Conserved Protein Domain Family
PTZ00164

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PTZ00164: PTZ00164 
bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
Statistics
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PSSM-Id: 240299
Aligned: 16 rows
Threshold Bit Score: 817.757
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
221053708   1 MEDLSEVFDIYAICACCKVtppndgiknepfgprtfR-GLGNNGALPWkCNSVDMKYFSSVTTYVDeskyeklkwkrery 79 
66356564    7 RTFKMSKKNVSIVVAASVL-----------------SrGIGINGQLPW-SISEDLKFFSKITSNNC-------------- 54 
71653378   14 EGTRLALRAFSLVVAVDEH-----------------G-GIGDGRSIPW-NVPEDMKFFRDLTTKLRgkn----------- 63 
72391754   20 KISRPPLRPFSVVVASDEK-----------------G-GIGDGGTIPW-EIPEDMQYFRRVTTNLRgkn----------- 69 
145535888   1 ---MTTNKTFSMVLAMTLN-----------------G-GIGYQNRLPW-KLKEDLQRFKKITT----------------- 41 
154331155  18 SFAFPSLRCFSIIVAVDEQ-----------------H-GIGDGKTIPW-QVPEDMAFFKDQTTLLRnkk----------- 67 
156084246   2 SNSYEGCGDLTIFVAVALN-----------------K-VIGHKNQIPWpHITHDFRFLRNGTTYIPpev----------- 52 
157864294  18 DFAFPSLRAFSIVVALDMQ-----------------H-GIGDGESIPW-RVPEDMTFFKNQTTLLRnkk----------- 67 
118349035   1 ----MKTRHFDIVLAQTLK-----------------KqGIGYKNSLPW-RLPNELKNFKKITTETK-------------- 44 
209878892  13 SEDLKLQKPVIIIVAASTK-----------------EkGIGKGNNLPW-SIKEDLKFFREITCSTIeqsqd--------- 65 
221053708  80 lqreasvgnvethcggdtvetednTTKLQNVVVMGRSSWESIpkQYKPLPNRINVVLSKTLTH--------------EQV 145
66356564   55 ------------------------DSNKKNALIMGRKTWDSI--GRRPLKNRKIVVISSSLPQ--------------DEA 94 
71653378   64 ---------------------vkpSPAKRNAVVMGRKTWDSIppKFRPLPGRLNVVLSSTLTTqhlldglpdeekrnLHA 122
72391754   70 ---------------------vkpSPSKRNAVVMGRKTWDSLppKFRPLSNRLNVVLSRSATKeqllagipdpikraEAA 128
145535888  42 ----------------------------GGIVIMGRKTFESM--NSKPLPNRVNVVISKNMKS----------------- 74 
154331155  68 ----------------------ppTEKKRNAVVMGRQTWESVplKYRPLKGRLNVVLSSKATVdellaal-pegkrtAAA 124
156084246  53 ---------------------lskNPDIQNVVIFGRKTYESIpkASLPLKNRINVILSRTVKE----------------- 94 
157864294  68 ----------------------ppTEKKRNAVVMGRKTWESVpvKFRPLKGRLNIVLSSKATVeellapl-pegqraAAA 124
118349035  45 ------------------------NKGLQNAVIMGKNTWEALpkKQQPLKDRLNIVISTTMQE--------------GQI 86 
209878892  66 -------------------dkentKIEKVNAIILGRKTWDSM--KRIPLKNRKVIVLSRTLQRc------------dNKN 112
221053708 146 KEKVFIIQSIDDLLLLLKK----LKYYKCFIIGGAQVYKECLNR---NLIKQIYFTRI-NNAYQCDVLFPQFDEGQFRMT 217
66356564   95 DPNVIVFRNLEDSIKNLMNd---DTIENIFVCGGESIYRDALKD---NFVDRIYLTRVaLEDIEFDTYFPEIPETFLPVY 168
71653378  123 DSIVAVNGGLEQALRLLASpnytPSIETVYCIGGGSVYAEALRPpcvHLLQAIYRTTIrASESSCSVFFRVPESGTEAAA 202
72391754  129 NDVVAVNGGLEDALRMLVSkehtSSIETVFCIGGGTIYKQALCApcvNVLQAIHRTVVrPASNSCSVFFDIPAAGTKTLE 208
145535888  75 SNEVQVFPRIEDALQFYN-----TSHQKLYLIGGKRIFEEGLAT---DKCSDVHLTRI-GVETKCDVYLNKNIFSTFQVN 145
154331155 125 QDLVVVNGGLAEALHLLARpphcSSIETAYCVGGAQVYSDAMTApcvEKLQEVYLTRIyATAPECTRFYPFPPTNAAAAA 204
