VLVRHHENMIVEECGCR 450 purple urchin
ACB42422     370 MYYEFNe-LVVRHHEDMIATECGCR 393 bloodfluke planorb
NP_001161612 451 LYYEHGn-IVVKEHEDMIVEECGCR 474 Saccoglossus kowalevskii
ELT90528      89 LYYEKDm-IVVRHHEDMVVDRCGCR 112 Capitella teleta
XP_005991457 375 LYHEKGn-MLLRHHEDMIVEECGCQ 398 coelacanth
XP_015277813 339 LYYEEGr-LSIGHHEDMIVEECGCH 362 Gekko japonicus
XP_013414870 350 LYYEHDe-IVVRHHSDMVVDECGCR 373 Lingula anatina

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