1MDZ,2OGA,3BN1,1O61,2C7T,1B9I


Conserved Protein Domain Family
AHBA_syn
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cd00616: AHBA_syn 
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3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
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Statistics
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PSSM-Id: 99740
Aligned: 87 rows
Threshold Bit Score: 284.048
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1MDZ; catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1MDZ_A     22 ELAAVKTVLDsgwi-----ttgPKNQELEAAFCRLTG-NQYAVAVs-sATAGMHIALMALGig--eGDEVITPSMTWVST 92  Salmonella typhimu...
AAB84075   34 FFARLEWALNnnwl----tnggPLVREFEGRVADLAG-VRHCVATc-nATVALQLVLRASDv----SGEVVMPSMTFAAT 103 Saccharopolyspora ...
AAO39694   18 FIPYLEIIWQnkqf----tnngPMHQKLEKKLCEFLG-VEYISLFn-nGTIALITAVQALGv----KGEVITTPYSFVAT 87  Escherichia coli
NP_811797  15 SLEELNVYLQdiwqrkwitnngYYHQMLEAALCEYLG-VPYISLFt-nGTLPLTAALLAMRi----TGEVITTPFSFVAT 88  Bacteroides thetai...
NP_348966  15 YSDYVRKIFNsgiv----tnngEMVRKLKKSLEEYLG-VKNIVLVq-nGTLALQIAYKILNl----KKDIVTTPFSFVAT 84  Clostridium acetob...
NP_718741  15 LNSYLERVHDtgwy----tnfgPLHNELTEKLEEYLG-VSNLLLVs-nGTLAIQLAAKVFN-----VKQTITTPFSFVAT 83  Shewanella oneiden...
Q50723     51 LAEDFVQIAQanwy----tnfgPNERRFARALRDYLG-PHLHVATlanGTLALLAALHVSFgagtrDRYLLMPSFTFVGV 125 Mycobacterium tube...
NP_831714  17 YLDELKEIDTshiy----tnygPINQRFEETIMSSFFqNRGAVTTvanATLGLMAAIQLKKrr--kGKYALMPSFTFPAT 90  Bacillus cereus AT...
NP_713777  19 WIEKVKVLSKnasf-----iggEEVSTLEKNLTSYTE-TKFSIACa-nGTDALQLALRALGvg--kGDSVILPDSTFWAT 89  Leptospira interro...
NP_214183  14 EKKALTEILEskri-----trdGWTDTFQEAFAEFLN-VKYCATVc-sGTVALFIGLKALGir--nGEKVVIPAMSFMAT 84  Aquifex aeolicus VF5

Feature 1                                                                                     
1MDZ_A     93 LNMIVllGANPVMVDVDrdTLMVTPEHIEaai---tpqTKAIIPVHYAGAPADLDaiyal-geryGIPVIEDAAHATGts 168 Salmonella typhimu...
AAB84075  104 AHAASwlGLEPVFCDVDpeTGLLDPEHVAslv---tprTGAIIGVHLWGRPAPVEaleki-aaehQVKLFFDAAHALGct 179 Saccharopolyspora ...
AAO39694   88 AHSLVlnGLKPVFVDIDskTLNIDPRRIEeai---tpeTQAIMPVHCYGNPCDTQaiadi-aqkyNLKVIYDAAHAFGve 163 Escherichia coli
NP_811797  89 THSLWlnGIKPVFVDIDpvTCNLDPDKIEvai---tpnTTAIMPVHVYGYPCDTKsiqqi-adkyGLKVIYDAAHAFGve 164 Bacteroides thetai...
NP_348966  85 TSSQVweGLNPVFVDIDkkSLNIDTKLIEkni---tkrTSAIVPVHVFGNSCNIEeidkl-akryNLKVIYDAAHTFGvk 160 Clostridium acetob...
NP_718741  84 SSSLLwqGIDLAYSDIErsSLNICPEELEknwk-sndsYDSLLATHVYGNPCDVQkidei-akkyNKKIMYDAAHAFGik 161 Shewanella oneiden...
Q50723    126 AQAALwtGYRPWFIDIDanTWQPCVHSARavierfrdrIAGILLANVFGVGNPQIsvweelaaewELPIVLDSAAGFGst 205 Mycobacterium tube...
NP_831714  91 ALAAIwcGLEPYFIDISidDWYMDKTVLLdkieelkeeVAIVIPYATFGSWMNLEkyee--lekkGIPVVVDAAPGFGlm 168 Bacillus cereus AT...
NP_713777  90 FESVVnvGADPYTVDTDpnDLQMDFVEFEkald--kikPKAAIIVHLYGWGSSRLedfrklckskGVPLLEDGAQCFGvk 167 Leptospira interro...
NP_214183  85 IDAVLlaGGIPVVVDVDe-YYTMDVNQLEdavk--kyrPRVVIPVHLYGQPADMEnimfl-adryGFFVLEDCAQAHGae 160 Aquifex aeolicus VF5

