1WEX


Conserved Protein Domain Family
RRM1_hnRPLL

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cd12781: RRM1_hnRPLL 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
This subgroup corresponds to the RRM1 of hnRNP-LL, which plays a critical and unique role in the signal-induced regulation of CD45 and acts as a global regulator of alternative splicing in activated T cells. It is closely related in domain structure and sequence to heterogeneous nuclear ribonucleoprotein L (hnRNP-L), which is an abundant nuclear, multifunctional RNA-binding protein with three RNA-recognition motifs (RRMs), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Statistics
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PSSM-Id: 410173
Aligned: 5 rows
Threshold Bit Score: 178.694
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putative RNA
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on sequence similarity to Homo sapiens polypyrimidine tract binding protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # ##                       # #  ### #                              #####  
1WEX_A        13 SVSPVVHVRGLCESVVEADLVEALEKFGtICYVMMMPFKRQALVEFENIDSAKECVTFAADvpVYIAGQQAFFNYSTSKR 92  house mouse
NP_001120904  62 SVSPVVHVRGLCESVVEADLVEALTKFGpICYVMMMPFKRQALVEFEDIEFSKKCVAFAASepVYIAGQQAFFNYSTSKR 141 western clawed ...
NP_001133491  78 AQSPVVHVRGLCEAVVEADLVEALEKFGpICYVMMMPFKRQALVEFEMVESADKCVACGSSeaVYIAGQQAFFNYSTSKR 157 Atlantic salmon
NP_001292580  74 SVSPVVHVRGLCESVVEADLVEALEKFGtICYVMMMPFKRQALVEFEKVESAKKCVTFAADepVYIAGQQAFFNYSTSKR 153 chicken
XP_006007838  11 SLSPVVHVRGLCESVVEADLMEALERFGtICYVMMMPFKRQALVEFENVDCAKKCVTFAADqpVYIAGQQAFFNYSTSKR 90  coelacanth
Feature 1            
1WEX_A        93 ITRP 96  house mouse
NP_001120904 142 ITRP 145 western clawed frog
NP_001133491 158 ITRP 161 Atlantic salmon
NP_001292580 154 ITRP 157 chicken
XP_006007838  91 ITRP 94  coelacanth

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