6MJE


Conserved Protein Domain Family
Csm1

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pfam12539: Csm1 
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Chromosome segregation protein Csm1/Pcs1
Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis. Csm1 also plays a mitotic role in DNA replication. This family also contains the Schizosaccharomyces pombe homolog to Csm1, Pcs1. Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together. The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment.
Statistics
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PSSM-Id: 432621
Aligned: 66 rows
Threshold Bit Score: 83.3266
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6MJE_C        23 EIIKDLFEHLCGVRVHRTYEDDTGLWFDTSQGSKN-------GI----MDYKLGFVKsqaenTTEVd-TEVIYVPL---- 86  [Candida] glabrata
EAZ62977     215 GFTLDMLELLTGLRIVNFEEDESKYFFDVKQSGSN-------GQdeiyINYQLVISK-----SFATt-AEINYIPTflea 281
EGW33657     178 SITLDMIELLAGVRVVNFQEDDSMLYFDVKQSSPP-------LF----ITYQLIISK-----EFEAt-AQVNYVPTflda 240
EMG49204     114 SFTLDMIELLTGVKVINFENNSTEYVFDIRQTSSTnq----gLT----MNYQLVLPS--------EknPQISYVPTflda 177
EER32159     157 SLTLDMIELLTGVKVVNFENTEDEYIFDIKQSSMK-------QEl--vVHYQLVLST------IPN--SEINYFPTflda 219
XP_719422    114 CFTLDMIELLTGVKVINFENTSDEYIFDIKQSSSVks----gLT----MHYQLVLASqp--------sPEINYIPTflda 177
XP_001523381 135 CFTLDLLELLTGIKVTNFEESPTRYTFDIKQTSSN-------KEl--fIEYLLILSK------VDS--SQINYVPTfled 197
EEQ39330     259 GVTLDMLELLTGVRIISYEEDRVKFYFDVKQSSTNsdsdndaIS----VTYRLVIKR-----KFENt-AEVTYVPTffqk 328
XP_013937359 238 gTKLEITELLTGLTCQEYIEDSENMIFKMKQQGET-------CF----LIYQLLISK--------TgaGEIVYIPI---- 294
CAY67837     222 QIIFDMFELMTGVSCTDFEETNEQIVFTMRQSSVD-------STf---LMYKLSINK-----TTSRhiGEIEYHPI---- 282
6MJE_C        87 LK------QRTAEELQel-----qKKLPDYLFETLSFPLR 115 [Candida] glabrata
EAZ62977     282 LEn-----DDEDQEQVdnan-llkEILPDYLCENLSFPYD 315
EGW33657     241 LEnef-dhGDDEVDIVenar-flkRILPDYLCEKLLFPID 278
EMG49204     178 LD------GEEEEEIAnak--alkKKLSDFLCENLTFPFD 209
EER32159     220 LE------GDEVEEYEntk--rlqKVLPEYLCENLSFPFD 251
XP_719422    178 LE------GEEVEDYEnak--ilqKILPDYLCENLSFPFD 209
XP_001523381 198 DGtrdsayKANQKNLV--------KVLPDYLCEYLSFPFN 229
EEQ39330     329 MDes---pASEEEEIMnsharvlaPHLPEYLKDSLIFPYN 365
XP_013937359 295 LKheesqsGSERKEWTenln-kleKVLPDYLLDNLTFPSN 333
CAY67837     283 FS------EQLQQDFEsv-----kSRLPDYLKDDLTFPYN 311
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