Feature 1                          #                                                          
1MDZ_A    169 ykgr--higarGTAIFSFHAIKNI-TCAEGGIVVTDNPQFADKLRSLKFHGlgvdawdrqsggrapqaevlaPGYKYNLP 245 Salmonella typhimu...
AAB84075  180 aggr-pvgafgNAEVFSFHATKAV-TSFEGGAIVTDDGLLADRIRAMHNFGiapdk------------lvtdVGTNGKMS 245 Saccharopolyspora ...
AAO39694  164 dddg-svlrhgDLSVLSFHATKVF-STFEGGAIVCNSKEMKEKIDRLKNFGyidet------------niniIGSNGKMS 229 Escherichia coli
NP_811797 165 rege-silnagDMSTLSFHATKTF-NTIEGGALVLHDEHTKKRVDYLKNFGfvget------------evviPGTNGKLD 230 Bacteroides thetai...
NP_348966 161 ykdk-nilsygDISIISFHATKIF-HTIEGGALVINDDKLYEKAILSRNFGiesad------------sikdLGINAKMN 226 Clostridium acetob...
NP_718741 162 vgnk-svlsfgDASTLSFHATKVF-HTVEGGAVIFKDRNHFDEAKSLINFGiqndg------------tlgtPGINAKLN 227 Shewanella oneiden...
Q50723    206 yadgerlggrgACEIFSFHATKPF-AVGEGGALVSRDPRLVEHAYKFQNFGlvqtr------------esiqLGMNGKLS 272 Mycobacterium tube...
NP_831714 169 nggmhygqdfsGMIVYSFHATKPF-GIGEGGLIYSKNEEDIQHIKRMGNFGfdknr------------ectmMGFNCKMS 235 Bacillus cereus AT...
NP_713777 168 fkga-siykdaLISTTSFYPAKVLgGAGDGGAVFTNDETLANKVKMLANHGrishy------------aygdVGWNSRLD 234 Leptospira interro...
NP_214183 161 fkgk-kvgawgHLSAFSFYASKNV-PMGEGGALTTNDESLFKEVKKWIDFGe-------------------hPAFNVKIT 219 Aquifex aeolicus VF5

Feature 1                                                                                     
1MDZ_A    246 DLNAAIAlAQLQKLDALNARRAAIAAQYHQAMad---lpFQPLSLPswe-hiHAWHLFIIRvdear--cgitRDALMASL 319 Salmonella typhimu...
AAB84075  246 ECAAAMGlTSLDAFAETRVHNRLNHALYSDELrdv--rgISVHAFDp----gEQNNYQYVIisvdsaatgidRDQLQAIL 319 Saccharopolyspora ...
AAO39694  230 EVNAAFGlLQLEHMDTFLRGRMNADMFYRQKLkditgisIVIPSGQk----iSNFSYFPILvesd---fplsRDELFNYL 302 Escherichia coli
NP_811797 231 EVRAAYGlLNLKQVDAAIEARCQATTNYREALrnv--sgITFMDDIsg--vkHNYSYFPIFvdeer--ygmsRDELYFKM 304 Bacteroides thetai...
NP_348966 227 EFEAAMGlCLLDDIDKIFERRKKVYENYMNYIkg----dIYFQSRSrd--ctCNYGYFPIIfkn-----eniLKRVMKEL 295 Clostridium acetob...
NP_718741 228 EYQAAVGlCLLESIDDIICHRSNLFEIYRKELsn----vIELPLWHr----dSNYNGAYMPilps---teveRLKIGEQL 296 Shewanella oneiden...
Q50723    273 EISAAIGlRQLVGLDRRLASRRKVLECYRTGMad---agVRFQDNAn----vASLCFASACcts-----adhKAAVLGSL 340 Mycobacterium tube...
NP_831714 236 EYAAAIGiATIKKWDQKLKERSRISEWYKQLLqn---tgLMKKGWKvqkteaVIHQFMPIIcpe-----evrNIQVIEEL 307 Bacillus cereus AT...
NP_713777 235 TLQAAFLnLNLKHLEVRIASRLKSVQKYYDILpn---lgIQVIHPPk----dYEENGYCNVtlst----peeRPMIQEVL 303 Leptospira interro...
NP_214183 220 EFQAAIGtLQLRKLKERNERRRNIARIYTENLkg----lCEVPEEReg--ayHVYHLYTLRhk--------eRDRLVEHL 285 Aquifex aeolicus VF5

Feature 1                                                                      
1MDZ_A    320 KTKgigTGLHFRAAHtqkyyre----rfptltlPDTEWNSERICSLPLfpdMTESDFDRVITALH 380 Salmonella typhimurium
AAB84075  320 RAEkvvAQPYFSPGChqmqpyr----tepplrlENTEQLSDRVLALPTgpaVSSEDIRRVCDIIR 380 Saccharopolyspora erythraea
AAO39694  303 KNQnifARRYFYPVIpdfqayln---vgevcdvKNAREIASKVLCLPMhaeLSSDILEYIVSTIR 364 Escherichia coli
NP_811797 305 KEYnvlGRRYFYPLIstfstyrel-ksarkenlPVATKMAEQVICLPMhhaLSEDDMERVLRLIR 368 Bacteroides thetaiotaomicron VPI-...
NP_348966 296 INEgvrPRRYFYPCLndlsyi------kdyrkvPVAQDISKRILCLPLydsLNITEQNKIINIVN 354 Clostridium acetobutylicum
NP_718741 297 KANniqFRRYFYPSLdkaylr------vksfncPVSNYIAENALCLPLhmyMTKEDVLKITATIK 355 Shewanella oneidensis MR-1
Q50723    341 RRHaieARDYYNPPQhrhpyfvtnaelvestdlAVTADICSRIVSLPVhdhMAPDDVARVVAAVQ 405 Mycobacterium tuberculosis
NP_831714 308 KKQkieARLYFSPSChqqvlfk----nykstdlTKTNKIAKRIVSLPLwegMTKELVEQIVICLE 368 Bacillus cereus ATCC 14579
NP_713777 304 KEKeigFGNIYPGAMsdqpgakpy-ikgkfgekHITGRICSSVLNYPLfpyMKEEELEEVFSAIR 367 Leptospira interrogans serovar la...
NP_214183 286 RSKgidARVYYTYLLhelrna-------ealptPKAERFKREVFSIPVhpfLKEEEVLYIIESLK 343 Aquifex aeolicus VF5

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