Conserved Protein Domain Family
Fzo_mitofusin

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pfam04799: Fzo_mitofusin 
fzo-like conserved region
Family of putative transmembrane GTPase. The fzo protein is a mediator of mitochondrial fusion. This conserved region is also found in the human mitofusin protein.
Statistics
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PSSM-Id: 461432
Aligned: 22 rows
Threshold Bit Score: 198.695
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009027995 576 DDnELMVSLLSAFSSLYSGTTIGVLAIAA-L-------------------------------------L----GKAAGWR 613
4_pfamImport   2 PE-DFLWSLASGYFKFTKSHSTLFVVCLG-M-------------------------------------VpyvfWRSIGWR 42 
XP_004365821 717 AEaALTLADRVGLVLSTPSSYAVVTILAT-L-------------------------------------V----TRPGVWK 754
O18412       563 NHwQMLESL------VKSKGSLGTVLLSA-M-------------------------------------A----IRSFNWP 594 fruit fly
CRZ23693     611 QEnAMMAQLILSSIGYVANGSLGLLVIGG-I-------------------------------------V----SKAISWR 648
XP_003243736 602 EQ-NLSMISRVVAASVGTQGTVGGLVLAG-F-------------------------------------M----LKTVGWR 638
Q7PY95       618 NE-QLSVISKVAIASIGSQGTLG-LVVAG-L-------------------------------------M----LKTIGWR 653 Anopheles gambi...
XP_002009525 646 PE-QLSVISRFALSSIGSQGTVGGLVVAG-I-------------------------------------M----LKTIGWR 682
EDO42379     594 DE-EMTLAVIHGVASLTSRTATVVVLAGG-L-------------------------------------L----WRVMGWR 630
XP_013121487 523 DF-QFSLGWTALVTRFIGASNAKRALSGAdCahkerstfrdemvvsiatglvsvtsrasmtvlviggvV----WRSVGWR 597 Nile tilapia
XP_009027995 614 VIGLCGGIYGLLYLYERITWTNSAKEKAFKRQYVDYASGKLRLIVDLTSANCSHQVQQELNSTFGRLCQQVEMTKNDLED 693
4_pfamImport  43 VVAFSAVSYSALYGYERLTWTSRAKERALKRQFVEHATDKLNLIISFTSSNCSHQVQQELSGTFARLCCDVDEVRNEIEE 122
XP_004365821 755 LAALSGAAFGSLYLYEYALYTNGAKERRFKEQFTRHAASELRRSVRQTSHTVSISLQSRLSFYVDELRNAVRQTEATLTA 834
O18412       595 IVLILGGLVGSFYIYEYAAWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLATVRNCWEAQSNETLNDLNV 674 fruit fly
CRZ23693     649 FIAAGIALYGGLYAAEYWRWNSGAKEQHLKDQFRHHLNARMRSVATTHTLHCETQVLREMQQVLGGLKSTVGGVHQEMKT 728
XP_003243736 639 LIVAAGAVYGVLYLYERLSWTTKAKEREFKRQYVDHATAKLRLIVDLTSANCSHQVQQELSTTFARLCQLVDESATNLND 718
Q7PY95       654 VIVGAGVIYGSVYLYERLSWTNTAKERNFKNQYVDHATRKLKLIVDLTSANCSHQVQQELSSTFARLCRVVDTASTEMNE 733 Anopheles gambi...
XP_002009525 683 VLVGIGALYGCIYLYERLSWTNSAKERAFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNE 762
EDO42379     631 IIICCTGLYGGLYVIERLRWTNSAKEKTFKRQFVDFASEKLQLVVSFTSSNCGLQVQQELSSTFSRLQSLVHRSKENLED 710
XP_013121487 598 LIALSVSLYGLLYLYEKLTWTDASRERALKQQFVEHAAQRLRAVVPVASNACSHQVCKELLSTFSRLTQRVELSDAELEG 677 Nile tilapia
XP_009027995 694 ELKNLEVEITKLDEASKQAICLKNKTQFVDTELSNFMLQYLK 735
4_pfamImport 123 ESEALLSKCSHLAKVQTQSKTLRNKAGWLAAELDAFARTYLT 164
XP_004365821 835 EIARAEREVAMMQDAISKAGLLHHEALSIRKGLADAQETFID 876
O18412       675 RTAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLT 716 fruit fly
CRZ23693     729 ELDNMRREIEKIDHVTKGLNTIKGKASFLNTDLDRFENEFLK 770
XP_003243736 719 EMKNLDRELNMLTKSTEIAKILRNKADLLKVELKQFDDTFLc 760
Q7PY95       734 ELKQIESSLGVIETNQKQIKLLKNKANYIMNELEIFDSNYIK 775 Anopheles gambiae str. PEST
XP_002009525 763 ELKTLEAQLNVLESNQKQLKLLRNKANYIQNELDIFEHNYIA 804
EDO42379     711 EILELEAEITRLESIESRARVLKNKACWFESELVDFLKTFGL 752
XP_013121487 678 NIRQLSFRIQRLENIQRRSKAFRNrateletqlevfsvqylq 719 Nile tilapia
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