1IRA,1ILR,1IRP,2IRT,4GAF


Conserved Protein Domain Family
beta-trefoil_IL1RA

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cd23297: beta-trefoil_IL1RA 
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins
IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 466779
Aligned: 15 rows
Threshold Bit Score: 255.06
Created: 5-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimerheterodimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1ILR; Homo sapiens IL1RA forms a homodimer, contacts at 4A
  • Citation:PMID 7867645

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #  ##             ###                                                   
1IRA_X         8 SKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNvnLEEKIDVVPi-----EPHALFLGIHgGKMCLSCVKs------GDET 76  human
1ILR_1         8 SKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNvnLEEKIDVVPi-----EPHALFLGIHgGKMCLSCVKs------GDET 76  human
1IRP_A         9 SKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNvnLEEKIDVVPi-----EPHALFLGIHgGKMCLSCVKs------GDET 77  human
2IRT_A         8 SKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNvnLEEKIDVVPi-----EPHALFLGIHgGKMCLSCVKs------GDET 76  human
P18510        33 SKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNvnLEEKIDVVPi-----EPHALFLGIHgGKMCLSCVKs------GDET 101 human
NP_001257464  17 TKVFKYRIWDMNQQSLYLRDDQLVAGHLQGANaaLEEKVFWVPnrffkhELQPVIMGIRnGTRCLACPA-------APQP 89  chicken
XP_005062776  16 TEVFQYRLWDVNQRSLYLRDGHLVAGHLQGANaaLEEKVFWVPnralepARLPVILGIQhGSRCLSAERg-----pRGEP 90  Collared flycat...
XP_014749620  85 TKVFQYRLWDVNQRSLYLRDGQLVAGHLQGANavLEEKVFWVPnrafepARLPVILGIRhGSRCLRAQSg-----tAGEP 159 Common starling
XP_015276612  14 AMVFRSRIWDVNQKSLYLQNDELVAGYLQGPNsaLEEKIYWIPnrnfnrEKFPIILSIKdGSQCLACSF-------GAQP 86  Gekko japonicus
TRZ09413      16 TKVFQYRLWDVNQKSLYLRGDQLLAGHLQGANaaLEEKVFWVPnralepARLPVILGIRrGSRCLRADSdsdsdssGGEP 95  Zosterops borbo...
Feature 1                                                                         ###        
1IRA_X        77 RLQLEAVNITDLsenr-kqdkRFAFIRSDSGPTTSFESAAcPGWFLCTAMEADQPVSLTNMPdegVMVTKFYFQED 151 human
1ILR_1        77 RLQLEAVNITDLsenr-kqdkRFAFIRSDSGPTTSFESAAcPGWFLCTAMEADQPVSLTNMPdegVMVTKFYFQED 151 human
1IRP_A        78 RLQLEAVNITDLsenr-kqdkRFAFIRSDSGPTTSFESAAcPGWFLCTAMEADQPVSLTNMPdegVMVTKFYFQED 152 human
2IRT_A        77 RLQLEAVNITDLsenr-kqdkRFAFIRSDSGPTTSFESAAcPGWFLCTAMEADQPVSLTNMPdegVMVTKFYFQED 151 human
P18510       102 RLQLEAVNITDLsenr-kqdkRFAFIRSDSGPTTSFESAAcPGWFLCTAMEADQPVSLTNMPdegVMVTKFYFQED 176 human
NP_001257464  90 TLQLQDADITELprsg-aasaPFTFFRTYKDGLWRFESAAnPGWFLCTSARAHQPLGLSRRPd-aAHVLDFYFQLC 163 chicken
XP_005062776  91 RLSLQDVDIRELprag-dsaaAFTFFRSYRDGLWRFESAAhPGWFLCTAPRGHQPLALCRHRdvaSNLIDFYFQLC 165 Collared flycatcher
XP_014749620 160 RISLQDVDIRELprag-dsaaAFTFFRSYRDGLWRFESAAhPGWFLCTSPRGHQPLALCRHRdvtSNLLDFYFQLC 234 Common starling
XP_015276612  87 VLQLESIRISDLyndskedstRFTFFRSYKNGMWRFESAShPGWFLCTSSRSNEPLGLTQNPg-sAHVIDFYFQLL 161 Gekko japonicus
TRZ09413      96 RLSLQDVDIRELprag-dsaaAFTFFRSYRDGLWRFESAAhPGWFLCTSPRGHQPLALCRRRdltSHLVDFYFQLC 170 Zosterops borbonicus

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