4X9U,4PMK,6TI2,6FPG,6TI2


Conserved Protein Domain Family
DPBB_kiwellin-like

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cd22270: DPBB_kiwellin-like 
Click on image for an interactive view with Cn3D
double-psi beta-barrel fold of the kiwellin family
Kiwellin (KWL) proteins comprise a widespread family of plant-defense proteins that target pathogenic bacterial/fungal effectors that down-regulate plant defense responses. They are part of a spatio-temporally coordinated, plant-wide defense response comprising KWL proteins with overlapping activities. Zea mays KWL1 specifically inhibits the enzymatic activity of the secreted chorismate mutase Cmu1, a virulence-promoting effector of the smut fungus Ustilago maydis. KWL proteins adopt a double-psi beta-barrel (DPBB) fold, which provides a versatile scaffold that can specifically counteract pathogen effectors such as Cmu1.
Statistics
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PSSM-Id: 439250
Aligned: 36 rows
Threshold Bit Score: 134.347
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative effector binding site [polypeptide binding site]
Evidence:
  • Comment:based on the specific binding/inhibition of Zea mays KWL1 to fungus Ustilago maydis virulence-promoting effector Cmu1
  • Structure:6TI2: Zea mays KWL1-b binds Ustilago maydis chorismate mutase 1; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # #                                       ######                       ## #   
4X9U_A        61 HPTYDCSPPVt-------------sSTPAKLTNNDFSEggddggPSECDESYHNn-NERIVALSTGWYn---gGSRCGKM 123 Actinidia delic...
6TI2_A        65 YPQYRCSPPVt-------------aSTRAVLTLNSFEKgkdgggPSECDNAYHSd-QEKVVALSTGWFs---nMARCGHR 127 Zea mays
XP_002467037  13 VLLLQCAVAQq-------------aGTPAVMALTSFEDg----dPTACDGQYPSn-DDLVVALSTVWFk---dATMCHRK 71  sorghum
CDM80607      18 FLQVSCAVSRhpaesk----felrqNVPAVMTVNGFQQgeggggPASCDGQFHSd-DEFVVSLSSEWYa---gGARCGRY 89  bread wheat
Q7XD65        22 LEMPSCAVARrhhhdhhdkpghhdgGFPAVMTVNGFEKgedgggPAACDGHYHSd-GELIVALSTEWFa---gGRRCHRR 97  Japanese rice
KAE8803995    17 LQAVSCAVARhhadql----tpltgVQSGTMTLDGYEEgeegggPAACDGIYHSd-GDFLLTLPTELYa---gGALCHRF 88  Hordeum vulgare
XP_002467038  18 QASWWCGANG---------------DTPAVMTVTSFENdgngggPAACDGTYHSn-GEPLVALPTALYa---gGSRCGKQ 78  sorghum
XP_024515302  52 YYLYDCSPPVsr-----------rrPNPAILYYIELDN------GSRCEEKKYQp-SDLVASMATGWYnyqrpGGACGRN 113 Selaginella moe...
XP_024515347  49 YRFYACSPPLq-------------iVNRAVLYSTTFNE------NLSCTDQIFSi-QDQVVSLSSGWIqr--nFSICLTN 106 Selaginella moe...
XP_024528945  94 YQFFNCSPQEq-------------pRNFAAFYFIELEEs-----PTSCNRSTPPrnSELLASMSTGWFa---nGSSCHRE 152 Selaginella moe...
Feature 1                                 ## #                                              
4X9U_A       124 IRITAs---------NGKSVSAKVVDECDSrhgcdkehagqppcrNNIVDGSNAVWSALGLDk-nVGVVDITWSM 188 Actinidia deliciosa
6TI2_A       128 IKISAa---------NGNSVYAKVVDECDSvhgcddehnfeppcdNNIVDASPAVWDALGLDq-nVGMVDITWSE 192 Zea mays
XP_002467037  72 IRITNsl-------pNGLNLVAEVVDECDTqsg----------ckDNMIATSKRVWKALGLDt-nLGEVPVTWSI 128 sorghum
CDM80607      90 IRIVDs---------FNIGINVKVVDECAGc--------------DNEVGASSHIWKSLNLDt-sQGEVNIRWSD 140 bread wheat
Q7XD65        98 IRITPsehgrrggggGRRAVEATVVDECDSrrg----------ckDDVVDSSPAVWRALGLDt-dSGEVRVTWSD 161 Japanese rice
KAE8803995    89 MNIASt--------eTGRSARAMVVDLCDDc-------------gDDELGTSAAVWIALGLHt-dAGVAPITWSV 141 Hordeum vulgare
XP_002467038  79 IRITSt--------qSGIYMMAKVVDECDAds-----------ckDNMISTSKFVWDVLEVDt-yIGEVPITWSD 133 sorghum
XP_024515302 114 VTITAl---------NGRTVTAMVVDECTAmagctaatsfyppcsPKSLGATQGVWEALGYKi-sEGIIDITWEF 178 Selaginella moellend...
XP_024515347 107 INITAp---------NNRSVVAKIVDECSSkagctagtaywepcaPNAIAGTPGVWSALGYDpgdGILRDVSWSK 172 Selaginella moellend...
XP_024528945 153 IVITAe---------NGLSVTATVIDQCGSnigctadtgfygpcsPRSLGGTRAVWEALGQTy-fDNVLAVTWSW 217 Selaginella moellend...

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