1WEV


Conserved Protein Domain Family
PHD_Int12
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cd15501: PHD_Int12 
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PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
Int12, also termed IntS12, or PHD finger protein 22, is a component of integrator, a multi-protein mediator of small nuclear RNA processing. The integrator complex directly interacts with the C-terminal domain of RNA polymerase II (RNAPII) largest subunit and mediates the 3' end processing of small nuclear RNAs (snRNAs) U1 and U2. Different from other components of integrator, Int12 contains a PHD finger, which is not required for snRNA 3' end cleavage. Instead, Int12 harbors a small microdomain at its N-terminus which is necessary and sufficient for Int12 function; this microdomain facilitates Int12 binding to Int1 and promotes snRNA 3' end formation.
Links
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Statistics
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PSSM-Id: 276976
Aligned: 24 rows
Threshold Bit Score: 73.1481
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding siteputative
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #              #  #    #  #                   #  #
1WEV_A        18 ACVVCRQmtv-asgNQLVECQECHNLYHQDCHKPQVtdke-vndpRLVWYCARC 69  house mouse
EFX79629      76 HCVICTGldv-tsgNQLVECQECHGLYHQECHQPNIsdae-vndpRSVFFCSDC 127 common water flea
XP_002125955 159 SCAICNDmtv-gsgNQLVECHECHNLFHQECHQPHIsdqy-vndpRCIWNCAHC 210 Ciona intestinalis
EFN68428     119 TCVICKGmdv-garNRLVECQECHSLYHQECHIPHIldsq-idvpKQVWYCSNC 170 Camponotus floridanus
ACO12619     128 TCVICKSlnq-engNILMECHTCQNLYHQECHSPMVsndd-addpRLIWHCSQC 179 salmon louse
NP_001135859 120 ACVICKGmdy-gakNRLVECNKCGAMYHQECHTPPVldtq-idttPVERYCYSC 171 jewel wasp
NP_651507    130 NCCVCGEmvf-tatNRLIECSKCGAMYHQECHKPPItkeeaaddqEQNWQCDTC 182 fruit fly
XP_003369948 186 SCVMCKNgts-tsdNALVKCQMCSKMYHQKCHVPKVpedq--vdpRVLWYCKEC 236 Trichinella spiralis
XP_006610425 152 LCKICNGakl--gpLILLECQECQEVYHPLCHQPPVvdid-vydpRIVWRCRKC 202 giant honeybee
CBY10361     103 GCKTCGDpsikgkqGLKVECSECHQYFHQECHKPPVptat-asdpRTIWKCSQC 155 Oikopleura dioica

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