1AZS,1GOT,3AH8,1ZCB,1ZCA


Conserved Protein Domain Family
G_alpha

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smart00275: G_alpha 
G protein alpha subunit
Subunit of G proteins that contains the guanine nucleotide binding site
Statistics
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PSSM-Id: 214595
Aligned: 48 rows
Threshold Bit Score: 301.034
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AZS_C    20 REANKKIEKQLQKDKQVYr----------ATHRLLLLGAGESGKSTIVKQMRILHVNGFNGDgEKATKVQDIKNNLKEAI 89  cattle
P34045    51 KAVNKQIEKQLKEEKKIMd----------sELKLLLLGTGDSGKSTVVKQMKILHLEGYSQE-ERINQRQFVYRNIIEIA 119 Dictyostelium disco...
CAA98948  21 VEHNKSIENDLEKDRKIK------------ILKLLILGPGESGKSTTIKQIKIIHDEGYSAE-EKMVRKHGIYMNILEGI 87  Caenorhabditis elegans
P28051    13 AKQNKIINTELDKAKKTDe----------NIIKLLLLGAGESGKSTVLKQMKIIHNSGFSQE-EISNKRNVVCANTVQAM 81  Caenorhabditis elegans
AAB88395  57 LQKHKSIEKQLQLDGKNKnk--------iPVLKLLLLGTGESGKSTVVKQMKILHHKGFSKE-EEEFYRNLIYINLLDGM 127 Dictyostelium disco...
AAA97988  17 IKVNKEIEKQLEKKKNMQl-----------EQTVLLLGPGESGKSTVMKQMRAMTGN-YTKT-ELHERKVLIIQNLCQFS 83  Caenorhabditis elegans
P49082    19 NTQTAEIERRIELETKAEk----------HIQKLLLLGAGESGKSTIFKQIKLLFQTGFDEA-ELKSYQPVIHANVYQTI 87  Lotus japonicus
CAA87631   9 VARSRSIDHQLDEERERRe----------KEVQILIIGGPGAGKSTFIKQLRLHYGDQFPPN-ERRLFHDQILQNVAMGL 77  great pond snail
AAB52648  13 ELQNRQIDTQIRIENQANk----------RKIKMLLLGVTDSGKSTIVKQMRVNYLDGFNET-EVVNAIFVIRNNIIDAF 81  Caenorhabditis elegans
CAA99780   5 FSSQSKLQVPEIRASRSItpasqksedpysHIRLLLLGSAESGKTTVLEQVRLLYKQHFTES-EYFHRRAFIYHNIFKSI 83  Caenorhabditis elegans
1AZS_C    90 ETIVAAMSNLVPPVELANpe--------nqFRVDYILS------VMNVPDfd---------------------------- 127 cattle
P34045   120 YSIIRGCGVLNLTIPSQFd------------sICSSIEei---yETKNYTnl---------------------------- 156 Dictyostelium disco...
CAA98948  88 EEIHLSVGRENKSYKNPLsfd-------hinEVRMFTEnf---kKADDSEkl---------------------------- 129 Caenorhabditis elegans
P28051    82 GALLDGMKQLQFDFSTRVc----------nAHEKLIREt-----LNDKAEygp--------------------------- 119 Caenorhabditis elegans
AAB88395 128 ALLIHVIKENNIEIPQETlsai----knysSWYRVYIE------KRNKNGirnnpigsmipisilnnnkdnnnsnssslk 197 Dictyostelium disco...
AAA97988  84 EMLLEYVREYILEMTEDDd-----------KRYTVMCEe----lKMAVIHdgi--------------------------- 121 Caenorhabditis elegans
P49082    88 KLLHDGAKELAQNDVDF---------------SKYVISdenkeiGEKLSEiggrld------------------------ 128 Lotus japonicus
CAA87631  78 VHLIEHMERMGLQFETPEvqdlsrefrkkhPRISIVTLikkfkeENEKAEeicpvttraelt------------------ 139 great pond snail
AAB52648  82 KNICNIILHSDITVTQEEk------------VLVKLFAy-------ESGKiel--------------------------- 115 Caenorhabditis elegans
CAA99780  84 KALCRAMRMSDIQFADPIn----------mGRAQSIIA-------DEHGHygl--------------------------- 119 Caenorhabditis elegans
1AZS_C   128 -------------------------------------------------------------------fpPEFYEHAKALW 140 cattle
P34045   157 --------------------------------------------------------------------dKNVLKGVAELS 168 Dictyostelium disco...
