Conserved Protein Domain Family
Peptidase_M60

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pfam13402: Peptidase_M60 
Peptidase M60, enhancin and enhancin-like
This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.
Statistics
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PSSM-Id: 433178
Aligned: 24 rows
Threshold Bit Score: 224.181
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Amuc_2001  252 GKVNGVF-VGGVSKNSDWKKMLENSPTEVV-DIVGSRVHLVY-PVEELKQFCPDK-GEELIALYDRIIGMEQQIMGLYKY 327 
Q5E705        1197 SAIAAPMfMMTSATEGSWITTPEESDAPIT-EIVGKRFSYTT-TTAGIKGHSEVD-VLEMTKQFDLFTIGVNEFYGRDGV 1273 Aliivibrio f...
jgi:Amuc_1514  369 GAVPSPLfVMGKTTPEQWAEQLENTKAPWG-EIRMPRLIVTM-PVEQLKQCPD---VQKTAEFLQKNMALQDWIMGWDTK 443 
Q815S7          98 GGSHFPLfILGKHTKKDWDEMLKKYKDLYAvELKGERSLITT-TYDSVQKYMKNTdPTDLMKLHDKIIRLENAVAGLSED 176  Bacillus cer...
Q2U0W8         367 TAEPFPLfREGSTTDAQWKSMLDVTKVPFA-EHDGKRVIITGlAKHAKKYADNGQrQQELLDTYAHIIAIQDRFSALKYN 445  Aspergillus ...
Q87UG7         341 GAIPMPYyVSGATAQLQWLLMLLLTEAPEV-ELVGARIVVAA-LKETALKFSSIG-AQAVMRSHEEVMRLEAEVSGLDGS 417  Pseudomonas ...
Q5LB88         529 GQVNGYFdVAKHQ-ASDWNKLLSNAVDKYF-DVVGHYAHLTF-PTERFRTHTPD--GKALIDAYDQIVNSEMELMGLYKY 603  Bacteroides ...
CCZ86632       201 GKVNGYFdAETQT-NEDWNKLLDQAVSPVM-DVKTRYMQLAY-PVEFLKKFDYGK-GKELAQAYDQIMTQQYEFCGALKY 276 
EFC44438       475 QVVKTPFfKDGIHTDQEWNSTIRNYPGPWV-EIESEHFAFNVqATPTARQLSE---VSTVAKYWGNVVAMYYELSQR--- 547 
Q9Y4C2         633 GAVHAPYyKLGETTLEEWKRRIQENPGPWG-ELATDNIILTV-PTANLRTLEN---PEPLLRLWDEVMQAVARLGAEP-- 705  human
jgi:Amuc_2001  328 RMlp-------kNRMFGRVIWN---------------G-FMHADGT--GAAFh--NGTMKEVGNPDRIpg-saWGIAHEF 379 
Q5E705        1274 SGahkmftdsapELEYQNMRLVddiq--------isiG-SAHSGYPvmSTSF---PRQKSSLFKATDN-----WMLGHEI 1336 Aliivibrio f...
jgi:Amuc_1514  444 P-----------DRLHHPMRFVvdrq--------isaG-AGHSGYP--AMAT----KDWTNSIATGSIihsgsWGLWHEL 497 
Q815S7         177 SVgv-------aKSPTHYVQFVekrk--------lakGdFMFAKHY--HTGYi--PTAMNRVLDIEVLek-dgWGPWHEV 236  Bacillus cer...
Q2U0W8         446 ARdp-------rDRPSL-LRPMvves--------vnsG-VATATNY--RAAIp--NRLSDQIYWVPRLrn--sWMVFHEL 502  Aspergillus ...
Q87UG7         418 A-----------PIHTRPALLIyavegsgtanphattGcIVLP-----HTDYi--SQYNEALLGGLAAe---rWVTLHEY 476  Pseudomonas ...
Q5LB88         604 NKlf-------kNRMYLHVMYTs----------------YMYATSY--HTAYn--DGTLAELCNVDKLktsacWGPAHEI 656  Bacteroides ...
CCZ86632       277 NRvp-------eKRILARVNFN---------------Y-FMFRDGD--GVAFlgnESTMKSALGPDIYk---dWGVNHEI 328 
EFC44438       548 ------------QTRDYKERMQadiq--------isaG-YMHSGLS--FYDF-----SRSERWNYSSRr----WGHYHEL 595 
Q9Y4C2         706 ------------FPLRLPQRIVadvq--------isvG-WMHAGYP--IMCH---LESVQELINEKLIrtkglWGPVHEL 759  human
jgi:Amuc_2001  380 GHVNQvrPAMKWVS-TGEVTNNIYSAYVNYMLNPSS-MRLEHERINGGDGN-MIGGRFNAYLNNgilkgenwlvqsgpdk 456 
Q5E705        1337 GHNQA--ANWLNVVgAGETANNVLALYTQERNTGDMpRIKVSITNATEWANgDHPWADGTNADR---------------- 1398 Aliivibrio f...
jgi:Amuc_1514  498 GHNHQs-PPFTMEG-QTEVSVNIFSMVCEVMGTGKD--------FESCWGGgMGPYGMSAEMKKyfsgtqty-------- 559 
Q815S7         237 GHLHQq-EPWKWSK-VREVTVNIYSLAVQKAL-----------------GNqLEMDEHYKNSFEylekpkae-------- 289  Bacillus cer...
