Conserved Protein Domain Family
PBP2_Fbp_like_1

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cd13544: PBP2_Fbp_like_1 
Substrate binding domain of a putative ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily.
The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Statistics
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PSSM-Id: 270262
Aligned: 55 rows
Threshold Bit Score: 286.806
Created: 27-Mar-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to other members of the iron and thiamine transporter family.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
CAJ48801      28 TLTVYTAlEADQIKAYQAAFEREYPdIKIQWVRDsTGIITAKLLaeknnpKADVIWGLagTSLGLMDKegmlepyapkgl 107 Bordetella aviu...
YP_001815068  38 HLTAYVSaKEDIGRALLSSYCEVKK-CTYEFVRLsTEELVRRVTqeaehpRADIIIGGtwDAHQTLKKrglstpfpats- 115 Exiguobacterium...
ADO37795      31 RVVIYSClESFRNQDMIEQLQKDLPhISVNVQSLsTGKIASKLKaegtksEGDIIIGL--DTAYSESLkdyleplngydd 108 Eubacterium lim...
AEB77575      40 HLVVYSClRSEETQSILELFKEKTN-CSYEYIQLpTQEAVLRIEdemfnpKADIFLSGtcDSLNSLSKikaiksyksqnq 118 Clostridium bot...
NP_981668     41 HLVAYVAaREEVGEALLSSFCKPRG-CTYEFIRLsTEELLRRVEeeagnpKADIIIGGtvDAHQMMKQknlsipvtsqha 119 Bacillus cereus...
AEF84904      42 NLNVLVAyHESMVKTLAELFEAKTG-AKVSYLRMpTGEATAKLVaeadrpTVSVFMGGtvDAHENLKAknllasyvspee 120 Treponema primi...
NP_561149     40 HIVVYGSlREEEGKYLLEKFKNEYD-CTYEYIKLpTEEAVQRILdtkdnpQGDIFIGGscDGYEILKKydaleeynspwa 118 Clostridium per...
YP_877375     32 KLLVYVAfNEDEAKVLLEGFKEKTG-CDYSFLRFpTEEAAENVVreiqfqKADIFLGGtaDAIELLKNnncldkyvient 110 Clostridium nov...
AEE16731      33 ELFVYSViNDEETRLLTELFTERTG-IRVTYLRAaTGELVNRVIaerkspQADVLLGGpsSLHIAAAEkgalspyrspvs 111 Treponema brenn...
ZP_02950582   42 HIVVYVAsRDEVGSAILELFKEKTG-CTYEYLKMsTQESLSRIEserkdpKADIFLGGtcDVHVLMKKenlsekyiseny 120 Clostridium but...
Feature 1                                                                            ##          
CAJ48801     108 dqiapnmrdakpvpAWVGMDAFASAICFNTIeakkqnl----pvpkswqDLTRPEYAGKIVMPNpaSSGTGFLDVSAWLQ 183 Bordetella aviu...
YP_001815068 116 ----sqeglqdpdrYWIGYEVERLAIVVNTDlwkerigkn-ipypttlkDLTLEVYRDELILPDpnHSGTGATILQAIFD 190 Exiguobacterium...
ADO37795     109 --slyldefkipgrEYAIWERYGGCIVINEAllaekgl----peptcyeDLLKPEYKNLIVMPDpkSTGTGYLFLENMVN 182 Eubacterium lim...
AEB77575     119 --rnipmdfrlsngKWSAFEIHPFSIVINKEiwnkefktknislpknfkDLTNINFKGKIALPNplTSGTGHSFICYLYN 196 Clostridium bot...
NP_981668    120 --nrisktvkdkdgYWYGYEVEKLAIAINKErwneelaplglpypsrwqDLLNPVYKGKIVMPDpnVSGTAYTFFQSLID 197 Bacillus cereus...
AEF84904     121 --nfiptefrdsagVYKTQHLEVLSIGLNTErwkeefagkgipeptkleDLLNPLFKGEIIMPDptSSGTGYNFVDSVLA 198 Treponema primi...
NP_561149    119 --nnipakykdlrgYWTGFQITPLSIGINKSlwqthfgds-vpypkkieDLLNPEFKDKIILPNpqTSGTGYTLMASLYQ 195 Clostridium per...
YP_877375    111 --kkiseqyrdndgYWTGLYIEPLSIGINEErwnkefkd--lkkptkleDLLNPRFKGEIVLPDprTSGTGYTFLSYIVQ 186 Clostridium nov...
AEE16731     112 --asfpaytkdpagVWNGFCVLTLGIGINTDrfekkfpg--kklpavwdDLTDPDFKDEIVMTDpaSSSTAYLFVQNQLQ 187 Treponema brenn...
