Conserved Protein Domain Family
SCF

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pfam02404: SCF 
Stem cell factor
Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.
Statistics
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PSSM-Id: 396808
Aligned: 6 rows
Threshold Bit Score: 466.244
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q09108         1 MKKAQTWIITCFCLQLLLLNPLVKAQSSCGNPVTDDVNDIAKLVGNLPNDYLITLKYVPKMDSLPNHCWLHLMVPEFSRS 80  chicken
XP_007668267   1 MKKTQTWIITCIYLQLLLFIPLIRAQKNCGNPVTDDVKDITKLVGNLPNDYMIALKYVPEMDGLPNHCWLHLMVPELAKS 80 
XP_008109097   1 MKTAQTWIITCFYLQLLLLHPLVKTQSPCGNPVTDDVNDIAKLVGNLPNDYMIALKYVRKMDTLPNHCWLHLMVPELSKS 80 
XP_016281180   1 MKKTQTWIITCIYLQLLLFNPLVKTKGICGNPVTDDVKEITTLVANLPNDYMIPLKYVPDMELLPNHCWLHLMVPELARS 80 
P21581         1 MKKTQTWIITCIYLQLLLFNPLVKTQEICRNPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMVTHLSVS 80  Norway rat
XP_006084064   1 mkKTQTWIITCIYLQLLLFNHLVRTTGICTNRVTDDVKDVTKLVANLPKDYKIGLKYVPGMDVLPSHCWISKMVEQLSVS 80 
Q09108        81 LHNLLQKFSDISDMsdvLSNYSIINNLTRIINDLMACLAFDKNKDFIKENGHLYEEDRFIPENFFRLFNSTIEVYKEFa- 159 chicken
XP_007668267  81 LNNLLQKFSEISES---LSNYSIINNLTRIIDDLMACLASDKNKHFVQRNIHLYKKGSFIPKEFFGYFNRSIEAFRDF-- 155
XP_008109097  81 LSNLLNKFTEFSDMpdvLSNYSIINNLRRIINDLMECLSSTKYRNFRQHHDHLYEEGRFIPEEFFKHFSNTVESYKILa- 159
XP_016281180  81 LNNLLDKFSKISSS---LSNYSIIDKLIKIIDDLMGCLEE-KNKNFRKQNIHIYKRDSFNPEDFFRFFNKSIDAFKEYe- 155
P21581        81 LTTLLDKFSNISEG---LSNYSIIDKLGKIVDDLVACMEENAPKN-VKESLKKPETRNFTPEEFFSIFNRSIDAFKDFm- 155 Norway rat
XP_006084064  81 LTDLLDKFSNISEG---LSNYSIIDKLVKIVDDLVECMEEHALEN-VKKSSNSLELKMLTPEEFFRIFNRSINAFKDLem 156
Q09108       160 dSLDKNDCIMPSTVETPENDSRVAVTKTISFPPVAASSLRNDSigsntsSNSNKEALGFISSSSLQGISIALTSLLSLLI 239 chicken
XP_007668267 156 -QAEHSDCIFPTTTLMPEKDSRVSVTKPFLLPPVAASSLKNDS------TSSNREAFGYISSSSLQWISIAVPSIFSLVI 228
XP_008109097 160 kTPVQSDCVLPSTTETPPNDSRLSVTKSFLSYPFAASHLKNDSs----gNHNNEAALGFLGSPGMQGLSIALTSLVTLFI 235
XP_016281180 156 eTSEHSNCVLP-STIGPERDSRVNVTKPFLLPPVAASSLRNDS------SSSNRKAAGSTKDPSVQWVAIVLPSLFSLVL 228
P21581       156 vASDTSDCVLS-STLGPEKDSRVSVTKPFMLPPVAASSLRNDS------SSSNRKAAKSPEDPGLQWTAMALPALISLVI 228 Norway rat
XP_006084064 157 vSSKTSECVFS-STLSPGNDSRVSVTKPFMLPPVAANSLRNDS------SSSNRKALNSIGDSKLQWAAMTLPAFFSLLV 229
Q09108       240 GFILGAIYWKKTHPKSRPESnETIQCHgcQEENEISMLQQKEKEHLQV 287 chicken
XP_007668267 229 GFILGAIYWKKKHPKHSVEV-ENIQGN--EEDNEISMLQERERELQEV 273
XP_008109097 236 GFILGAVCWKKTARKHILESnPTTQANicQEDNEISMLQQKDKSLLQV 283
XP_016281180 229 GFVLGALYWKKKQMNLKMEV-ENIETS--EEDNEISMLQENDGEFQEV 273
P21581       229 GFAFGALYWKKKQSSLTRAV-ENIQIN--EEDNEISMLQQKEREFQEV 273 Norway rat
XP_006084064 230 GFGFGALYWKKKQPNLTRAV-ENIQIN--EEDNEISMLQEKEREFQEV 274
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