156084246  95 VPGCLVYEDLSTAIRDLRAn---VPHNKIFILGGSFLYKEVLDN---GLCDKIYLTRL-NKEYPGDTYFPDIPDTFEITA 167
157864294 125 QDVVVVNGGLAEALRLLARplycSSIETAYCVGGAQVYADAMLSpciEKLQEVYLTRIyATAPACTRFFPFPPENAATAW 204
118349035  87 ADHSYACKSLDSALNFLEQq---NQIQDALVIGGAKLCQQALSD---QRLRQIHLTRV-GVEVECDVFMQKDYLKNFDMI 159
209878892 113 DSGVSIVKSLDEAINLCNNd---ISIHKIVICGGESIYRECIEK---NIVETIYLTRVsTSKKEFDTYFPNIPESFVPIL 186
221053708 218 Sv----------SEVYNNKGTTLDFVIYSKvggevdggaSNgstmdmdsgsencenvkcgapncntsgcispnctstree 287
66356564  169 M-----------SQTFCTKNISYDFMVFEK---------QEkktlqncdp------------------------------ 198
71653378  203 GiewqretiseeLTSANGNETKYYFEKLIP---------RN--------------------------------------- 234
72391754  209 GlelvresitdeRVSTGAGGKKYQFEKLVP---------RN--------------------------------------- 240
145535888 146 Kt----------SQTKSENGINYDYQHLIN---------KN--------------------------------------- 167
154331155 205 Wdlaw----tqgRQRSETGGVEYEIRKYVP---------HN--------------------------------------- 232
156084246 168 I-----------SPTFSTDFVSYDFVIYER---------KDcktvf---------------------------------- 193
157864294 205 Dlas-----sqgRRKSEAEGLEFEICKYVP---------RN--------------------------------------- 231
118349035 160 Ev----------SETQSENNLNYDFTRYFN---------KN--------------------------------------- 181
209878892 187 M-----------SQTFCCNDISYDFMIYEN---------EIlkpikrnir------------------------------ 216
221053708 288 kwrkcspacqwkksnADVEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSVKIKQHPEYQYLSIIYDIIMNGNKQGDRTGVG 367
66356564  199 -------vrgqlksiDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGIS 271
71653378  235 -----------------------------------------------------REEEQYLSLVDRIIREGNVKHDRTGVG 261
72391754  241 -----------------------------------------------------SEEEQYLNLVGRIIDEGCTKCDRTGVG 267
145535888 168 -------------------------------------------SHEQSYIDEEHQENQYLDMITKIMKEGVSKDDRTGVG 204
154331155 233 -----------------------------------------------------HEERQYLELIDRIMKTGIAKEDRTGVG 259
156084246 194 ---------------------pdppFDQLLMTGTDISVPKPKYVACPGVRIRNHEEFQYLDILADVLSHGVLKPNRTGTD 252
157864294 232 -----------------------------------------------------HEERQYLELIDRIMKTGIVKEDRTGVG 258
118349035 182 -------------------------------------YKGQVDPSLFKKMYKPHQEYQYLELIDEIIKNGHVKTDRTGTG 224
209878892 217 ------ntsceseviIPFENVLDKIFGERKISLRNKVPKDDIISYPSIII-RDHPEFQYLDMLSNVLQNGHYRENRTGIN 289
221053708 368 VMSKFGYMMKFNLNEY-FPLLTTKKLFLRGIIEELLWFIRGETNGNTLLKKNVRIWEANGTREFLDNRKLFHREVNDLGP 446
66356564  272 TYSIFGQMMRFDMRES-FPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGP 350
71653378  262 TLSIFGAQMRFSLRNNrLPLLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGP 341
72391754  268 TRSLFGAQMRFSLRNNrLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGP 347
145535888 205 TMSIFGQTMRFNLAQS-FPLLTTKKVFFRGVVEELLWFLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGP 283
