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C-terminal coiled coil domain found in Saccharomyces cerevisiae silent information regulator 4 (Sir4p) and similar proteins Sir4p is a regulatory protein that plays important roles in silent chromatin at telomeric and silent mating type loci. It physically interacts with another two silent information regulators, Sir2p and Sir3p, to form a complex that may regulate chromatin structure. The C-terminus of Sir4p is critical for its functions in vivo. This model corresponds to the C-terminal coiled coil domain of Sir4. Coiled coil dimerization is essential for telomeric and mating type silencing in Saccharomyces cerevisiae.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",