CAA98948 130 -------------------------------------------------------------------lgPEVINAIQKYI 142 Caenorhabditis elegans
P28051   120 -------------------------------------------------------------------fsDAMFNALTELW 132 Caenorhabditis elegans
AAB88395 198 nnsggsssseldkkmthlsldgstcinsnsaspngpssstttstinthnrsnsdgssnnifnvqdfgipPIITNYISTIW 277 Dictyostelium disco...
AAA97988 122 -------------------------------------------------------------------mrPELADTLKEFW 134 Caenorhabditis elegans
P49082   129 ----------------------------------------------------------------ypcltKELALEIENLW 144 Lotus japonicus
CAA87631 140 ---------------------------------------------------------krlssfdvynpeVPNVDDMHTLW 162 great pond snail
AAB52648 116 ------------------------------------------------------------------mqeVDELNVINAVS 129 Caenorhabditis elegans
CAA99780 120 -------------------------------------------------------------------fsKDLAEKIKHIW 132 Caenorhabditis elegans
1AZS_C   141 EDEGVRACYE-RSNEY---QLIDC-------------------------AQYFLDKIDVIKQDDYVPSDQDLLRCRVLTS 191 cattle
P34045   169 KNESFINAANnSGSNF---QLHSSsq-------------------------yFLDDIARFSEEDYIPTDQDILYTRVAST 220 Dictyostelium disco...
CAA98948 143 KDETIAMMLR-DKTVY---NIDDSti-------------------------yFLENFSRIIQKDYLPTEEDILKSRVPTS 193 Caenorhabditis elegans
P28051   133 ADKGVQCAYD-KREFF---YLHDS-------------------------AKYFLDRIARVHTPNYVPTENDILHTRVPTM 183 Caenorhabditis elegans
AAB88395 278 SDPVVQSEVMlQAQKY---HINES-------------------------TQYYLNEIKRIGKPTYQPVNLDILKSRATTN 329 Dictyostelium disco...
AAA97988 135 GNSAIQDAYS-KRDTF---HLTDSakkmfqliqkhvskmsemflkiffyVTHFFDNIDRIKLPGFEPTNQDIVHIRVPTT 210 Caenorhabditis elegans
P49082   145 KDAAIQETYA-RGNEL---QVPDC-------------------------THYFMENLHRLSDANYVPTKDDVLYARVRTT 195 Lotus japonicus
CAA87631 163 ADPAMQICFE-KRNKFetdKLTHS-------------------------SEYFLLHIGRICSKEYLASVQDILLIRWPTL 216 great pond snail
AAB52648 130 GYECIKQFFE-RFAFHp--MVPDH-------------------------IHYFYPNLDRIASSNYVPTAEDLIHMRQTTL 181 Caenorhabditis elegans
CAA99780 133 NDKSMQKLYA-RRSQF---NLNDS-------------------------ASYFLNNIDKINMVDYKPSERDLIMAYVPTC 183 Caenorhabditis elegans
1AZS_C   192 GIFETKFQVDKVNF------HMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQT---------------- 249 cattle
P34045   221 SVSETRFSVRGIKf------RMIDVAGQRGHRDKWIHHFSEVTAILFVISLCEYDQVLEEDGKT---------------- 278 Dictyostelium disco...
CAA98948 194 GVIQYKIMLKNFNf------RIFDVGGQRAQRRKWLHVFDDVQAVLFITSLSEYDQVLREDATV---------------- 251 Caenorhabditis elegans
P28051   184 GVIEVNFTIKGKFF------RVFDVGGQRSQRKKWIHCFDDAKAMIYVASLSEYDQVLLEDNTT---------------- 241 Caenorhabditis elegans
AAB88395 330 GVVETDFNVNGEVIf-----RIVDVAGQRGERKKWINFFDDVTAIVFVAAINEYDQKLVEDNCT---------------- 388 Dictyostelium disco...
