Conserved Protein Domain Family
A-2_8-polyST

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pfam07388: A-2_8-polyST 
Alpha-2,8-polysialyltransferase (POLYST)
This family contains the bacterial enzyme alpha-2,8-polysialyltransferase (EC:2.4.99.-) (approximately 500 residues long). This catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA).
Statistics
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PSSM-Id: 429439
Aligned: 22 rows
Threshold Bit Score: 126.509
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_034632117       2 NLFIVSNLGQLIQAQNVIKQNDlidnvlv------vlwtkrnTVVRDNI---------INNVDN-------Q------FF 53  Alkalihalob...
CDF82554           2 SLFIIGSPWHAALANAIIEREE--------------------IKNPSII---------VEEISS-------S------SL 39 
WP_068400361       1 MLIIVGSPWQALLAKSYILKEN--------------------ITDPQYL---------IEKSSP-------K------SF 38  Pedobacter ...
EDM34775           1 MLIIVGSPWQALLAKSYILKEK--------------------IEHPQYV---------IEKSSP-------K------SY 38 
jgi:Nos7524_1914   4 RFAFVNGIWQLCMVVAAFEQER--------------------LHHPHTIykdylvvysLASANTelmdfveKnsykfwNW 63 
PSB20038           4 RLVFVNGIWQLCMVAAAFLQER--------------------AKHPEVKyqdylvlysRKTANTklvefvkTicdafwNW 63 
WP_044664276      26 FIASSTSHWHALGIDAEINSNEelkqsggiifisphpkdgflIDSNDFI---------CSRSPK---------------- 80  Syntrophace...
CDC04958          24 VVAFCITPWHSVGIEVALEKLNslekqlnghlfickhpktglALSPTSVnlssygnfkTEIYNIpaasplkK------LF 97 
RAR47242           3 YIFTVHSPITFLMCISIVRHEKlllndvii----itsdyklpIQVGKVV--------------SgfaeqnkS------LF 58 
KKK38900           3 ILYLCFTPYHI-KVSNYLSKTEyksdenhmil-------------------------------------sscsginenTL 44 
WP_034632117      54 SNVDTL-QLPNFPNKF-------HVNN------LMKIRKDYNHLIENY------PFTDVFVCN---YNSHYNFLYDIAKA 110 Alkalihalob...
CDF82554          40 EQILGIlKHPTLAIFQhentrfeSIKKlgifrfIRNMHLEFERIENSCkylnqsQTRKVYYFNfysPITRKIIKSLPKAL 119
WP_068400361      39 AEIIKIlDADENSIRMiiewsklSVLSka---kANIASDYIDAIIQTL---------------------------KQDYF 88  Pedobacter ...
EDM34775          39 AEIIKIlNVGEADIRItiewgrlSVLSfd---kAKKASAYIDEILTNL---------------------------KEEYF 88 
jgi:Nos7524_1914  64 QGVIQVkWVTSEWDRNlnkeqnsAVQEivkhfdLDSPDAVEEIWLCKI--------------------QFRDERFFADIF 123
PSB20038          64 DGVIQVdWTTADWNPQqnkadhlPVQQilqsfhLNSPATVDEVWLCKI--------------------QFRDERLCADIF 123
WP_044664276      81 IKIAMVnPIQTRPHELirltiklIINKiknktnTFYLLSPMTPKLLSL---------------------RLFTETFLVNS 139 Syntrophace...
CDC04958          98 DHIYHFfHIIKSPNFSadkpscyVISP---------LNPDYKTISDAM---------------------------KLRPD 141
RAR47242          59 KKIKSVnAVKSFDKYVyqitegdDFTA------FIDIMHNYQKLLVTN-------------------------------K 101
KKK38900          45 KKFVKItQYKTLNYTDielslreGVKLga--syFKKYKSSIEHFIKTIke---qEYDKIVYFSdnpIAYQLLFNDIKQNS 119
WP_034632117     111 KNININIF------------------------EEGLGTYkfkvvldkmqennkikfierftiaqnfaikdfkqaikqtdl 166 Alkalihalob...
CDF82554         120 SKREVIRV------------------------EDGICDY----------------------------------------- 134
WP_068400361      89 KTVETILVfseqtvlfkiiynlfgasktyiksEDGILDYlpglkhhsl-------------------------------- 136 Pedobacter ...
EDM34775          89 QKVETVLVfseqtvffkifydvfgdtktylksEDGILDYlsklkhhgv-------------------------------- 136
jgi:Nos7524_1914 124 SQAKIVMY------------------------EDGLHTYla--------------------------------------- 140
PSB20038         124 SKAAIVIY------------------------EDGLHTYap--------------------------------------- 140
WP_044664276     140 CQLNYILI------------------------DEGIGTYlsssiwkrvqkddksnydifgniiiqlkngifrvfnsfiiy 195 Syntrophace...
CDC04958         142 ENIIAVVV------------------------DEGLggrs---------------------------------------- 157
RAR47242         102 RCKLFHFF------------------------EEGTDSYmk--------------------------------------- 118
KKK38900         120 VNTKLMFV------------------------EEGTGIYlknyrypfr-------------------------------- 143
WP_034632117     167 fkwlvflllfiknnlfnplfillkgmarICLSFFPIefVnkikkiktPKEL-------R-------------SFDGTIPM 226 Alkalihalob...
CDF82554         135 ----------------------------FEFNFINHkkPllliknilATLLiksdlyrR-------------RNSKLENK 173
WP_068400361     137 -----------------------------------------------------------------lkqiagylFIRSKVK 151 Pedobacter ...
