1JAC,1C3M,1JOT,1OUW,1TOQ,1VBO,1ZGR,1ZGR,1ZGR,2JZ4,2JZ4,3MIT,3P8S


Conserved Protein Domain Family
Jacalin
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cd09612: Jacalin 
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Jacalin-like plant lectin domain
Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.
Links
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Statistics
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PSSM-Id: 187708
Aligned: 70 rows
Threshold Bit Score: 91.0886
Created: 12-Nov-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:1JAC: Artocarpus heterophyllus jacalin binds methyl-alpha-D-galactose, contacts at 4 A
  • Citation:PMID 8673603
  • Structure:1JOT: Maclura pomifera lectin MPA binds the T-antigen disaccharide Gal-beta-1,3-GalNAc, contacts at 4 A
  • Citation:PMID 9497359
  • Structure:1C3M: Helianthus tuberosus lectin binds the disaccharide Man-1,3-Man, contacts at 4 A
  • Structure:1VBO: Artocarpus heterophyllus lectin binds mannotriose, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #                                                                               
1JAC_A         1 GKAFDDGaf----tGIREINLSYNKe--tAIGDFQVVYDln----gsPYVGQNHKSFItgfTPVKISLDfpSEYIMEVSG 70  jackfruit
AAT08748      28 GQAWALGpfhdtpfRLLKITVWYGN----AVDGLQFQYElggd-gviIDSPLYGKNMG---TSAEIPLV--DDELTVIRV 97  common hyacinth
AAT08761      27 GKAWTLGpfh-sqfRLLAIRVWTVK----VIDALQFKYEhag---ktHWSPLYGERPSi--EPVEVVIDq-SDPLAVISL 95  common hyacinth
Q5U9T2        15 GSERDVQpk---piRMVSMTVSSGA----IVDAIAFTYVgtdn-vqhSSGIKWGGTGG---TEDTINLDa-TNYVTEISG 82  barley
NP_001052399  16 GDYRDVQva---pyRLVRLTIRSGD----TVDGISFTYIgnd--glvYHMGHWGSDGG---VPHEIHLGl-MDFVMEISG 82  Japanese rice
NP_001065834  15 GTPVDIDhtl-ppdHLKSIKIWYDEd---GINGLKFSYLhaankrklTTTRVWGDDSG---SSDEINIEddDDYVNKLEG 87  Japanese rice
Q0JMY8        14 GSAQDISvp---pkKLLGVTIYSSD----AIRSIAFNYIgvd--gqeYAIGPWGGGEG---TSTEIKLGs-SEQIKEISG 80  Oryza sativa Ja...
P0C5C6        16 GGRVDLSvl---prSLKSVTIRSGA----AIDAIAFTYIgtd--gkeHLAGPWGGGGG---NPTTITLGs-QEFVKGISG 82  Oryza sativa Ja...
NP_001174671  15 GSAQDITvt---piKLTGMTIRSGN----AIDSISFSYSgid--gqeHVVGPWGGNGG---HATTIMLGp-TEHVIEVSG 81  Japanese rice
ADP37001      15 GKLCDINsys-spqRLISITVYSNEtpggCIVGFSFTYVdqt--ggaINVGTWGNTWG---GVKTIYMNq-GEHVNDVSG 87  bread wheat

Feature 1                   #                                             ### #       
1JAC_A        71 YTGNvsg--yvVVRSLTFKTNk-KTYGPYGVTS--GTPFNLPi--eNGLIVGFKGSIGYWLDYFSMYLS 132 jackfruit
AAT08748      98 GPGVgp----dIIAALTFFTNngLFYGPYLRER--GKKLKVEl---NGSIAGFFGHASNHVYGLGIYMK 157 common hyacinth
AAT08761      96 TVGAnp----vGITSIAFLTGkgAAFGPYGQLR--GPQSDIKl---DGGVLGFFGFEQSHIQGFGVFVK 155 common hyacinth
Q5U9T2        83 TVGKfgt--ddIVTSLKIITSk-GVTRTYGSGT--GIPFRVPvl-dGGKIAGFFGRAGAFLDAIGFYIT 145 barley
NP_001052399  83 TTGMwvsgmsnVLRSLKITTLk-RTYGPYGNPKa-GIPFSFSvd-gSDRITGFFVRAGFITDAIGVYVR 148 Japanese rice
NP_001065834  88 RTDGr-----tKIKSLRITTKnnNNPDWLGDKTkeGDYFSVPv--eDGQIVAFFGRTDQYINALGVYIL 149 Japanese rice
Q0JMY8        81 THGPvyd-ladIVTYLKIVTSa-NNTYEAGVPN--GKEFSIPlq-dSGHVVGFFGRSGTLIDAIGIYVH 144 Oryza sativa Japonica Group
P0C5C6        83 TFTN-------VVTNLKIVTN--VTTYNFGQGG--GTAFSLPl--qSGSVVGFFGRAGALVDSIGVYVH 138 Oryza sativa Japonica Group
NP_001174671  82 THGKfgp-vadVVTYLKIVTD--ITTYEFGVRS--GTDFSVPlq-gGAHVVGFFGRFGVLMDAIGIYTR 144 Japanese rice
ADP37001      88 TSNSr------GVTSLKIVTNq-GDRGTYGCPA--GDAFSVPlrqgKNEVVAFFGHSDDTLKSLGVYVP 147 bread wheat

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