AAA97988 211 GVAQVEVIMNNIKL------MICDCGGQRSERRKWYHFFDEADAVLFVAAISEFDQKLAEDEET---------------- 268 Caenorhabditis elegans
P49082   196 GVVEIQFSPVGENKksgevyRLFDVGGQRNERRKWIHLFEGVSAVIFCAAISEYDQTLFEDENK---------------- 259 Lotus japonicus
CAA87631 217 GVQEHKFMVDGLLY------RMIDVAGQRSLRKKWIHFFDEVAAVAFFVNLTAYDEFTEEDPTV---------------- 274 great pond snail
AAB52648 182 GVHEISFDYTKHII------RLIDVGGQKTERRKWIHFFEGVTAVMFVCSLASFNQTTEEEPKAfvwesslnkvqnkvlv 255 Caenorhabditis elegans
CAA99780 184 GVQNVIFTACNQSF------QLFDIGGQKIDRRKWALQYEGIDAIFFCIAISEYDQVMSEDMVT---------------- 241 Caenorhabditis elegans
1AZS_C   250 --------------NRLQEALNLFKSIWNNRWLRT-ISVILFLNKQDLLAEKVLAGksKIEDYFPEFARyttpedatpep 314 cattle
P34045   279 --------------NRMIESIKVFGDIINQRLFKD-IPIILFLNKRDLFAEKIKKT--GISICFPDYTGp---------- 331 Dictyostelium disco...
CAA98948 252 --------------NRMKESLNLFEKICNGRYFLN-TAMILFLNKIDLFKIKIKHT--NITVALTSYKGp---------- 304 Caenorhabditis elegans
P28051   242 --------------NRMHESIQLFKQVINNKYFVN-TSVILFLNKIDLFEEKIVTKkrSLGIAFESFSGp---------- 296 Caenorhabditis elegans
AAB88395 389 --------------NRLHESLNLFDSICNDSTFPK-TSIILFLNKIDLFREKLKRT--SINICFPDYNGd---------- 441 Dictyostelium disco...
AAA97988 269 --------------NRMHESIRLFWTVFNGKFFKK-AAVILFLNKIDLFEEKVKHV--KIKDYFPKFEGa---------- 321 Caenorhabditis elegans
P49082   260 --------------NRMMETKELFEWVLKQPCFEK-TSFMLFLNKFDIFEKKILKVplNVCEWFKDYQPvst-------- 316 Lotus japonicus
CAA87631 275 --------------NSLQDSLQAFAEISHSQFLDK-TDFILFLNKKDLFANKLKTS--SIATCFPDYKGp---------- 327 great pond snail
AAB52648 256 rsagkakvekpgliNRLDESVDLFKSIREN-SFLKmSNFMLFLNKKDLLTKKLTKV--VFSDYFPDYKKwit-------- 324 Caenorhabditis elegans
CAA99780 242 --------------NRLDDALNLLQSISEDPAFAT-TPIYLFLNEIDVFCEKLSVI--PLSKYKPDFKGg---------- 294 Caenorhabditis elegans
1AZS_C   315 gedPRVTRAKYFIRDEFLRISTas---gdGRHYCYPHFTC-AVDTENIRRVFNDCRDIIQRMHLRQYE 378 cattle
P34045   332 --sDDYEQSLVFLKKKILSANKt-------sKAVYTNVTT-ATDTTNIGHVFEAVKDILTRQTMEEGG 389 Dictyostelium discoideum
CAA98948 305 ---QECDSALDYIRKRFISLNKn------KKRSIYEHVTC-ATDTEQIQVVIDSVIDVVIQHTMQKVG 362 Caenorhabditis elegans
P28051   297 --sQDLNAAVAFVEKKYRSMAEn------KEKNIYCHHTC-ATDTQQVQYVLDAVLDTILSTKLKGCG 355 Caenorhabditis elegans
AAB88395 442 ---QSYEKSSNYIKNNFLSKKKggn-ginSQNFIYFHFTC-ATDTKSFETVFNSVRDIIISKTLEFYC 504 Dictyostelium discoideum
AAA97988 322 ---NTVSEGTKFFRRQFREGIHp-----dFKKRMYTHETC-AIS-DQVQIIINTVIDTVIQDNLKDTG 379 Caenorhabditis elegans
P49082   317 -gkqEIEHAYEFVKKKFEESYFqntapdrVDRVFKIYRTT-ALDQKVVKKTFKLVDETLRRRNLFEAG 382 Lotus japonicus
CAA87631 328 ---NTVDASLKYIKEQFLQSKP-------AQKQVYSHATC-AIDVPHMKDLLATVVDCIVDINVKRSK 384 great pond snail
AAB52648 325 -ndNSDVSVAEFIENMFREGLE-------PEKRMYAHLTQ-ATVTANIEGTFALCCDVIFGKNYEDTN 383 Caenorhabditis elegans
CAA99780 295 ----DQDDAIDFMENLACEALGk------rDRSLYRVYRCiAIDTQMMAELLSTCFLKKERRLIRYAN 352 Caenorhabditis elegans
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