EDM34775         137 -----------------------------------------------------------------tkkiagylLMGAKTK 151
jgi:Nos7524_1914 141 --------------------------nnYLISLPQVnwIhprealarYKKFvrevishEvdwyhkgikrshlRRIVKFYS 194
PSB20038         141 --------------------------tsYLIHSPPIdwSnlrktlsgYKHLfgevishRidwqhegvkrshlRRIKKVYS 194
WP_044664276         --------------------------------------------------------------------------------     Syntrophace...
CDC04958         158 ---------------------------------------------------------------------rfsWFISRIHD 168
RAR47242         119 ---------------------------pLHLEDFTRtaIsssfrdykFKSLa------N-------------EIIRCLRG 152
KKK38900         144 -------------------ykiliflakILFNNNNIrvFmhgkggfeDEVLlr--------------------------- 177
WP_034632117     227 FDKAYFTFP--------DQGSELfka---kqyNE---LKLDYQLKKEVEyylkns-----------qtlslLDRKSVIFL 281 Alkalihalob...
CDF82554         174 TSSYYCFFP--------EKITQRwkskklialLE---YATEIRKNFSITee------------------aiVDDSESLII 224
WP_068400361     152 YYIYKNYYPvfsqvimfSRVEAV-----------------SEERYVPLTilrqellsvlktayqitegadtFKGKDVLLL 214 Pedobacter ...
EDM34775         152 YYVYKSYFPifrkvimfRKMTEV-----------------SGDQYVPLTslkkefltvlkeayalggaevgFKDKDVLLI 214
jgi:Nos7524_1914 195 VLGTQIPIPavfrnirvEYVNKNi-------lQK---LFAELNHRFDCQlype---------------vthhHTKTALLI 249
PSB20038         195 VLGTQIPIPstlqkvpiEFVEPDl-------lRS---FFVDLNHRLQCEsrla---------------dtpsNSKTALLL 249
WP_044664276     196 -------------------------------kcisvenrflfnnvknnlrvnatvrdnynklllananqypLQGPVALFV 244 Syntrophace...
CDC04958         169 GINPLKSFItflqeitlDKISYSqlvkkgcliDQtlfVKKHGNFFVQNKlaekyrsiletrnladdkqnfsIYENAIIIN 248
RAR47242         153 FTSQVHSLPyhsqsyqyNLLRKY---------YS---LSNYCFPGVLETqktkispnfsneeitilcadyrL-NESILLI 219
KKK38900         178 ---------------epELIESKgkkiklskde-----------------------------freilinndCTENFVLEK 213
WP_034632117     282 DQVYn-----VPPEKHTEIIMKylneFYPQR--NIFIKMHPRSKTevrks-fedkiKK-----YNNIRLIe-lDVEMPFE 347 Alkalihalob...
CDF82554         225 GQTLfed-giATLEQEVRLYKT----ASDTLpgPVKLKAHPRTTR-----------LKrdairAAGIEIL---ETKFPAE 285
WP_068400361     215 CQSLsed-kvIPLHEELKLYEKfi-qRCNDLklTVIIKPHPRSCPekiea-lskltSSqveffE---------DYGIPAE 282 Pedobacter ...
EDM34775         215 TQSLsed-kvMSLEEEMKLYEKfi-qRCNDLnlSVIIKPHPRSYPekiqa-lttltSQhvqffE---------DYGIPAE 282
jgi:Nos7524_1914 250 GSNFchl-dyFPRESEVAVFAHvi-qKLTAQgyKIFWKEHPRNQIplfee-fkqiiTL------DNFVYLe-gEQKIPIE 319
PSB20038         250 GSNLshl-qsFPREREVEVFADti-rRLNEQgyTILWKEHPRNQKplfed-iqeivEL------DNFVYLs-nEQKLPIE 319
WP_044664276     245 TNPYsey-nyVDVIDEYNNIVKkivqLLIKNgfKVIIKPHPREDPnkyqk-linknNN------GNIKIL---NKNKPIE 313 Syntrophace...
CDC04958         249 TQPFeet-gqLQNNADIYSLKKii-qSLQNCgeKVIIKPHPREKNldrykdlgctiEK---------------RKGIAQE 311
RAR47242         220 DETYpdv-ylIDDIEYKNIVLAtlhkLNYRHdnCVFIKLRPSSReqnsr--lvrllKDl----SIHFEIL---PSEIVAE 289
KKK38900         214 GSLFcpsfiiNDPKVRNKAFNEif-lCYYQKreFLYVKLHPSEREvdslqklvesyDG---------YIIilnRDDLTSE 283
WP_034632117     348 AILVE--KKPKTIVSLTSTSLVYGPKLISGTEVVSCA 382 Alkalihalobacillus okhensis
CDF82554         286 NLIAT--RPYHSIVGMWSNTVIYSAPLFHIRSFTMNH 320
WP_068400361     283 SMLLN--GKFKEVVGVYSNTIIYAHQFFGVKGISLLT 317 Pedobacter cryoconitis
EDM34775         283 SMLLS--GKFKEVVGIYSNTIIYANEFFGVKGISLLT 317
jgi:Nos7524_1914 320 VIVSQ--NKIDLCVSTVSSSLFYLNYIYGIKTLTCAR 354
PSB20038         320 VIVAE--SNIDLCGSTLSSSLFYMKQIFGIKTVTCVR 354
WP_044664276     314 KEIVL--IKPSVIVGFMSTALLTAKVIFNIPAFTAVK 348 Syntrophaceticus schinkii
CDC04958         312 EILSTlkTKPKAVIGFCSTTLVTAKIFWDIPTYSCIH 348
RAR47242         290 GLFLS--SKNLKVIGFVSSLLFYAS-IFGHQSYSLLY 323
KKK38900         284 DIIVN--PNIKEVISDVSSSLINAYYLRDDIKIISYQ 318
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