4IRX,4RXM


Conserved Protein Domain Family
PBP1_ABC_IbpA-like
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cd19968: PBP1_ABC_IbpA-like 
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periplasmic sugar-binding protein IbpA of an ABC transporter and similar proteins
The periplasmic binding protein (PBP) IbpA mediates the uptake of myo-inositol by an ABC transporter that consists of the PBP IbpA, the transmembrane permease IatP, and the ABC IatA. IbpA shares homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge.
Links
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Statistics
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PSSM-Id: 380623
Aligned: 8 rows
Threshold Bit Score: 360.549
Created: 28-Nov-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4IRX; Caulobacter crescentus sugar-binding protein IbpA bound to myo-inositol, contacts at 4A
  • Structure:4RXM; Mannheimia haemolytica sugar-binding protein IbpA bound to myo-inositol, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #                                                                   
4IRX_A     10 EVVVSFNDLSQPFFVAXRRELEDEAAKl-GVKVQVLDaqnnsSKQISDLQAAAVqGAKVVIVAPTDSKALAGAADDLVEQ 88  Caulobacter cresce...
SCX73786   34 PVAVLFHNMAEPFFVFMNRELLDEARKl-KVKVNVVDgqassPKQSADVSNALTqGVSGIVIAPTDAKAMVPAINEILSE 112 Variovorax sp. EL159
OLE62749   27 KIGMTVPGLKFPFFVTMKNDAEKAAAKl-GATIVFADaqndsSKQAADVENFVAqGVQAILISPMTVDSLVPAIEAAVKA 105 Deltaproteobacteri...
KPW57349   31 KILINFQTLSIPYFIYMHEQASQEAKAl-NVKLLVQDaqsssTKQSSDVENALTqGVDAMVVAPNDVTALAPALNEVLSE 109 Pseudomonas syring...
BAM01570   30 RIAFSVPAMSFPFFVHMEKQVRDEAARigNIEIITLDgqdstTKQVADLEGVIAkGYDGLIVSPRTSEGVAPVIQQVIDA 109 Caldilinea aerophi...
4RXM_A      6 LVVFSLPNLSSPFEVQLQKVAVETSKKl-EIKLQVLDgqsssTKQASDLENAITrGAKGIIISPNDVNAISGAVEEIIKE 84  Mannheimia haemoly...
OGO81925   53 TVGFVAFNMAFTWMQYAAERVKKSAADa-GIKLVVYDanndaAKQTSLIEDLIAqKVDGIITSPIDVKSMVPALEAADKA 131 Clostridiales bact...
KPJ88646   16 VIGFDAFNVSMTWMKFAHDAMVEEAKNl-GVKLIVLDseneaSKQASNMEDLVAmGVDGIVANPIDVDSLSPAINAAAEK 94  Spirochaetes bacte...

Feature 1            ##                                         ##    #   #                   
4IRX_A     89 GVAVISVDRniaggktAVPHVGADNvaGGRAXADWVVktypagARVVVITNDPGssSSIERVKGVHDGlaaggpaFKIVT 168 Caulobacter cresce...
SCX73786  113 NIPVVTVDRrvdgakkPIPHVGADNvaGGRKMAQWVVqnfpegARIVFLTGQPGssSAIDRAKGIHEAlaaagpkYKIVA 192 Variovorax sp. EL159
OLE62749  106 GIPVATVDRkan-tdaVLVHVGADNvqGGRAAAKFIIdklgnkGSVIELEGTPGasAATDRKAGFDEVikk--snVKLLV 182 Deltaproteobacteri...
KPW57349  110 KVPLVTVDRrvegtdaPVPYVTADSvaGGRLMAELVTsnmkngARVAFIGGTPGssTAIDRAKGVHDGlkaggekFQLVA 189 Pseudomonas syring...
BAM01570  110 GIPVVTIDRraegvtgLLAHVGADNvlGGEEQGKALVklfpdgAKIFELLGTPGasPAIDRSKGLHNIidp-vgnIEVVC 188 Caldilinea aerophi...
4RXM_A     85 KIPAATLDRkve-sskPVPHFGANNytGGQEVAKAVKakypngAKIILLTGQPGstSNIERTKGIRDElaaggdkYKIVV 163 Mannheimia haemoly...
OGO81925  132 GIPVVTFDRrad-gapYFAFVGSDDrlGGSMIAAYIAqklngkGNVVEIVGQLGagPTIDRGEGFHEEiak-sadIKVVF 209 Clostridiales bact...
KPJ88646   95 DVAVATFDRaai-gadYVFYVGCDDveGGRLVADFVAdklggrGKIILLTGTPGssPARDRTKGFFERlek-ypgLEVVF 172 Spirochaetes bacte...