Q2U0W8         503 GHQRQitRTWSWRA-MTEVTVNIYSLANLREYKP----------------PgHKNVAEWDNAKQyltkaskekd------ 559  Aspergillus ...
Q87UG7         477 GHHYQ--TSYNSYGpFGEVTVNLYALAVSLHY-----INEYTYVFPDRWSGtVNWLALPRTAKTygap------------ 537  Pseudomonas ...
Q5LB88         657 GHCNQtrPGLKWLG-TTEVTNNIMSEYIQTTIFGQPsRLQTEDMGDGSRN------RYSKAWTQiiaagaphgn------ 723  Bacteroides ...
CCZ86632       329 GHVMQmsPQLTWGG-MTEVSNNLFTMYVATLAGQPSrLSKSK--------------NYDKAFKEvleaekkpfi------ 387 
EFC44438       596 GHNFQe-GAWTYDQ-SGEVTCNIFSLYLEEHYPDSAnTYGKGFNPPRGLETtYKGNTQPFKGDWts-------------- 659 
Q9Y4C2         760 GRNQQr-QEWEFPPhTTEATCNLWCVYVHETVLGI---------PRSRANIaLWPPVREKRVRIylskgpnv-------- 821  human
jgi:Amuc_2001  457 rsggdnrpmvhdhfvkLAPLWQLELYFkva--------------------------gkgNPDFYPDIFYKAIKMDTRGKK 510 
Q5E705        1399 ----------------LNFFGQLKLWAednfdiaqweseaklaeersiynkneagqydqGWNFYKYLHRAARMPETFTEG 1462 Aliivibrio f...
jgi:Amuc_1514  560 --------neapnkvqLFFWVELMYYL--------------------------------GFDAFRQVALQFHDKPYDNGE 599 
Q815S7         290 --------rfiddinpLTMFWQLNVVY--------------------------------GEHFYPRLHQAYRLLPQSEMP 329  Bacillus cer...
Q2U0W8         560 -------fdsagfylsLVMFEQLRVVF--------------------------------GDGFYHELHRDARHTLVVD-- 598  Aspergillus ...
Q87UG7         538 ------------esdpLAMLEQLRKGL--------------------------------GEGFMPAWHRYIRENPGEAP- 572  Pseudomonas ...
Q5LB88         724 ------fgsdsdvfckLVPFWQLELYFgkvlgrt-------------------plqqsdKGGFYPDVYEYIRTHDNLRTA 778  Bacteroides ...
CCZ86632       388 -------mcvgdpfqkLVPFWQLYLYAke----------------------------kgYNDFYADLMEYMRNHPHKGTG 432 
EFC44438       660 --------------agLLFYLDLIQAF--------------------------------GWVAIRKTFVDYQKNGPQPQN 693 
Q9Y4C2         822 --------knwnawtaLETYLQLQEAF--------------------------------GWEPFIRLFTEYRNQTNLPTE 861  human
jgi:Amuc_2001  511 DGE-----------------LQLAFMKNACDAARQDLTDFFRKTG 538 
Q5E705        1463 LNKgdvnycssefaqvnslsKQDMMMICSSFLTGKDIETFFIKWK 1507 Aliivibrio fischeri ES114
jgi:Amuc_1514  600 LSDe---------------kKWEWVMNAFSKVTGKNMGPFFKIWR 629 
Q815S7         330 HSDe---------------eKKQLFIYMTSKVAGQNLIPFFEEWG 359  Bacillus cereus ATCC 14579
Q2U0W8         599 -KDa---------------dKKHHFMTKAAQLTGQDLTEYFTKWG 627  Aspergillus oryzae
Q87UG7         573 --------------------GLKYFVLSACIAAKRNLTEFFADWG 597  Pseudomonas syringae pv. tomato
Q5LB88         779 -GE-----------------QQTEFVYICSLIAKANLLDFFTKWG 805  Bacteroides fragilis NCTC 9343
CCZ86632       433 NASi---------------hNMYEFAKVSCDLLKTDLTDFFQAWG 462 
EFC44438       694 DDQ-----------------KRDQWMTRFSKVVGRNLGPFCDAWS 721 
Q9Y4C2         862 NVD-----------------KMNLWVKMFSHQVQKNLAPFFEAWA 889  human
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