1YCJ,1TXF,2F34,2ZNS,2WKY,2F36,3C31,3FUZ


Conserved Protein Domain Family
PBP2_iGluR_Kainate_GluR5
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cd13722: PBP2_iGluR_Kainate_GluR5 
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GluR5 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily.
This group contains glutamate receptor domain GluR. These domains are found in the GluR proteins that have been shown to function as L-glutamate activated potassium channels, also known ionotropic glutamate receptors or iGluRs. In addition to two ligand binding core domains, iGluRs typically have a channel-like domain inserted in the middle of the GluR-like domain. Animal iGluRs mediate the ion flux in the synapses of the CNS and can be subdivided into several classes depending on the neurotransmitter specificity and ion conductance properties. Their plant homologs have been shown to function in light signal transduction and calcium homeostasis. The GluR proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
Links
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Statistics
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PSSM-Id: 270440
Aligned: 15 rows
Threshold Bit Score: 450.657
Created: 23-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide bindingdimer interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:2F34; Rattus norvegicus GluR5 binds Ubp310 (antagonist), contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                     
1YCJ_A      3 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFLYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 81  Norway rat
2F34_A      3 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFLYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 81  Norway rat
2ZNS_A      2 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFIYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 80  human
P39086    446 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFIYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 524 chimpanzee
NP_000821 446 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFIYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 524 human
AAG00455  445 NRTLIVTTILENPYVMYKksdkplygnDRFEGYCLDLLKELSNILGFSYEAKLVSdgkYGAQNdkGEWNGMVRELIDHV- 523 giant danio
CAG12769  202 NRTLIVTTILENPYVMYKksdkplygnDRFEGYCLDLLKELSNILGFSYEVKLVSdgkYGAQNdkGEWNGMVRELIDHVs 281 Tetraodon nigrovir...
Q38PU4    446 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFIYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 524 crab-eating macaque
2WKY_A      3 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFLYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 81  Norway rat
2F36_A      3 NRTLIVTTILEEPYVMYRksdkplygnDRFEGYCLDLLKELSNILGFLYDVKLVPdgkYGAQNdkGEWNGMVKELIDHR- 81  Norway rat

Feature 1                                     ###    #                                        
1YCJ_A     82 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGT----------------- 118 Norway rat
2F34_A     82 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGT----------------- 118 Norway rat
2ZNS_A     81 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGT----------------- 117 human
P39086    525 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdi 578 chimpanzee
NP_000821 525 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdi 578 human
AAG00455  524 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNgtnpgvfsflnplspdi 577 giant danio
CAG12769  282 tslgwncrrrfgrssesdlcpllcqvADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNgtnpgvfsflnplspdi 361 Tetraodon nigrovir...
Q38PU4    525 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNgtnpgvfsflnplspdi 578 crab-eating macaque
2WKY_A     82 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGT----------------- 118 Norway rat
2F36_A     82 --------------------------ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGT----------------- 118 Norway rat

Feature 1                                                                                     
1YCJ_A        --------------------------------------------------------------------------------     Norway rat
2F34_A        --------------------------------------------------------------------------------     Norway rat
2ZNS_A        --------------------------------------------------------------------------------     human
P39086    579 wmyvllaclgvscvlfviarftpyewynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwff 658 chimpanzee
NP_000821 579 wmyvllaclgvscvlfviarftpyewynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwff 658 human
AAG00455  578 wmyvllaclgvscvlfviarftpyewynlhpcnpdsdvvennftlinsvwfgvgalmqqgselmpkalstrivggiwwff 657 giant danio
CAG12769  362 wmyvllaclgvscvlfviarftpyewynphpcnpdsdvvennftlinsvwfgvgalmqqgselmpkalstrivggiwwff 441 Tetraodon nigrovir...
Q38PU4    579 wmyvllaclgvscvlfviarftpyewynphpcnpdsdvvennftllnsfwfgvgalmqqgselmpkalstrivggiwwff 658 crab-eating macaque
2WKY_A        --------------------------------------------------------------------------------     Norway rat
2F36_A        --------------------------------------------------------------------------------     Norway rat

Feature 1                                                                                     
1YCJ_A    119 -----------------------PIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqSALVKNSDE 175 Norway rat
2F34_A    119 -----------------------PIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqSALVKNSDE 175 Norway rat
2ZNS_A    118 -----------------------PIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqTALVRNSDE 174 human
P39086    659 tliiissytanlaafltvermesPIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqTALVRNSDE 738 chimpanzee
NP_000821 659 tliiissytanlaafltvermesPIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqTALVRNSDE 738 human
AAG00455  658 tliiissytanlaafltvermdsPIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRknTALVKNNRE 737 giant danio
CAG12769  442 tliiissytanlaafltvermdsPIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRknTALVKNNRE 521 Tetraodon nigrovir...
Q38PU4    659 tliiissytanlaafltvermesPIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqTALVRNSDE 738 crab-eating macaque
2WKY_A    119 -----------------------PIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqSALVKNSDE 175 Norway rat
2F36_A    119 -----------------------PIDSADDLakqtkIEYGAVRDGSTMTFFKkskiSTYEKMWAFMSSRqqSALVKNSDE 175 Norway rat

Feature 1                                                                                  
1YCJ_A    176 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 252 Norway rat
2F34_A    176 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 252 Norway rat
2ZNS_A    175 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 251 human
P39086    739 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 815 chimpanzee
NP_000821 739 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 815 human
AAG00455  738 GIQRVLTTdYALLMESTSIEYISQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWR 814 giant danio
CAG12769  522 GIQRVLTTdYALLMESTSIEYISQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWR 598 Tetraodon nigroviridis
Q38PU4    739 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 815 crab-eating macaque
2WKY_A    176 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 252 Norway rat
2F36_A    176 GIQRVLTTdYALLMESTSIEYVTQRnCNLTQIGglIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR 252 Norway rat

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