Feature 1          #                          ##                          #                   
4IRX_A    169 EQTANSKRDQALTVTQNILTsxrdtppdVILCLNDDXAXGALEAVRAAgldsakVKVIGFDAipEALARIkaGEXVATVE 248 Caulobacter cresce...
SCX73786  193 EQTANWARDQGLTVTQNILTsltgnppqVIISANDDMALGAVEAIQSAglgkqgIKVLGYDAspDALKKVrdGEMAATVE 272 Variovorax sp. EL159
OLE62749  183 SQTANFGRSEGQNVMESLIQkyp--kfdAVFGANDEMIIGAVEAMSAAgi--knKVTIGFDAtpDAFQYMkeGKLNATID 258 Deltaproteobacteri...
KPW57349  190 EQSGEWERAKAMSVAENILTslsanppdAIICASGDMALGAAEAVRAMglk-gkVKVIGFDAypEVLRAIrdGDIAGIVE 268 Pseudomonas syring...
BAM01570  189 QQTGNFNRDGGLTVTENCLSsnp--dvqAIVAANDDMALGAAEAARAAgi---sVPIIGFDAlpEALQAIasGDLYGSVE 263 Caldilinea aerophi...
4RXM_A    164 DQTGNWLRSEGLRIIESVLPtlke-kpeVIISANDDMALGAIEALRSQglkagdILVTGFDStpEALARVkdGWLYLTAD 242 Mannheimia haemoly...
OGO81925  210 SQSGKFEREAGMRVMEDAINavgkdqinAVFAHNDDMMMGAIQAMKDAgmdlskVITISYDGvpDSLKAIkaGEHEATLQ 289 Clostridiales bact...
KPJ88646  173 NQTGEFWREKGMQVMEDAITvtkg-dfdAVVCQNDDMMMGAIQAILTAgidvkdVVITGYDGvpDGLRAVrdGQADCTVQ 251 Spirochaetes bacte...

Feature 1     #                                    
4IRX_A    249 QNpGLQIRTALRQAVdkiks--gaalKSVSLKPVLIT 283 Caulobacter crescentus CB15
SCX73786  273 QSpGRQIRTALQVLVanirn--kteiKTVAIEPILIT 307 Variovorax sp. EL159
OLE62749  259 QFpGKQAGDALKYLVdyvnd--kkkpAKQVVYINPAP 293 Deltaproteobacteria bacterium 13_1_20CM_2_69_21
KPW57349  269 QSpSKQIRTALRMAVkkvrg--eaelETVIVQPFMVT 303 Pseudomonas syringae pv. berberidis
BAM01570  264 QFpGGQSRTALQIIMdfltkgekpanDVVLLAPKLIT 300 Caldilinea aerophila DSM 14535 = NBRC 104270
4RXM_A    243 QRpSFAVSTALEQVVgnire--skevSGADYPPKIIL 277 Mannheimia haemolytica PHL213
OGO81925  290 YP-VGMAGAAATILInylkd--gtkpEKVNDKIDPWI 323 Clostridiales bacterium GWC2_40_7
KPJ88646  252 YP-IGQAPEVLRRLVaylkg-eapaqKDYEMPPWVIT 286 Spirochaetes bacterium DG_61

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