4RY8,3L49,4WT7


Conserved Protein Domain Family
PBP1_methylthioribose_binding-like

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cd06305: PBP1_methylthioribose_binding-like 
Click on image for an interactive view with Cn3D
similar to methylthioribose-binding protein of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily
Proteins similar to methylthioribose-binding protein of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes transition from an open to a closed conformational state upon ligand binding. The sugar-binding domain of the periplasmic proteins in this group is also homologous to the ligand-binding domain of eukaryotic receptors such as metabotropic glutamate receptor (mGluR), DNA-binding transcriptional repressors such as LacI and GalR.
Statistics
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PSSM-Id: 380528
Aligned: 20 rows
Threshold Bit Score: 273.402
Created: 25-Oct-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:4RY8; Pseudothermotoga lettingae sugar-binding protein binds 5-methylthioribose, contacts at 4A
  • Structure:4WT7; Agrobacterium vitis sugar-binding protein binds Allitol, a rare alcohol monosaccharide sweetener; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##                                                 #                
4RY8_A     17 RIALVRevgeGSFFERYLAGAQSMAre-lGVTLLEATahGDMARMVTMIENFITqRVDAIIIDHGrpd-plmPKIKEALD 94  Thermotoga letting...
3L49_A      7 TIGITAigtdHDWDLKAYQAQIAEIer-lGGTAIALDagRNDQTQVSQIQTLIAqKPDAIIEQLGnld-vlnPWLQKIND 84  Rhodobacter sphaer...
4WT7_A     34 RIGISTagtdHFFDLQAYNAQIAEVkr-lGGEPLAVDagRSDGKLVAQLQTLIAqKPDAIVQLLGtlt-vidPWLKRARD 111 Agrobacterium viti...
NP_744901  36 RIAVSMtgtsHYFDIKAFQAQVNEIkr-lGGTPITLDagRNDRNLVTQLHTVVTqKPDAVIQTLGtls-vidPWLKRIQA 113 Pseudomonas putida...
CAH38494   53 RIGITAagtdHYWDLQAYQGAVDEVkr-lGGTPIALDagRNDSRQIVQIQTLIAqQPDAIIEQLGtas-vlePWLRKIRQ 130 Burkholderia pseud...
EPZ52644   46 HIAVVSlydnDEWSAQFLSGIKAAAqaypDVTLTETQasYNQAEMVSQLQAVIAqHPDVIIVNHAsqpsalaPAVQQAIN 125 Alicyclobacillus a...
KGQ11456   34 TIGVAVvgtqHFWDREAYKGATEEVek-lGGKVIGVDggRDNQVHANNHDILLSrKVDAVISILGdsa--vePKFKALRD 110 Beauveria bassiana...
KMZ52910   60 TIGVAVlgtdHEFDLHAYQGQIDRIke-lGGEAVAVDgeRNDQKHIADIENMITqKPDAIIKQLGdad-vyePVMKKISD 137 Dorea sp. D27
KSU51958   31 TIGVAVvgtqHFWDREAFQGAVDEVek-lGGTVLTTDgnRDNTLHAQNHDIFLAqNVDAVITILGdas--vdPKLQQLHD 107 Microbacterium sp....
OOB80114   53 SIAVIRnlpsDDHTTQFLAGAVSEGna-lGYTVDTFIsnGDDARFQELVAQQIEkGYDGLIISHGkae-ystQMLEPALA 130 Epulopiscium sp. N...
Feature 1             #                #                                 # #   #              
4RY8_A     95 rGIRVVTFDlvvdd----nrvpEIEQDDLLIGYLISKQLAvdf-agnANVIYVNVGg--FAPLDKRDKMWQIIKWRfpgi 167 Thermotoga letting...
3L49_A     85 aGIPLFTVDtatp-----hainNTTSNNYSIGAELALQMVadl-ggkGNVLVFNGFy-sVPVCKIRYDQMKYVLEAfpdv 157 Rhodobacter sphaer...
4WT7_A    112 aGIPVLTIDvgss-----hslnNSTSDNWGIGKDLALQLVsdi-ggeGNVVVFNGFy-gVTPCAIRYDQLVNVIKYfpkv 184 Agrobacterium viti...
NP_744901 114 aGIPLFTIDvpsq-----yslnNTTSDNVAAGRALAEQLVrdt-ggkGRILVFNGFy-gVPVCAIRYDELKKVLADhpql 186 Pseudomonas putida...
