1V9X


Conserved Protein Domain Family
zf-PARP

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pfam00645: zf-PARP 
Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA damage. The amino-terminal region of Poly(ADP-ribose) polymerase consists of two PARP-type zinc fingers. This region acts as a DNA nick sensor.
Statistics
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PSSM-Id: 459887
Aligned: 182 rows
Threshold Bit Score: 55.4019
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1V9X_A         14 EYAKSSRSSCKTCKSVINKENFRLGKLVQSthf--------dgIMPMWNHASCILKKTKQIKSVDD-------VEGIESL 78   thale cress
ESN98431        7 DYAKLGTAGCKKCKVKLEKGALRLAKVTPNpftd------gegEMKQYFHPKCLFETFTKARSTTKvvdspndLQNYDSL 80  
Q21275         12 DYAKR-VAKCQKCKMQLEKGVLRMGKIMPNffvaakdpskpppDMKQYFHTNCLFEMLFKARPTTKvidetdeIEGFEDL 90   Caenorhabditi...
EEZ98905        9 EVARQGRALCKKCRQKCVQGDLRIAKLIPNplg--------sgKMKTWYHVSCIFETFLKQRQTTKriegpldIDGWESL 80  
XP_001943689   13 EKSKSNRAKCKKCKEVLNQGALRIAKVVANpfg--------dgKMMAWHHPQCLVTVFSKQRASTAkitcvddIGGWDGL 84  
XP_004925682   10 DRAKGGRAACKLCKGNCPSGELRMAKLVPSpyg-------dnqSMKSWYHVHCFTDVLLKQRPNTKrvesindIGNWDNI 82  
OWR49539       10 DRAKVGRANCKGCKAHCESGQLRIAKLVASpyg-------enqQMKSWHHVNCLMNVLLKQRPTTKridsiddIGNWDNI 82  
EEB12512       18 DRAKTGRAGCKKCKQKISQGELRMAKLAYNpfg--------tgTIKQWHHIQCIFDVFKKQRATTKkiehpdeIGGWDNL 89  
XP_002113418    8 EYDRSGRASCKGCKQKLEKKALRIAKVVENpfgd------tgeTMKQWHHPKCIFNSFIRARPATKiiqtvadIDGYDDL 81  
XP_001630058   11 EYAPQGRAKCKGCKEQIEKSSARIAKLAPNpfse------dggLMKQWYHVKCIFDSFSRARATTKkiedaedLDGFVDM 84  
1V9X_A         79 RWEDQQKIRKYV 90   thale cress
ESN98431       81 KAEDQNLINNLI 92  
Q21275         91 NAEDQDEIKKLV 102  Caenorhabditis elegans
EEZ98905       81 DPDDKVNILEKI 92  
XP_001943689   85 SMEHQNEI---L 93  
XP_004925682   83 SKEDQELILKKL 94  
OWR49539       83 SKEDQEFIIKEV 94  
EEB12512       90 NENDQQEIINYF 101 
XP_002113418   82 EDDDQESVSQMI 93  
XP_001630058   85 KQDDQNTIKQLI 96  
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