154331155 260 ILSLFGAQMRFSLRDNrLPLLTTKRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGP 339
156084246 253 AYSKFGYQMRFDLSRS-FPLLTTKKVALRSIIEELLWFIKGSTNGNDLLAKNVRIWELNGRRDFLDKNGFTDREEHDLGP 331
157864294 259 TISLFGAQMRFSLRDNrLPLLTTKRVFWRGVCEELLWFLRGETSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGP 338
118349035 225 TISQFGKLMRFDLSKS-FPLLTTKNVFWRGVVEELIWFIKGSTNSKILSEKGVKIWDGNGSREFLDQLGFKNREEGDLGP 303
209878892 290 TYSIFGASMRFDLRES-FPLLTTKNVALRIIFEELMWFIKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGP 368
221053708 447 IYGFQWRHFGAEYTNMYDNYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDG--KLSCI 524
66356564  351 IYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDn-CLSCN 429
71653378  342 VYGFQWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNG--ELSCM 419
72391754  348 VYGFQWRHFGADYISCKEDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNG--ELSCM 425
145535888 284 VYGFQWRHFGAKYKDCQTDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANG--KLSCM 361
154331155 340 VYGFQWRHFGAQYKGFEANYDGEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDakELSCM 419
156084246 332 IYGFQWRHFGAEYLDMHADYTGKGIDQLAEIINRIKTNPNDRRLIVCSWNVSDLKKMALPPCHCFFQFYVSDN--KLSCM 409
157864294 339 VYGFQWRHFGADYKGFEANYDGEGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDtsELSCM 418
118349035 304 VYGFQWRHFGAEYKDMHTNYKGKGVDQLQDLINTIKKNPDSRRMIMNAWNVKDLPLMALPPCHVMSQFYVNDN--KLSCM 381
209878892 369 IYGFQWRHFNAEYKTMHDNYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCHILSQFYVDNNn-RLSCS 447
221053708 525 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEVKN--IE 602
66356564  430 LYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVEN--IE 507
71653378  420 LYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREF--LE 497
72391754  426 LYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEF--LE 503
145535888 362 MYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIERVPYPFPLLKIKGNKS---LF 438
154331155 420 LYQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERTPNAFPTLVFKREREF--LE 497
156084246 410 MHQRSCDLGLGVPFNIASYSILTAMVAQVCGLGLGEFVHNLADAHIYVDHVDAVTTQIARIPHPFPRLRLNPDIRN--IE 487
157864294 419 LYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVPHAFPTLIFKEERQY--LE 496
118349035 382 MYQRSCDMGLGIPFNIASYALLTHMIAQVTNMQVGEFIHVLGDAHVYSNHVDQLKIQLERAPYPFPLLKINNNKQYnsIE 461
209878892 448 LYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDVHIYENHVEQLKQQIKRLPRPFPQLRLKRKVDK--VE 525
221053708 603 DFTISDFTIENYVHHDKIAMEMAA 626
66356564  508 DFKWEDIELIGYYPYPTIKMEMAV 531
71653378  498 DYEEGDMEVIDYAPYPPISMKMAV 521
72391754  504 DFQESDIEVIDYSPYPVISMEMAV 527
145535888 439 DYTYEDFELVGYNAHDKIEMKMAV 462
154331155 498 DYELSDMEVIDYAPYPPIKMEMAV 521
156084246 488 DFTIDDIVVEDYVSHPPIPMAMSA 511
157864294 497 DYELTDMEVIDYVPHPAIKMEMAV 520
118349035 462 DFTLEDFELIGYNYHPKIQMKMAV 485
209878892 526 DFIWEDIEIIGYYPHPTIRMEMAV 549
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