ZP_02950582  121 --dsipekykdregYWIGFEVSPLSIAINSDrwekefankgiampktyeDLLNPIYNGEIVIADpnTSGTAYTMLASIIQ 198 Clostridium but...
Feature 1                               ###                # ##                                  
CAJ48801     184 LfGEEKgwaYMDALHKNIGSYThSGSKPCNLAASGeFPIGVSFDYRAAKlkadGAPIEPIFPSEGlgWEVEATAIVKgtk 263 Bordetella aviu...
YP_001815068 191 GyGTSGd-tLLRQLIRQTRLFTaNGFAPVSYVASGeAMLGVNFIGDQQSl---REKYYPIKSIPLdtYSINAISKLKnrn 266 Exiguobacterium...
ADO37795     183 FmGEDEafdYLDQLVENIIFFTaSGSGPVNLLIQGeAAIGLGLTFTVVQeinnGMPFKIIYFGEGspYNTSSFAMLKdrd 262 Eubacterium lim...
AEB77575     197 SlGDKEfkrVVTKIKGNTGLLStRGYNVVQNVASGeYPIGVSYLNNIKLmeksTSDLIVITPNNTg-IDIHGVGIINkvk 275 Clostridium bot...
NP_981668    198 TvGEEEakeYVKNFAGQVGEVTvNGYMPVELVASGeYMIGINFMGDQRMlqkqGFPVVSIVPEQTg-LSVNAISKLKrap 276 Bacillus cereus...
AEF84904     199 YmGETRgwaFLEGLNKQVGQYTsSGYTPAEKTGLGeYLICINYLTDQVLvrnsGYPLKSIAYEGAg-WSMIPISVVAgse 277 Treponema primi...
NP_561149    196 ElGKEKfetFIAKLNDNVSSSTiSGFNSIQRVASGeYLITVNFLSDQLIanrsSDNIISIVPENAg-WNVDSIALIKnsk 274 Clostridium per...
YP_877375    187 SmGKDKgleFFKKLKNNVGQFTdSGFTPAKKVGLGeYLLTVDFINQQLIvknsGFKIESIVPKDAg-WTICPVAKIRnsq 265 Clostridium nov...
AEE16731     188 RlGYDAgweYLLKLSPLVGQFPsSGGAPPKLVGTGeYAIGIAYVHALAKykaqGFPVQIIAPPQSa-GEVDAVSVIKngp 266 Treponema brenn...
ZP_02950582  199 SmGEDKakeFLKKMKDNVGEFTtNGYTPVQKVATGeYLIGINFLSDQLLikdsGFNIVTNVPKDSg-WNIDAISKIKngp 277 Clostridium but...
Feature 1                                                                       
CAJ48801     264 npEAARKVADFSAS---RAANELYKANf--AVLAIPsvatsnpnlpsdlasrmIKNDFVWAAT 321 Bordetella avium 197N
YP_001815068 267 qqGLSNDFMRYVLS---EDGQDILRKVs--FGTPTYavsqvqpikksvgqdivSDYQDYLRRF 324 Exiguobacterium sibiricum 255-15
ADO37795     263 naEDVAAVFSYLYNhfiYRDKALFSPE---PVFKNQtitipnypqnivygdmkDINDIKHKEN 322 Eubacterium limosum KIST612
AEB77575     276 ntKASKAFVDFILS---DETQKKLQDFs--TSIPVKnyipyndk--yiipnleETTSLIELWK 331 Clostridium botulinum BKT015925
NP_981668    277 ngIIADLFIDYCLS---EEAGHILEKVs--FGVPTMfaknekeiegqpvrrtnQHISNSGIIE 334 Bacillus cereus ATCC 10987
AEF84904     278 ndPVTRQFIDFCLT---KEAIDAMVKVastLAVRTDanppdggiglkdipinrNYDPVEGAVH 337 Treponema primitia ZAS-2
NP_561149    275 heKIAKSFIDFVLS---KETSSDLSKFs--KAISTKnfdtnqfkiydkynfylAAEDREKIMQ 332 Clostridium perfringens str. 13
YP_877375    266 neKVANAFIEYCTS---KEAMEALREFs--MAIPTTndnadnkntelyklsstYNFNKAAKDR 323 Clostridium novyi NT
AEE16731     267 neANARAFIDFLLS---EEAQTLFASLs--YTTPVNpavasvpgavsiddvdlLPYDAELAGR 324 Treponema brennaborense DSM 12168
ZP_02950582  278 ngDIGKYFIDFCTT---KEVEETLNNIs--FAMLTRqdtrdiggiklnqldiyNDYNFVKASN 335 Clostridium butyricum 5521

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