2H64,1REU,3BK3,3BMP,1ES7,3BK3,4MID


Conserved Protein Domain Family
TGF_beta_BMP2
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cd19390: TGF_beta_BMP2 
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.
Links
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Statistics
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PSSM-Id: 381660
Aligned: 12 rows
Threshold Bit Score: 221.01
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site 1 [polypeptide binding site]
Evidence:
  • Structure:3BK3; Homo sapiens BMP-2 in complex with Crossveinless-2, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #  #  ##    ###               ### ### #       ##  # ##      # # 
2H64_A        12 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 91  human
1REU_A         1 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPPADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 80  human
3BK3_B        12 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAMYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLM 91  human
3BMP_A        12 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 91  human
1ES7_A        14 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 93  human
P25703       296 SSCRRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNtNIPKACCVPTELSAISMLY 375 African clawed ...
P12643       294 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 373 human
P30884       296 SSCRRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNtNIPKACCVPTELSAISMLY 375 African clawed ...
Q90751       251 YSCKRHPLYVDFNDVGWNDWIVAPPGYSAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLY 330 chicken
3BK3_A        12 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAMYCHGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTELSAISMLM 91  human
XP_006002675 331 PRCKRHPLFVDFKDVGWNKWIVAPSGYRAFYCHGECRFPLVDHMNSSSHAMVQTLVNSVNsKVPRACCVPTDLSPIAMLY 410 coelacanth
4MID_A        13 SSCKRHPLYVDFSDVGWNDWIIAPSGYHANYCDGECPFPLADHLNSTNHAIVQTLVNSVNsKIPKACCVPTKLRPMSMLY 92  human

Feature 1              ######### #     #
2H64_A        92 LDEnEKVVKKDYQDMVVEGCGCR 114 human
1REU_A        81 LDEnEKVVLKNYQDMVVEGCGCR 103 human
3BK3_B        92 LDEnEKVVLKNYQDMVVEGCGCR 114 human
3BMP_A        92 LDEnEKVVLKNYQDMVVEGCGCR 114 human
1ES7_A        94 LDEnEKVVLKNYQDMVVEGCGCR 116 human
P25703       376 LDEnEKVVLKNYQDMVVEGCGCR 398 African clawed frog
P12643       374 LDEnEKVVLKNYQDMVVEGCGCR 396 human
P30884       376 LDEnEKVVLKNYQDMVVEGCGCR 398 African clawed frog
Q90751       331 LDEnEKVVLKNYQDMVVEGCGCR 353 chicken
3BK3_A        92 LDEnEKVVLKNYQDMVVEGCGCR 114 human
XP_006002675 411 LDQhERVVLKNYNDMVVEGCGCR 433 coelacanth
4MID_A        93 YDDgQNIIKKDIQNMIVEECGCS 115 human

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