1IM5


Conserved Protein Domain Family
nicotinamidase
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cd01011: nicotinamidase 
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Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).
Links
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Statistics
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PSSM-Id: 238493
Aligned: 29 rows
Threshold Bit Score: 215.976
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic triadmetal bindingconserved
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                                                        
1IM5_A      3 EEALIVVDMQRDFMPg--GALPVPEGDKIIPKVNEYIRKfkekgaLIVATRDWHPe---nHISFrer------------- 64  Pyrococcus horikoshii
NP_627144   2 RRALIVVDVQNDFCEg--GSLAVSGGADVAAAITELIGQapagyrHVVATRDHHVa---pGGHFadnpd----------- 65  Streptomyces coeli...
NP_787820  20 TSALLVVDIQKDFCEd--GALAVLGGNALAKRISCFLSErqldyaLKIASRDWHApnssnNGHFsenpd----------- 86  Tropheryma whipple...
NP_738995   8 SRALILVDVQKDFCPg--GTLATARGDEVAGLLGAFQLShpqdfdAVVATQDWHId---pGSHFsdspd----------- 71  Corynebacterium ef...
EAA39121    1 MAALLIIDMQIDFCKg--GALGINDGAEVIPFINQLRQSrh--ydMVVITQDWHPp---hHCSFasrynkqpf------- 66  Giardia lamblia AT...
BAB88836    1 MRGLLVVDVQNDFCEg--GALGVDGGARVASGITEHIAAhgseyaVVVASRDWHDaendnGGHFardgea---------- 68  Heterocapsa circul...
XP_324893  34 RPALLVVDMQEDFCPp-nGTLAVTGGRSITPLINTLLSSpl--fvLRIATKDWHPp---nHISFasnhnhasspspccpd 107 Neurospora crassa
NP_696074   2 TKALIVVDVQPTFCEs--GELGVAGGNAVAERIADYVNAhrseyaYIATTQDWHIe---pGAHWsaepd----------- 65  Bifidobacterium lo...
NP_472045   2 KIAAFDIDSQKGFTPlcpDELPVSGGDKIVPELNFMASLa----tLRIGSKDAHPk----NAVWvvdskdemla------ 67  Listeria innocua
NP_253605   6 KIASFDVDAQKGFTPlcpDELPVPGGDAIGGALNQLASRa----aLRLGSKDAHSp----KAAWvvesaeqmlr------ 71  Pseudomonas aerugi...

Feature 1                                                                  #                  
1IM5_A     65 --------------------------ggpWPRHCVQNTPGAEFVVDLp------EDAVIISKatepdkeAYSGFeg---- 108 Pyrococcus horikoshii
NP_627144  66 -------------------------yvhsWPAHCVAGTEGVGFHPNFapavasgAIDAVFDKgay--aaAYSGFegade- 117 Streptomyces coeli...
NP_787820  87 -------------------------fsnsWPIHCVANTPGSAYHDDLpv----dLFDKHIYKgfg--saAYSAFegfdk- 134 Tropheryma whipple...
NP_738995  72 -------------------------fvdsWPVHCVADSDGAAMHEKIht----dRIDEFFRKgqy--saAYSGFegtav- 119 Corynebacterium ef...
EAA39121   67 --------------------tpygdhdylWPDHCVQDTPGAQLHPDLvv----eKTDVRIRKgtkvdldAYSCFgg---- 118 Giardia lamblia AT...
BAB88836   69 -----------------------pnfvtsWPVHCVAGTTGAEYHPELtl----pDHTIHVRKgqg--mpSYSMFeghsd- 118 Heterocapsa circul...
XP_324893 108 ssgkaaipflstttvhnphnpsesyttrlWPSHCIADTPGASLIPELdv----sKIDQILEKgtnrlveMYSAFydpfts 183 Neurospora crassa
NP_696074  66 -------------------------fvdtWPKHGAAGTLNAELHPAIka----lNIEHHFKKgqy--saAYSGFegiedn 114 Bifidobacterium lo...
NP_472045  68 -------------------eleypnadrtWVRHCEPGTKGFELLDGLpv---vtDYDYFIWKgmepdihPYGACyhdive 125 Listeria innocua
NP_253605  72 -------------------playpdadltWVSHCVPGTPGFELLDELpr---piDYDFFVWKgvepdlhPYGACyhdlae 129 Pseudomonas aerugi...

Feature 1                                              #                                      
1IM5_A    109 -----------------tdLAKILrgnGVKRVYICGVATEYCVRATALDALKHGFEVYLLRDAVKGIkpedEERALEEMK 171 Pyrococcus horikoshii
NP_627144 118 ---------------ngtgLAEWLrsrEIDEVDVVGIATDHCVRATALDAAREGFRTQVLLDLTAGVaaetTERALEELR 182 Streptomyces coeli...
NP_787820 135 ---------------kgvpLEEILa--GIQQIDIAGIATDYCVYKTAVDSIKNGFITRVLLDLCVEInkerSEACIVQLQ 197 Tropheryma whipple...
NP_738995 120 --------------sddtpLVDWLharGITDVDIAGIATDHCVKATTLDALKAGFRVRVLTGFCAAVdtktGDRALEEMH 185 Corynebacterium ef...
EAA39121  119 -----------------tkLAQFLrehHIKTCDIVGLAFDFCVRYSAIDARREGFEVRVFREGSRPVdkdaVDIVIKELT 181 Giardia lamblia AT...
BAB88836  119 ---------------dghtVEVILtnaGVTEVDVVGIATDHCVRASALDAKAAGFSVRVINDLVAAVspdtERTARGEMT 183 Heterocapsa circul...
XP_324893 184 p------------rvsdsgLAHMLreaKVTHVYVVGLAADYCVWSTAMDAHNEGFETVVVEEATKPVdedgWRRCKEALV 251 Neurospora crassa
NP_696074 115 tdriqtreeveaeqsagktLANALkaaGVSRVDVVGIAESHCVKDTALDAKKLGFEVTVFEDLTVPVseelGVAARKQMA 194 Bifidobacterium lo...
NP_472045 126 --------------qlstgVLEYLreqQVDLVLVGGLAFDFCVKTTVIQLSRAGFSVLVYLPATRALseqgFDETKEQLA 191 Listeria innocua
NP_253605 130 --------------rrstgVIEYLrqnGVSHVLVGGLALDYCVKNTALQLRRAGFEVLLYLPACRAIaedtAQRACDEMR 195 Pseudomonas aerugi...

Feature 1             
1IM5_A    172 SR-GIKIV 178 Pyrococcus horikoshii
NP_627144 183 EA-GVELS 189 Streptomyces coelicolor A3(2)
NP_787820 198 DL-GVHIV 204 Tropheryma whipplei str. Twist
NP_738995 186 TA-GAELL 192 Corynebacterium efficiens YS-314
EAA39121  182 EL-GVRVE 188 Giardia lamblia ATCC 50803
BAB88836  184 EA-GVVFA 190 Heterocapsa circularisquama virus
XP_324893 252 GEpGVRVV 259 Neurospora crassa
NP_696074 195 AG-GITLA 201 Bifidobacterium longum NCC2705
NP_472045 192 NTeKVQLI 199 Listeria innocua
NP_253605 196 DA-GVILC 202 Pseudomonas aeruginosa PAO1

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