2MEM


Conserved Protein Domain Family
SLED

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pfam12140: SLED 
SLED domain
The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.
Statistics
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PSSM-Id: 463469
Aligned: 37 rows
Threshold Bit Score: 101.895
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MEM_A          7 TVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNr-----------Gg-eVI 74  
XP_009914477  203 CPKIYFNHRCFSGPYLNKGRIAELPQSVGPGNCVLVLKEVLTLLINAAYKPSRVLRELQLDEeaa-------whGhgeTL 275 
RLW01976      225 CPQLYINHRCFSGPYLNKGRIAELPQSVGPGKCVLVLKEVLSMVINAAYKPGSVLRELQLVEdpq-------wnFqeeTL 297 
XP_011489602  532 CSKIFVNHRCFSGPYLNKGRIAELPQAVGPGKCTLVLKEMLSMLVNSAYKPGRVLKELQELEdqs-------wdCqeeTL 604 
EKC24670      816 CPKIYYNHKCFSGPYLSKGRIASLPKCVGPGPVGLVMKEVLTNLINVAYKSFRVLKELQLEGkpn-------pkMqqqTI 888 
ESN98778      466 CSKIYFNTTCYSGPYLHKSRLNVLPKSVGPGPVINVMITVLTKLIGCAYKSSRVLRELQLEGpak-------snMhhqVL 538 
EEC16391      496 CPCIFLNHRCFSGPFLSKGRLAELPRQIGPGPVALVLREVLSQIISVAYKSTRVLGELQLRGppd-------pkMqqqLL 568 
EFN86810      465 CPKIYFNYRCFTGPMISKGKLATLPKAVGPGPVVLVMREVLSMIVSVGYRSARILKVLQCDSkpd-------pgYhleVL 537 
XP_015790518  500 CPRIYFNHKCFTGPLLSKTKIRELPRFVGPGPVILVMQEVIAKIISVAYVPPRVLNEMSSRAfdellskhnivaTrtnNF 579 
XP_001635138    6 KFAVYINKSCSTGPLLDPNKVASLTTSY-HGTLPVVIKEVMESLINCSYNKKEAFKCLPQGN------------Gri-rI 71  
2MEM_A         75 TASFDGETHSIQLPPVNSASFALRFLENFCHSLQ-CDNLLSSQ 116 
XP_009914477  276 KAKYKGKSYRATVEVVRTADRVADFCRKTCIKLEcCPNLFGPQ 318 
RLW01976      298 KAKYRGKTYRATVKIVRTSDQVADFCRRVCAKLEcCPNLFSPV 340 
XP_011489602  605 KAKYKGKTYRSTIRTVRLAEQIPDFCQKVCLKLQcCPNLFSPA 647 
EKC24670      889 KAKYKGKSYRAVVEICRDINGLENFCRHICKKLEcCPNLISPH 931 
ESN98778      539 RTRYKMKNYSATVDICMRSNQIDSYCRDVCRRLLcCPNLISTH 581 
EEC16391      569 KAKYRGRTYRAVVETVRCSSQLEPFCRGVCAKLQcCPNLFGPR 611 
EFN86810      538 KAKHKNNTYRANVAIVTSGDMVADFCRNICKKLMvCPNLFGPL 580 
XP_015790518  580 KAKWQKKAFRDEIFVVTNNKDVADYCKIVCNHLKcCYHLFGPD 622 
XP_001635138   72 STCYEGKELGCFLRTVDRRAKFWQNIVEFLDELGcCENLVTEA 114 
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