1PPT,1QBF,1RON,1FVN,1BBA


Conserved Protein Domain Family
PAH
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cd00126: PAH 
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Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with amidated C-terminal ends; receptor binding and activation functions may reside in the N- and C-termini respectively; occurs in neurons, intestinal endocrine cells, and pancreas; exist as monomers and dimers
Links
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Statistics
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PSSM-Id: 238072
Aligned: 17 rows
Threshold Bit Score: 42.2563
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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receptordimerization
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site
Evidence:
  • Comment:arginines are required for receptor binding
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #   #  #   ### ##
1PPT_A     1 GPSQPTYPGDDAP--VEDLIRFYDNLQQYLNVVTRHRY 36  turkey
1RON       1 YPSKPDNPGEDAP--AEDMARYYSALRHYINLITRQRY 36  human
1FVN_A     1 XPSKPDNPGEDAP--AEDLARYYSALRHYINLAXRQRY 36  pig
130790     1 YPPKPETPGSNAS--PEDWASYQAAVRHYVNLITRQRY 36  anglerfish
P48098    28 FPPKPDNPGDNAS--PEQMARYKAAVRHYINLITRQRY 63  European river lamprey
P80024     1 MPPKPDNPSPDAS--PEELSKYMLAVRNYINLITRQRY 36  sea lamprey
321015    26 MLAPPPRPEEFTS--AQQLRQYLAALNEYYSIMGRPRF 61  California sea hare
CAB63265  25 MLTPPQRPEEFKN--PNELRKYLKALNEYYAIVGRPRF 60  great pond snail
730169     4 MLSPPERPREFRH--PNELRQYLKELNEYYAIMGRTRF 39  brown garden snail
1171754    2 DKDFIVNPSDLVLdnKAALRDYLRQINEYFAIIGRPRF 39  sheep tapeworm

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