CAH38494  131 aGIPLFTIDtasp-----sslnVVTSDNFAIGSQLALKLVndi-rgeGNVLVFNGFy-gVPVCAIRYDQLKAVLKWypkv 203 Burkholderia pseud...
EPZ52644  126 qGIKVISVEadipv----kgvaHANENNQQLATLSLNALAqgi-hnrGNIAVIWVGg--FTPMVQREVSLKAFEKAhpdi 198 Alicyclobacillus a...
KGQ11456  111 aGIPVFTVDhvsq-----ysvnNTTSDNYTLGSTIGRYMAdal-ggkGNVAVFNAFsnsLRICGIRYDQWKYVLKDypdi 184 Beauveria bassiana...
KMZ52910  138 aGIPLFTVDlvsq-----ysicNSTSDNYLIGEELARNMFedl-ggeGKIAVFNGFy-gVRVCGIRYDMMKYVAKDypgi 210 Dorea sp. D27
KSU51958  108 aGIPVFGVDhase-----wavnNAQSDNEVGGTALGKITGdal-ggeGSIAVFNAFgssLSFCGERYDAWKNELATnypn 181 Microbacterium sp....
OOB80114  131 kGMEIVAFDtafadniipdgitSTAQDDEALAKLSLDEIIantenspARILKIWYGp-gVPPLDSRQVIYKEYEDAglie 209 Epulopiscium sp. N...
Feature 1                                               # #                         #         
4RY8_A    168 ---kevAKIGAVTGstaADTQTRMEAAMKEKPea---nAVLAM-WDEFAKGAVRAIMQAGKsdqFKVYSVDVTTEDIQMM 240 Thermotoga letting...
3L49_A    158 --kiiePELRDVIPntiQSAYSNVTDMLTKYPnegdvgAIWAC-WDVPMIGATQALQAAGRt-dIRTYGVDGSPEFVEMV 233 Rhodobacter sphaer...
4WT7_A    185 --kiiqPELRDVIPntvQDAFAQVTAILNKYPekgsikAIWSA-WDIPQLGATQALAAAGRt-eIKTYGVDGSPEVLQLV 260 Agrobacterium viti...
NP_744901 187 --qivqPELRDVIPntvQDARSQIAALLNKYPkgd-iaAIWSA-WDIPQLGASQALIDAGRs-eIRTYGVDGTPEVLELL 261 Pseudomonas putida...
CAH38494  204 --kiiePELRDVIPntaQNAYAQISQLLQKYPkgt-isAIWAA-WDIPQVGATQAVDAAGRr-eIRTYAVDGSPEAVALV 278 Burkholderia pseud...
EPZ52644  199 ---hviATYGDASNttiSDTMARTEALLRQYPnagqlsAIWAS-WDQFAIGAVKAEQALQRn--VPIYGIDVSNQDLALM 272 Alicyclobacillus a...
KGQ11456  185 --kiiqPELAEQFAnspEDARKKTLELLSQYPkgk-ldAIHVAcWDQPAIGIVQALEETGRdkdVKVTAIDAGPETLEIM 261 Beauveria bassiana...
KMZ52910  211 --efiePELQDVITgaaEDARKKTLDLLTKEPdv---dAIWLA-WDTPCIGVAQACAEAGRe-eVKIYAVDGSSTVLELV 283 Dorea sp. D27
KSU51958  182 i-kliePELAEQFAnapDDARQQTLALLEKYPvgt-iqDIHVAcWDQPAIGVVQAIEDSGRt-dVKVTAFDAGPDTLEIM 258 Microbacterium sp....
OOB80114  210 tlewigPSTLDNVQ---GEVADRVAAVLPKYPagt-vdAMWGS-WDEMAKGGYSALKEAGRt-dINLVSIDVSNQDINLM 283 Epulopiscium sp. N...
Feature 1                                                    
4RY8_A    241 iqqnsPWVATVGTDSYAVGRLAVRAAAAlVGGEKLP-KYLLVEPQLI 286 Thermotoga lettingae TMO
3L49_A    234 adpesPAGAVAAQQPSEIGKLAVQNVARhLAGQEVK-PFTFAPAVLI 279 Rhodobacter sphaeroides 2.4.1
4WT7_A    261 adpasPAAADVAQQPAELGRQAIQNVAL-LLSGKTLpRESYVPALLA 306 Agrobacterium vitis S4
NP_744901 262 ahddsPIGAVVAQQPDLIGRTAVRNVARyLAGQRDLpKETHVAALLT 308 Pseudomonas putida KT2440
CAH38494  279 rnptsSAAAVVAQQPALIGRTAVRNVARyLAGDRSLpAYTFVPSVLV 325 Burkholderia pseudomallei K96243
EPZ52644  273 kqsnsPWKATAANDVYQYGTAMVNYALRdAYGESIPsSIWIPGALIE 319 Alicyclobacillus acidoterrestris ATCC 49025
KGQ11456  262 aekdsPLVANVAQQPHLIGQTSAENVARyFAGQKLP-IQTFIPVIPV 307 Beauveria bassiana D1-5
KMZ52910  284 adqnsTMYGDMAQNPYQIGQAAVDQCARyLAGEQVPsTVYSAPVYVN 330 Dorea sp. D27
KSU51958  259 sepgsPFVGNIAQLPRKIATISADNVGKyFLGEEVE-KVSYVDTIPV 304 Microbacterium sp. NIO-02
OOB80114  284 meegsVWTATAAVDPHMIGTVSARILVNkLIGEPTPeTYNFEAQIIR 330 Epulopiscium sp. Nuni2H_MBin003

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