1SVY,1J72,2FGH


Conserved Protein Domain Family
gelsolin_S2_like

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cd11289: gelsolin_S2_like 
Click on image for an interactive view with Cn3D
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins.
Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.
Statistics
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PSSM-Id: 200445
Aligned: 26 rows
Threshold Bit Score: 105.397
Created: 27-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative type 2
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: putative type 2 Ca binding site [ion binding site], 2 residue positions
Conserved feature residue pattern:D [DE]Click to see conserved feature residue pattern help
Evidence:
  • Comment:Activated actin-bound gelsolin has eight Ca2+-binding sites: six type-2 sites, one in each sub-domain, and two type 1 sites, associated with the first and the fourth sub-domain.
  • Comment:not all members of this subfamily may bind calcium at this site
  • Structure:1SVY: the second sub-domain of Dictyostelium discoideum severin binds Ca2+ in a type 2 binding site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #                     #                            
1SVY_A         12 KPRLLHISGD-KNAKVAEVPLATSSLNSGDCFLLDAGLTIYQFNGSKSSPQEKNKAAEVARAIDAERk--GLPKVEVFXE 88   Dictyostelium...
O15195        134 IQRLLHIKGR-KHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRErggGRAQIGVVDD 212  human
Q07171        191 ETRLFQVKGK-RNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDh-nGRARVQIVDD 268  fruit fly
Q27319        131 PARLFHVKGR-RNIRIRQVEVGVGSMNKGDCFILDCGSQVYAYMGPSSRKMDRLKAIQAANPVRADDh-aGKAKVIVIDE 208  American lobster
O81644        136 ETRLYTCKGK-RAIRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEVVQYLKDKYh-eGTCDVAIVDD 213  thale cress
O61270        135 RKVLTRVKGK-RPVRATQVPIKWTSLTDSDSYVFDIGKEIYVWSGPKASHFEKNKAIQYADGLKNERq--GRAELHHIDS 211  Halocynthia r...
Q8WQ85       1026 QKILIQVKGK-RKIRVRMVKLSTSSLNCHNSFILDAGPRIFVWAGSKTSRVNKAKALDFANRIRTKEr-gGKSTLIQLDQ 1103 Dictyostelium...
A8XV95        134 KPHLFHCKGK-RNVRCTEVECEVGSLNLGDVFILDLGKDIYIWMPPDSGRLERVKGMARAKNIADVEr-mGASKVHILDD 211  Caenorhabditi...
O96923         61 DAKLIQVTGKdEPFHFISVPMSVEFLNLEDVFIMQSDAYIFVWCSEQANIKKKAKAVQMAQKLKVEIg--CQRAVQVLEI 138  Dictyostelium...
NP_001090765 1000 KLMLVQIKGR-RHVQSRLVEPRASSLNSGDCFLLITPHHCFLWVGEFANVIEKAKASELASIIQTKRe-lGCRASYVQTV 1077 western clawe...
Feature 1                          
1SVY_A         89 TDs---dIPAEFWKLLG 102  Dictyostelium discoideum
O15195        213 EAka-pdLMQIMEAVLG 228  human
Q07171        269 FStd--aDKQHFFDVLG 283  fruit fly
Q27319        209 TAs----GSEAGESSPG 221  American lobster
O81644        214 GKldtesDSGAFWVLFG 230  thale cress
O61270        212 LDd---kESRTMLKDFF 225  Halocynthia roretzi
Q8WQ85       1104 GRd---eQSFDFWEILG 1117 Dictyostelium discoideum
A8XV95        212 EWd----NDPTFWSYFG 224  Caenorhabditis briggsae
O96923        139 GE-----EHPTFLFCLG 150  Dictyostelium discoideum AX4
NP_001090765 1078 EEgi--nTHTHGAKDFW 1092 western clawed frog

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