1ZJ6,1YZG,1Z6Y


Conserved Protein Domain Family
Arl5_Arl8
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cd04153: Arl5_Arl8 
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Arf-like 5 (Arl5) and 8 (Arl8) GTPases
Arl5/Arl8 subfamily. Arl5 (Arf-like 5) and Arl8, like Arl4 and Arl7, are localized to the nucleus and nucleolus. Arl5 is developmentally regulated during embryogenesis in mice. Human Arl5 interacts with the heterochromatin protein 1-alpha (HP1alpha), a nonhistone chromosomal protein that is associated with heterochromatin and telomeres, and prevents telomere fusion. Arl5 may also play a role in embryonic nuclear dynamics and/or signaling cascades. Arl8 was identified from a fetal cartilage cDNA library. It is found in brain, heart, lung, cartilage, and kidney. No function has been assigned for Arl8 to date.
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Statistics
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PSSM-Id: 133353
Aligned: 14 rows
Threshold Bit Score: 299.65
Created: 1-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1ZJ6: Human Arl5 binds GDP3'P, a GTP analog, defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #######                                                  
1ZJ6_A      3 ILFTRIWRLFNHq-EHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVIn------nTRFLMWDIGGQESLRS 75  human
1YZG_A      3 LIFAKLWSLFCNq-EHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEIVVk------nTHFLMWDIGGQESLRS 75  human
1Z6Y_B      3 ILFTRIWRLFNHq-EHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVIn------nTRFLMWDIGGQESLRS 75  human
XP_761700   3 VAFSSLWTSLFGskELKICILGLDNAGKTTLMYKMTLGSVVSTAPTVGSNTEQFEYk------nLKFMLWDVGGQTSLRT 76  Ustilago maydis 521
NP_499178   3 LIMAKLFQSWWIgkKYKIIVVGLDNAGKTTILYNYVTKDQVETKPTIGSNVEEVSYr------nLDFVIWDIGGQESLRK 76  nematode
AAN78415    4 RLFTKFWRLFNSr-VYKVIILGLDNAGKSTILYQFVLKEAVQTSPTIGSNVEEVKWk------nLHFVMWDIGGQTSVRA 76  Schistosoma japonicum
AAW45627    3 VTFSSLWSRLFArkETKVLLIGLDNAGKSTILYRITTGAVVASAPTVGSNHEIYDYk------gVRFGLIDIGGQTSLRS 76  Cryptococcus neofo...
EAN89130    3 TLFSSFWSLFVPsrNYKLVILGLNNAGKTSILYHLQLGHAITTQPTLGGNMEQLSVahgpnnntIQFTCWDLGGQEQLRD 82  Trypanosoma cruzi
NP_188935   3 AFMSRFWFMMFPakEYKIVVVGLDNAGKTTTLYKLHLGEVVTTHPTVGSNVEELVYk------nIRFEVWDLGGQDRLRT 76  thale cress
XP_645417   6 SIFASIWNRFFNnaEYKVIIVGLNAAGKTTTLYKLLLDEVVSTTPTVGSNLEEFVYr------nIRLLMWDLGGQDLLRS 79  Dictyostelium disc...

Feature 1                                                       ## #                          
1ZJ6_A     76 SWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEd-LRKAGLLIFANKQDVKe---cMTVAEISQFLKLTSIk-dH 150 human
1YZG_A     76 SWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEd-LRKAAVLIFANKQDMKg---cMTAAEISKYLTLSSIk-dH 150 human
1Z6Y_B     76 SWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEd-LRKAGLLIFANKQDVKe---cMTVAEISQFLKLTSIk-dH 150 human
XP_761700  77 SWTSYLASTDAVIFVLDSNDRERVTLARQELHRIAQDEq-VAKAPILVWANKQDIKg---aMTPAEISESLALTAFr-eR 151 Ustilago maydis 521
NP_499178  77 SWSTYYVQTDVVIVVIDSSDTTRIPIMKEQLHNMLQHEd-LARAHILVLANKQDLPg---aMNPAEVSTQLGLQTLrgaR 152 nematode
AAN78415   77 SWTTYFSGSDFVILVIDSTDRERLCLTKQELYKLLIAEe-LKRSKMLIFANKQDVSg---cMSVAEISHNLNLTSIr-dH 151 Schistosoma japonicum
AAW45627   77 SWSQYFNGTEAVILVIDSCDGPRLGLVKQELMKIVADEs-LSTALLLVLANKQDLPvsqgrLTPAQISEALSLTDLr-qR 154 Cryptococcus neofo...
EAN89130   83 SWALYYEQTDAVIFVVDAADVSRFAVARKVLQGLLNNEpcLRKAVLLVLANKQDLRg---aVSPVEMIEALGLGAVr-dH 158 Trypanosoma cruzi
NP_188935  77 SWATYYRGTHAVIVVIDSTDRARISFMKDELARLLGHEd-LQNSVILVFANKQDLKd---aMTPAEITDALNLHSIk-nH 151 thale cress
XP_645417  80 TWNQYYINTQAVILVIDSTDRARVNLIKEELFKMLAHEn-LKKSIILIYANKQDLKd---aMSPTELSTLLSLHSIk-dH 154 Dictyostelium disc...

Feature 1            ##                
1ZJ6_A    151 QWHIQACCALTGEGLCQGLEWMMSR 175 human
1YZG_A    151 PWHIQSCCALTGEGLCQGLEWMTSR 175 human
1Z6Y_B    151 QWHIQACCALTGEGLCQGLEWMMSR 175 human
XP_761700 152 TWQIFGCSALTGKGLTEGLDWLAHT 176 Ustilago maydis 521
NP_499178 153 KWQINGCCAVKGEGLPEALEWIANN 177 nematode
AAN78415  152 PWHVQPCCALTGEGLPQGLDWIATQ 176 Schistosoma japonicum
AAW45627  155 EWQIMGCSALTGAGLMEGMDWLVTN 179 Cryptococcus neoformans var. neoformans JEC21
EAN89130  159 TWTLMGCSAATGASLREAMAWVAQK 183 Trypanosoma cruzi
NP_188935 152 DWHIQASCAVTGEGLYDGLGWIAQK 176 thale cress
XP_645417 155 DYHIQACCALTGQGLESGLDWLVSH 179 Dictyostelium discoideum

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